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  • Autotransfusion During Intralesional Tumor Resection: Effectiveness of Leukocyte Reduction Filtration in Removing Neoplastic Cells (CSDTR) Rochester, Minn.

    The aims of this study are to investigate the presence of tumor cells after filtration of autologous blood products by intraoperative cell saver, and to demonstrate the feasibility of intraoperative blood salvage during intralesional tumor resection.

    Intraoperative blood salvage is a relatively safe and cost-effective alternative to allogeneic blood transfusion during procedures with large volume blood loss. Salvaged blood products are washed and filtered before reinfusion into the patient. Given the theoretical risk of systemically re-infusing samples contaminated with tumor cells, many surgeons refrain from using intraoperative blood salvage. Aside from a few small studies, there is a paucity of data on the ability of leukocyte reduction filters to remove tumor cells from salvaged blood products. Additionally, no studies to date have investigated this during intralesional tumor resections.

     
  • Sarcoma Resection Guided by Intraoperative Indocyanine Green Dye Fluorescence Angiography Rochester, Minn.

    The purpose of this study is to evaluate the use of ICG as an intraoperative guide during bone and soft tissue sarcoma resection to determine if ICG fluorescence will be an accurate, real-time, intraoperative margin detector during resection of musculoskeletal sarcomas.

Closed for Enrollment

  • Evaluation and Clinical Impact of Serum and Blood Metal Ion Levels in Patients with an Endoprosthesis Rochester, Minn.

    The overall goal of project is to determine if patients with an endoprosthesis have elevated metal ion levels and if this leads to increased cardiac or neural toxicity based on echocardiograms an neural cognitive testing.
  • Outcomes after Sacroiliac Resection for Pelvic Malignancy Rochester, Minn.

    The purpose of this study is to gather clinical data to allow for comparisons in operative time, surgical technique, blood loss, level of resection, type of reconstruction, healing (based upon clinical report and imaging studies), transfusion requirements, complications, return to the operating room, and margins. There are other important data available that will also be recorded in order to draw comparisons to prior studies (Beadle, CORR 2005):  length of hospitalization, disposition at discharge, histology and grade of tumor, local recurrences, overall survival, duration of follow up, surgeon reported outcomes (MSTS 1987), chemotherapy regimen, radiation regimen, subsequent non-orthopedic oncologic surgeries.
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