Ensayos clínicos

Inclusion Criteria:

• Histological diagnosis of thoracic neoplasia and cardiac exposure from curative intent proton beam or photon radiotherapy:
  • Esophageal cancer (stages I, II, III);
  • Lung cancer (stages I, II and III and recurrent non-small cells lung cancer and small cells lung cancer and thymoma);
  • Breast cancer (stage I, stage II, stage III or recurrent undergoing regional nodal irradiation);
  • Hodgkin’s lymphoma (stages I, II, III, IV) and non-Hodgkin’s lymphoma (stages I, II, III).
• Anticipated mean heart dose ≥ 1 Gy with a photon radiotherapy plan.

Absolute Exclusion Criteria: 

• Inadequate image quality.
• Irregular R-R Interval.
• Age < 18 years.

Relative Exclusion Criteria:

• Previous cardiovascular diseases (myocardial infarction, congestive heart failure, and cardiomyopathy): patients with prior thoracic radiotherapy may be enrolled and undergo a baseline echocardiogram. Patients will be excluded if the baseline echocardiogram is abnormal.
• Moderate or severe valvular stenosis or regurgitation.
• Uncontrolled hypertension.
• Prior thoracic radiotherapy: patients with prior thoracic radiotherapy may be enrolled and undergo a baseline echocardiogram. Patients will be excluded if the baseline echocardiogram is abnormal.