Physiologic Effects of Sleep Restriction

Overview

About this study

Evidence suggests a relationship between sleep deprivation and cardiovascular disease. The investigators wish to determine whether 9 nights of modest sleep restriction results in activation of cardiovascular disease mechanisms, thus potentially increasing the risk of cardiovascular disease. The investigators hypothesize that sleep restriction will result in elevated blood pressure, inflammation, and neurocognitive deficits.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Age 18-40 years
No chronic medical conditions other than seasonal or environmental allergies
On no prescription medications other than second generation antihistamines (Cetirizine, Fexofenadine, Desloratadine, Loratadine, etc), oral contraceptive pills, or intrauterine devices.
BMI 18.5-35 kg/m2
Both normotensive and prehypertensive people are eligible and will be studied
Not a current smoker or tobacco user
Not pregnant or breast feeding and not intending to become pregnant or breast feed

Exclusion Criteria:

The investigators will exclude subjects who have any medical or psychiatric disorders
History of anxiety or depression, and those taking any medications other than non-sedating antihistamines or oral contraceptives.
Those found to have depression on a depression screening tool (BDI-II) will be excluded. Current smokers will be excluded.
All female subjects will undergoing a screening pregnancy test and excluded if positive.
Subjects found to have significant sleep disorders will be excluded.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Virend Somers, M.D., Ph.D.	Closed for enrollment	Contact information: Olivia Louks (507) 422-0767 Louks.Olivia@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Virend Somers, M.D., Ph.D.

Closed for enrollment

Contact information:

Olivia Louks

(507) 422-0767

Louks.Olivia@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials