Effects of Aerobic and Resistance Training on Accumulation of Old, Modified Proteins in Young and Older Adults

Overview

About this study

Muscle proteins accumulate damage during aging and leads to the loss of muscle mass and function in older people. Exercise can increase the making of new proteins and removal of older proteins, but it is not known if the effect changes with aging or type of exercise. The investigators will determine the ability for endurance, resistance, or a combination of exercise training to remove older-damaged proteins and make newer-functional muscle proteins in groups of younger and older people. The investigators will particularly study protein that are involved with energy production (mitochondrial proteins) and force production (contractile proteins).

Hypothesis 1: Older people will have greater accumulation of damaged proteins than younger people.

Hypothesis 2: Aerobic exercise will decrease the accumulation of damaged forms of contractile and mitochondrial proteins in younger and older people.

Hypothesis 3: Resistance exercise will decrease the accumulation of damaged forms of contractile proteins in younger and older people.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Healthy.
18 to 30 years or 65 to 80 years old.
Male and female.

Exclusion Criteria:

Regular exercise program.
Smoking.
Metabolic disease (diabetes, cardiovascular disease, cancer, thyroid disorders).
Pregnancy.
Inability to exercise.
Overweight or obesity.
Drugs known to impair metabolic function (statin, beta-blocker, anti- ).
Allergies to lidocaine.
BMI > 32 kg/m^2.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator K Nair, M.D., Ph.D.	Closed for enrollment	Contact information: Frederick de Ruiter (507) 255-8932 DeRuiter.Frederick@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

K Nair, M.D., Ph.D.

Closed for enrollment

Contact information:

Frederick de Ruiter

(507) 255-8932

DeRuiter.Frederick@mayo.edu

More information

Publications

Publications are currently not available

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