SUMMARY
The research of Sundeep Khosla, M.D., focuses on the mechanisms of age-related bone loss. Dr. Khosla's research group in his Osteoporosis and Bone Biology Laboratory, examines how fundamental aging mechanisms in bone, particularly cellular senescence, lead to increased skeletal fragility. He studies how the aging skeleton interacts with other tissues, including muscle, fat and brain tissues. Dr. Khosla's laboratory has developed a number of genetic models for the clearance of senescent cells globally and in a tissue-specific manner.
His group also has used single-cell proteomic and transcriptomic tools to identify senescent cells in vivo in the bone microenvironment and how these cells interact with immune cells. Dr. Khosla studies the role of senescent cells in tissue repair, specifically fracture healing.
In clinical studies, Dr. Khosla performs trials using new approaches to prevent age-related bone loss after menopause.
Focus areas
- Mechanisms of age-related bone loss.
- Cellular senescence in bone and other tissues.
- Role of cellular senescence in tissue repair.
- Interactions of aging bone and immune cells.
Significance to patient care
Dr. Khosla's work has the potential to significantly impact how people with osteoporosis are diagnosed and treated. He defines the pathways that lead to bone loss with aging. These pathways may identify new molecular targets for medicines to reverse osteoporosis. Additionally, his studies on fracture healing may lead to new approaches to prevent fracture nonunions.
Professional highlights
- Cartwright Lecture, Irving Medical Center, Columbia University, 2023.
- Director, Center for Clinical and Translational Science, Mayo Clinic, 2013-2020.
- Council member, National Institute of Arthritis and Musculoskeletal and Skin Diseases, 2014-2018.
- Frontiers in Science Award, American Association of Clinical Endocrinologists, 2018.
- Jacobaeus International Prize for outstanding research in physiology and endocrinology, Novo Nordisk Foundation, 2018.
- William F. Neuman Award for Outstanding Scientific Contributions, American Society for Bone and Mineral Research, 2012.
- President, American Society for Bone and Mineral Research, 2010-2011.
- Member, National Advisory Council on Aging, 2007-2010.
- Outstanding Clinical Investigator Award, Endocrine Society, 2010.
- Dr. Francis Chucker and Nathan Landow Research Professor and Mayo Foundation Distinguished Investigator, Mayo Clinic, 2009.
- Elected, Association of American Physicians, 2007.
- Frederic C. Bartter Award for clinical investigation in bone diseases, American Society for Bone and Mineral Research, 2006.
- Elected, American Society for Clinical Investigation, 2003.