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Effects of Aerobic and Resistance Training on Accumulation of Old, Modified Proteins in Young and Older Adults

Overview

Información sobre este estudio

Muscle proteins accumulate damage during aging and leads to the loss of muscle mass and function in older people. Exercise can increase the making of new proteins and removal of older proteins, but it is not known if the effect changes with aging or type of exercise. The investigators will determine the ability for endurance, resistance, or a combination of exercise training to remove older-damaged proteins and make newer-functional muscle proteins in groups of younger and older people. The investigators will particularly study protein that are involved with energy production (mitochondrial proteins) and force production (contractile proteins).

Hypothesis 1: Older people will have greater accumulation of damaged proteins than younger people.

Hypothesis 2: Aerobic exercise will decrease the accumulation of damaged forms of contractile and mitochondrial proteins in younger and older people.

Hypothesis 3: Resistance exercise will decrease the accumulation of damaged forms of contractile proteins in younger and older people.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria:

  • Healthy.
  • 18 to 30 years or 65 to 80 years old.
  • Male and female.

Exclusion Criteria:

  • Regular exercise program.
  • Smoking.
  • Metabolic disease (diabetes, cardiovascular disease, cancer, thyroid disorders).
  • Pregnancy.
  • Inability to exercise.
  • Overweight or obesity.
  • Drugs known to impair metabolic function (statin, beta-blocker, anti- ).
  • Allergies to lidocaine.
  • BMI > 32 kg/m^2.

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus Contacto

Rochester, Minn.

Investigador principal de Mayo Clinic

K Nair, M.D., Ph.D.

Cerrado para la inscripción

Contact information:

Frederick de Ruiter

(507) 255-8932

DeRuiter.Frederick@mayo.edu

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20129486

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