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Validation of Potential Biomarkers for Pancreas Cancer in Human Saliva

Overview

Información sobre este estudio

The goal of this study is to determine if the biomarkers found to be upregulated in tissue samples are specific to PDAC and can be detected in saliva. Saliva will be collected form PDAC and control subjects for comparison. Additionally, to determine if the biomarkers are specific to PDAC or other KRAS driven cancers, saliva will be collected from patients with breast and lung cancer. The saliva collected from these subjects will be studied for the presence of specific protein biomarkers and used in experiments such as western blots and ELISAs.

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers with an extremely low overall 5-year survival rate. In previous experiments, human formalin fixed paraffin embedded (FFPE) PDAC tissue samples were obtained for laser microdissection of precancerous pancreatic lesions. RNA was isolated from the tissue and sequenced. The RNA-seq data suggested that there were many potential biomarkers for PDAC that could positively impact the clinical setting and early-detection of the disease if validated in patient samples.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria:

  • Men and women between the ages of 20-90 years old. 
  • Young adults are less likely to have pancreas associated illness. We want to sample these individuals so that we can determine what a healthy expression profile would look like. We also want to obtain samples from older individuals that do not have pancreas associated illnesses so that we can use them as proper controls against samples from older patients with pancreatic cancer. This range encompasses a large portion of the population of potential donors on campus. 
  • PDAC, lung and breast cancer patients.
  • Volunteers to serve as controls with no previous history of jaundice, disease of the pancreas (pancreatitis, pancreatic cyst, and pancreatic cancer), other cancers in the past 5 years or Sjögren’s syndrome or has undergone radiation to the head or neck area. Appropriate volunteers include patient spouses, employees of Mayo Clinic, and relatives of employees of Mayo Clinic.

Exclusion Criteria:

  • We will not be seeking out one minority group over the other, nor will we be refusing the inclusion of one minority group over the other.

Eligibility last updated 2/7/232. Questions regarding updates should be directed to the study team contact.

 

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus Contacto

Jacksonville, Fla.

Investigador principal de Mayo Clinic

Peter Storz, Ph.D.

Cerrado; inscripción por invitación

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El estudio no está abierto para todos los que cumplen con los criterios de elegibilidad, sino solamente para las personas que el equipo del estudio ha invitado a participar.

Contact information:

Jillian Eisenhauer

(904) 953-6382

Eisenhauer.Jillian@mayo.edu

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20544832

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