Feasibility Trial Using Imaging and Biochemical Technologies to Measure Knee Cartilage Composition in Acute ACL Injury

Overview

About this study

This study will evaluate the bio-mechanical and biochemical abnormalities in acute ACL-injured knees over time. Data will be collected through advanced quantitative MR imaging, functional testing, and bio-specimen collection. Researchers will collect this data from the time of baseline visit, which is within 28 days of injury, through the temporal sequence of post-operative or post-injury recovery and return to activity.

The hypotheses for this study are (1) that T1ρ and T2 will be significantly elevated in the lateral side of ACL-injured knees immediately after injury (indicating damage caused by initial injury), and will not fully recover at 6-month, 1-year follow ups; (2) that T1ρ and T2 will be significantly elevated in the medial side of ACL-injured knees at 1-year follow-up; and (3) that differences in the bio-marker expression patterns can be correlated with the initial MRI findings, which would provide information regarding the full spectrum of intra-articular pathology and the subsequent clinical outcomes.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Skeletally mature subjects with age 13 - 55 years
Sustain an acute full ACL rupture in one knee < 28 day
May or may not undergo ACL reconstruction
Low grade injury to the collateral ligaments not resulting in instability and not requiring reconstruction will be included

Exclusion Criteria:

Radiographic evidence of early osteoarthritis, defined as Grade 1 joint space narrowing or Grade 1 osteophyte formation
Injuries to other ligaments requiring surgical intervention
Have cartilage resurfacing procedures performed at the time of injury
Inability to undergo the standard pre- and post-injury/operative rehabilitation
Varus or valgus instability requiring ligament repair or reconstruction (from clinical exam at time of injury)
History of osteoarthritis and inflammatory arthritis
Women who are pregnant are excluded
Previous injury and/or surgery on either knee

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Aaron Krych, M.D.	Closed for enrollment	Contact information: Jennifer Krogman (507) 538-3562 Krogman.Jennifer@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Aaron Krych, M.D.

Closed for enrollment

Contact information:

Jennifer Krogman

(507) 538-3562

Krogman.Jennifer@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials