SUMMARY
The research of Suman Bose, Ph.D., focuses on the interface of biomaterial science, cellular engineering and drug delivery with the aim of creating next-generation cell-based therapies.
Dr. Bose's research team combines multiscale manufacturing techniques, material chemistry, and molecular and cellular engineering principles to build implants. These implants can deliver precise doses of therapeutics in real time.
Dr. Bose's research focuses on performing fundamental studies to gain mechanistic insights into the cross-talk between the host immune system and implanted devices. These insights are used to design durable implants that resist host rejection and integrate better within host tissue.
His research develops long-term therapies for chronic diseases such as type1diabetes mellitus, liver failure, blood disorders and immune dysfunction.
Focus areas
Engineering therapeutic cells and delivery technologies for treating chronic diseases. Transplanted therapeutic cells have shown great promise in treating chronic conditions such as type 1 diabetes mellitus and liver failure. However, poor engraftment and rapid rejection by the host immune system have prevented clinical success.
Dr. Bose uses innovative genomic and synthetic biology techniques to engineer programable cells capable of delivering precise doses of therapeutics that are suitable for clinical translation. His research also focuses on building implants to safely deliver and retain these cells at the target organs.
Understanding how material design affects tissue interactions. Foreign body response to implants is the primary cause of failure for several biomedical devices. This failure can lead to health complications and expensive follow-up surgeries.
Dr. Bose develops platforms to understand how the fundamental physiochemical aspects of material design, such as composition, geometry and size, affect immune cell interactions during an immune response. This research helps create next-generation biomaterials and implants that are designed to resist fibrosis.
Significance to patient care
Cell therapy is a promising and rapidly advancing field of medicine with the potential to create transformative cures across disease areas. It involves replacing diseased and damaged tissue within the body with healthy cells.
These therapeutic cells can secrete factors to restore damaged organs, halt or reverse disease progression, and cure life-threatening conditions. Despite this promise, significant scientific and clinical challenges must be addressed for cell therapy to be clinically successful.
Dr. Bose's research focuses on engineering strategies to overcome challenges such as early graft failure and low retention of cells at the targeted site. He also develops new cell-based platforms that are effective for long periods in the body. This research creates new treatments for chronic diseases, immune dysfunction and tissue regeneration.
Professional highlights
- Massachusetts Institute of Technology (MIT).
- Peter Karches Mentorship Prize, 2021.
- Koch Institute Image Award, 2019.
- Stanley and Bonnie Klein Research Travel Fellowship, 2017.
- Mission Possible Prize, Koch Institute, 2016.
- Pappalardo Graduate Fellowship, 2007.
- Pathway to Independence Award, National Institute of Health, 2018.
- Future of Science Award, Keystone Symposia, 2017.
- Top 40 Under 40 Healthcare Innovators, MedTech, 2016.
- Postdoctoral fellowship, Juvenile Diabetes Research Foundation, 2015.
- Outstanding Paper Award, for "Nano Engineering in Medicine and Biology," The American Society of Mechanical Engineers, 2013.
- Institute Silver Medal, Indian Institute of Technology Kharagpur, India, 2007.