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The Relationship Between Endoscopic Inflammation and Health-related Quality of Life in Patients with Ulcerative Colitis

Overview

Información sobre este estudio

Primary Aim

            We aim to evaluate: 1) the correlation between patient-reported rectal bleeding and stool frequency and health-related quality of life focused on fatigue, depression and anxiety, and work productivity; and 2) the correlation between the severity of endoscopic inflammation and health-related quality of life focused on fatigue, depression and anxiety, and work productivity.

Secondary Aims

We also aim to evaluate the correlation between the combination of clinical/PRO and the severity of endoscopic inflammation and health-related quality of life focused on fatigue, depression and anxiety, and work productivity.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria:

Consecutive patients with ulcerative colitis who attend the IBD Clinic in the Division of Gastroenterology and Hepatology at Mayo Clinic in Rochester and who have been scheduled for a clinical sigmoidoscopy or colonoscopy for assessment of disease activity or colorectal cancer surveillance.

Exclusion Criteria:

  • active cancer diagnosis (not fully treated),
  • the presence of other chronic immune-mediated diseases such as spondyloarthropathy,
  • primary sclerosing cholangitis,
  • previous partial colectomy,
  • perianal disease including fissures and fistulas,
  • previous pelvic radiation,
  • rectal prolapse,
  • anal sphincter incompetence,
  • celiac disease,
  • microscopic colitis,
  • chronic laxative use, and
  • pregnancy.  
  • Patients with proctocolectomy and ileal pouch-anal anastomosis

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus

Rochester, Minn.

Investigador principal de Mayo Clinic

Edward Loftus, M.D.

Cerrado para la inscripción

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20314178

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