Cardiac Function in Patients Undergoing Proton Beam or Photon Radiotherapy

Overview

About this study

The purpose of this study is to determine whether conventional or new (2D- speckle tracking echocardiography) parameters of left and right ventricular function are impaired during and at the end of proton beam or photon radiotherapy.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Histological diagnosis of thoracic neoplasia and cardiac exposure from curative intent proton beam or photon radiotherapy:
- Esophageal cancer (stages I, II, III);
- Lung cancer (stages I, II and III and recurrent non-small cells lung cancer and small cells lung cancer and thymoma);
- Breast cancer (stage I, stage II, stage III or recurrent undergoing regional nodal irradiation);
- Hodgkin’s lymphoma (stages I, II, III, IV) and non-Hodgkin’s lymphoma (stages I, II, III).
Anticipated mean heart dose ≥ 1 Gy with a photon radiotherapy plan.

Absolute Exclusion Criteria:

Inadequate image quality.
Irregular R-R Interval.
Age < 18 years.

Relative Exclusion Criteria:

Previous cardiovascular diseases (myocardial infarction, congestive heart failure, and cardiomyopathy): patients with prior thoracic radiotherapy may be enrolled and undergo a baseline echocardiogram. Patients will be excluded if the baseline echocardiogram is abnormal.
Moderate or severe valvular stenosis or regurgitation.
Uncontrolled hypertension.
Prior thoracic radiotherapy: patients with prior thoracic radiotherapy may be enrolled and undergo a baseline echocardiogram. Patients will be excluded if the baseline echocardiogram is abnormal.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Hector Villarraga, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Hector Villarraga, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Clinical Trials