Physiologic Effects of Sleep Restriction

Overview

Información sobre este estudio

Evidence suggests a relationship between sleep deprivation and cardiovascular disease. The investigators wish to determine whether 9 nights of modest sleep restriction results in activation of cardiovascular disease mechanisms, thus potentially increasing the risk of cardiovascular disease. The investigators hypothesize that sleep restriction will result in elevated blood pressure, inflammation, and neurocognitive deficits.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria:

  • Age 18-40 years
  • No chronic medical conditions other than seasonal or environmental allergies
  • On no prescription medications other than second generation antihistamines (Cetirizine, Fexofenadine, Desloratadine, Loratadine, etc), oral contraceptive pills, or intrauterine devices.
  • BMI 18.5-35 kg/m2
  • Both normotensive and prehypertensive people are eligible and will be studied
  • Not a current smoker or tobacco user
  • Not pregnant or breast feeding and not intending to become pregnant or breast feed

Exclusion Criteria:

  • The investigators will exclude subjects who have any medical or psychiatric disorders
  • History of anxiety or depression, and those taking any medications other than non-sedating antihistamines or oral contraceptives.
  • Those found to have depression on a depression screening tool (BDI-II) will be excluded. Current smokers will be excluded.
  • All female subjects will undergoing a screening pregnancy test and excluded if positive.
  • Subjects found to have significant sleep disorders will be excluded.

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus Contacto

Rochester, Minn.

Investigador principal de Mayo Clinic

Virend Somers, M.D., Ph.D.

Cerrado para la inscripción

Contact information:

Olivia Louks

(507) 422-0767

Louks.Olivia@mayo.edu

More information

Publicaciones

Publications are currently not available
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CLS-20112232

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