Sleep-Related Determinants of Stroke

Overview

About this study

Stroke is the second leading cause of death worldwide. Traditional stroke risk factors explain about half of the risk for stroke. The remaining half may be partially explained by sleep duration and disturbances, which are prospectively related to incident stroke across multiple populations. Although these relationships have been identified, at present, essentially nothing is known regarding the modifiable, sleep-inhibiting behaviors that determine sleep duration and disruption; these are probable targets of stroke prevention. The study proposed here is intended to fill this void by determining the relation between sleep-inhibiting behaviors, self-reported sleep duration and disruption, and stroke amongst acute stroke inpatients.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Adults (≥30yrs) who acutely experienced their first ischemic stroke and were hospitalized at the Mayo Clinic.
Controls will be 40 age (±5yrs) sex, and ethnicity-matched relatives that are full/half siblings, or first cousins of the cases
Able to understand and speak English
Provide informed consent

Exclusion Criteria:

Intrinsic sleep disorder diagnosis
Screen positive for sleep apnea (STOP-BANG score of greater than three)
Nocturnal movement-related disorder
Decreased level of consciousness (NIH Stroke Scale (NIHSS) item 1A)
Inability to respond correctly to questions or commands (NIHSS 1B, 1C)
Inability to complete 3-step commands
Cognitive dysfunction
Aphasia
Medical needs that would place the participant at risk or prevent the patient from receiving scheduled medical care
Time since the event is greater than one week
Controls will be excluded if they:
- Report a history of stroke, or stroke symptoms within the past six months
- They cannot participate within 30 days of the cases’ stroke event

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Scottsdale/Phoenix, Ariz. Mayo Clinic principal investigator James Parish, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

James Parish, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Clinical Trials