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Feasibility Trial Using Imaging and Biochemical Technologies to Measure Knee Cartilage Composition in Acute ACL Injury

Overview

Información sobre este estudio

This study will evaluate the bio-mechanical and biochemical abnormalities in acute ACL-injured knees over time. Data will be collected through advanced quantitative MR imaging, functional testing, and bio-specimen collection. Researchers will collect this data from the time of baseline visit, which is within 28 days of injury, through the temporal sequence of post-operative or post-injury recovery and return to activity.

The hypotheses for this study are (1) that T1ρ and T2 will be significantly elevated in the lateral side of ACL-injured knees immediately after injury (indicating damage caused by initial injury), and will not fully recover at 6-month, 1-year follow ups; (2) that T1ρ and T2 will be significantly elevated in the medial side of ACL-injured knees at 1-year follow-up; and (3) that differences in the bio-marker expression patterns can be correlated with the initial MRI findings, which would provide information regarding the full spectrum of intra-articular pathology and the subsequent clinical outcomes.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria:

  • Skeletally mature subjects with age 13 - 55 years
  • Sustain an acute full ACL rupture in one knee < 28 day
  • May or may not undergo ACL reconstruction
  • Low grade injury to the collateral ligaments not resulting in instability and not requiring reconstruction will be included

Exclusion Criteria:

  • Radiographic evidence of early osteoarthritis, defined as Grade 1 joint space narrowing or Grade 1 osteophyte formation
  • Injuries to other ligaments requiring surgical intervention
  • Have cartilage resurfacing procedures performed at the time of injury
  • Inability to undergo the standard pre- and post-injury/operative rehabilitation
  • Varus or valgus instability requiring ligament repair or reconstruction (from clinical exam at time of injury)
  • History of osteoarthritis and inflammatory arthritis
  • Women who are pregnant are excluded
  • Previous injury and/or surgery on either knee

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus Contacto

Rochester, Minn.

Investigador principal de Mayo Clinic

Aaron Krych, M.D.

Cerrado para la inscripción

Contact information:

Jennifer Krogman

(507) 538-3562

Krogman.Jennifer@mayo.edu

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20124668

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