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Sleep-Related Determinants of Stroke

Overview

Información sobre este estudio

Stroke is the second leading cause of death worldwide. Traditional stroke risk factors explain about half of the risk for stroke. The remaining half may be partially explained by sleep duration and disturbances, which are prospectively related to incident stroke across multiple populations. Although these relationships have been identified, at present, essentially nothing is known regarding the modifiable, sleep-inhibiting behaviors that determine sleep duration and disruption; these are probable targets of stroke prevention. The study proposed here is intended to fill this void by determining the relation between sleep-inhibiting behaviors, self-reported sleep duration and disruption, and stroke amongst acute stroke inpatients.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria:

  • Adults (≥30yrs) who acutely experienced their first ischemic stroke and were hospitalized at the Mayo Clinic.
  • Controls will be 40 age (±5yrs) sex, and ethnicity-matched relatives that are full/half siblings, or first cousins of the cases
  • Able to understand and speak English
  • Provide informed consent

Exclusion Criteria: 

  • Intrinsic sleep disorder diagnosis
  • Screen positive for sleep apnea (STOP-BANG score of greater than three)
  • Nocturnal movement-related disorder
  • Decreased level of consciousness (NIH Stroke Scale (NIHSS) item 1A)
  • Inability to respond correctly to questions or commands (NIHSS 1B, 1C)
  • Inability to complete 3-step commands
  • Cognitive dysfunction
  • Aphasia
  • Medical needs that would place the participant at risk or prevent the patient from receiving scheduled medical care
  • Time since the event is greater than one week
  • Controls will be excluded if they:
    • Report a history of stroke, or stroke symptoms within the past six months  
    • They cannot participate within 30 days of the cases’ stroke event

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus

Scottsdale/Phoenix, Ariz.

Investigador principal de Mayo Clinic

James Parish, M.D.

Cerrado para la inscripción

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20306911

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