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A Study to See if Collecting Cells with a Brush Will Have a Better Rate of Finding Cancer Cells in the Esophagus

Overview

Información sobre este estudio

The purpose of this study is to see if collecting cells from the lining of the esophagus with a brush in addition to the biopsies taken for standard medical care will have a better rate of finding cancer cells related to having Barrett's esophagus.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria

  • Age: ≥ 18 years
  • Should have a history of Barrett’s esophagus (with or without dysplasia of either indefinite, low grade or high-grade)
  • Willingness to undergo both WATS and forceps biopsies while undergoing conventional EGD with sedation
  • Ability to provide written, informed consent (approved by IRB) and understand the responsibilities of trial participation
  • Only patients who undergo both forceps biopsies and WATS of the esophagus will be included in this study

 

Exclusion Criteria

  • Coagulopathy with INR > 2.0, thrombocytopenia with platelet counts < 50,000
  • Is pregnant or planning a pregnancy during the study period
  • History of esophageal, gastric surgery
  • Has undergone ablative therapies
  • Has a known history of unresolved drug or alcohol dependency that would limit ability to comprehend or follow instructions related to informed consent, post-treatment instructions, or follow-up guidelines
  • Patients with inadequate specimens will not undergo a repeat brush biopsy test and will be excluded from the study
  • BE length < 1 cm or > 10 cm
  • Any polypoid/ulcerated lesion > 10mm concerning for invasive cancer on endoscopy
  • Visible lesions that are either submucosal or covered with a clinically intact epithelium

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20164336

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