A Study to See if Collecting Cells with a Brush Will Have a Better Rate of Finding Cancer Cells in the Esophagus

Overview

About this study

The purpose of this study is to see if collecting cells from the lining of the esophagus with a brush in addition to the biopsies taken for standard medical care will have a better rate of finding cancer cells related to having Barrett's esophagus.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

Age: ≥ 18 years
Should have a history of Barrett’s esophagus (with or without dysplasia of either indefinite, low grade or high-grade)
Willingness to undergo both WATS and forceps biopsies while undergoing conventional EGD with sedation
Ability to provide written, informed consent (approved by IRB) and understand the responsibilities of trial participation
Only patients who undergo both forceps biopsies and WATS of the esophagus will be included in this study

Exclusion Criteria

Coagulopathy with INR > 2.0, thrombocytopenia with platelet counts < 50,000
Is pregnant or planning a pregnancy during the study period
History of esophageal, gastric surgery
Has undergone ablative therapies
Has a known history of unresolved drug or alcohol dependency that would limit ability to comprehend or follow instructions related to informed consent, post-treatment instructions, or follow-up guidelines
Patients with inadequate specimens will not undergo a repeat brush biopsy test and will be excluded from the study
BE length < 1 cm or > 10 cm
Any polypoid/ulcerated lesion > 10mm concerning for invasive cancer on endoscopy
Visible lesions that are either submucosal or covered with a clinically intact epithelium

More information

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