Jacob L. Sellon, M.D.

The purpose of this study is to examine the effect of examine the effect of a single autologous, intra-articular injection of MFat versus corticosteroid injection for the treatment of pain and function associated with K/L grade 2/3 knee Osteoarthritis. Participants will receive an injection of MFat or a corticosteroid.

The purpose of this study is to examine the effect of a single autologous, intra-articular injection of MFat versus saline injection for the treatment of pain and function associated with K/L grade 2/3 knee osteoarthritis.

The purpose of this study is to examine the effect of a single autologous, intra-articular injection of MFat versus saline injection for the treatment of pain and function associated with K/L grade 2/3 knee osteoarthritis.

The purpose of this study is to evaluate the cellular composition of PRP produced by the Arthrex Angel System.

The purpose of this study is to determine patient and manufacturing factors that influence orthobiologic agent (OBA) product components and determine how they may influence patient outcomes.

Corticosteroid injections are commonly used for the symptomatic treatment of knee osteoarthritis. Common practice is to inject the joint with a combination of corticosteroid and local anesthetic, with the rationale of providing longer duration pain relief with the corticosteroid and immediate, though short duration relief with the anesthetic. However, multiple in vitro and animal studies have shown that local anesthetic may be harmful to chondrocytes. Despite this data, use of intra-articular anesthetic remains widespread. Many clinicians believe incorporating the anesthetic is important because it can provide immediate pain relief and facilitate patient confidence in the treatment program. However, there is no published data to validate this reasoning. Therefore, the anesthetic has unknown clinical benefit and may have adverse effects on articular cartilage. In light of this, the investigators question the routine use of anesthetics in joint injections. The purpose of this study is to compare the effects of knee joint injections using: 1) corticosteroid with local anesthetic versus 2) corticosteroid with normal saline.

The purpose of this study is to test the feasibility of a Digital Home-Exercise Therapy Application (DETP) by conducting a randomized, controlled, non-inferiority study to compare the DETP to conventional physical therapy (PT).

Local anesthesia is commonly used to reduce pain during joint injections, particularly for deep joints like the hip. Lidocaine is the most commonly used local anesthetic in most medical practices. It is well known that lidocaine infiltration itself is painful. Many strategies have been studied to minimize pain associated with lidocaine administration, including buffering, warming, and slowing infiltration rate. Bacteriostatic saline (BS) is an alternative local anesthetic that has been shown to be less painful when injected into subcutaneous tissues compared with lidocaine. However, BS use has not been widely implemented for local anesthesia, and it has not been studied in the context of joint injections. The purpose of this study is to compare infiltration pain and anesthetic efficacy between lidocaine and BS for ultrasound (US) guided intraarticular hip injections.

The purpose of this study is to determine the safety and practical treatment use of STEM cells collected from a patient's own fat tissue, expanded in laboratory culture, and injected to treat symptoms of mild to severe knee osteoarthritis.

The purpose of this study is to determine the safety of Ultrasound-guided Tenotomy (USGT) by describing the rate and types of USGT-related complications at the Achilles, and to demonstrate the feasibility of an RCT (randomized control trial) at each site by measuring the patient volume per year treated with USGT for Achilles Tendinopathy (AT), and capture rate utilizing a standardized ultrasound imaging protocol for AT.

The research is about the post-procedure outcomes and is not about the ultrasound device or the ultrasound-guided tenotomy procedure.

The purpose of this study is to determine and describe the expected outcomes (degree of pain relief, duration of pain relief, return to sport or desired activity, and secondary treatment interventions sought) for individuals who undergo ultrasound guided Achilles and patellar tendon scraping for tendinopathy.

There have been a wide variety of techniques suggested for performing stress sonography of the elbow medial ulnar collateral ligament (mUCL) to evaluate for underlying ulnohumeral joint (UHJ) instability. This is clinically relevant when using ultrasound to diagnose mUCL injuries by measuring ulnohumeral joint widening under stress. To assist the ultrasound operator, prior measurement techniques have stabilized, and stress loaded the elbow with a second operator or specialized instrumentation (Telos Device), as well as a two-operator technique. Reliability of these techniques has not been described. This study will attempt to validate a novel single operator technique that does not require additional equipment or a second person to assist with stressing the joint. It will also evaluate the reliability of the three described techniques. Healthy volunteers will be recruited to participate in this study. Operators JS and BB will complete stress sonography measurements of the ulnohumeral joint width using a single operator method, a two-operator method, and the Telos Medical Stress test device and compare the results for validation purposes. Intrarater and interrater reliability of these techniques will be also be assessed.