The Relationship Between Endoscopic Inflammation and Health-related Quality of Life in Patients with Ulcerative Colitis

Overview

About this study

Primary Aim

We aim to evaluate: 1) the correlation between patient-reported rectal bleeding and stool frequency and health-related quality of life focused on fatigue, depression and anxiety, and work productivity; and 2) the correlation between the severity of endoscopic inflammation and health-related quality of life focused on fatigue, depression and anxiety, and work productivity.

Secondary Aims

We also aim to evaluate the correlation between the combination of clinical/PRO and the severity of endoscopic inflammation and health-related quality of life focused on fatigue, depression and anxiety, and work productivity.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Consecutive patients with ulcerative colitis who attend the IBD Clinic in the Division of Gastroenterology and Hepatology at Mayo Clinic in Rochester and who have been scheduled for a clinical sigmoidoscopy or colonoscopy for assessment of disease activity or colorectal cancer surveillance.

Exclusion Criteria:

active cancer diagnosis (not fully treated),
the presence of other chronic immune-mediated diseases such as spondyloarthropathy,
primary sclerosing cholangitis,
previous partial colectomy,
perianal disease including fissures and fistulas,
previous pelvic radiation,
rectal prolapse,
anal sphincter incompetence,
celiac disease,
microscopic colitis,
chronic laxative use, and
pregnancy.
Patients with proctocolectomy and ileal pouch-anal anastomosis

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Edward Loftus, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Edward Loftus, M.D.

Closed for enrollment

More information

Publications

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