International Multicenter Registry of Cancer of the Pancreas Screening

Overview

About this study

To determine whether a surveillance program consisting of in a cohort of high-risk individuals results in an excess number of detected and surgically resected high-grade premalignant lesions and early stage pancreatic cancers compared to the natural disease development and manifestation.
To determine whether above mentioned strategy results in an improved survival
compared to high-risk individuals not under surveillance and compared to the survival
statistics of sporadic pancreatic cancer.
To determine patient and lesion characteristics by which precursor lesions can be stratified according their risk of malignant transformation.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Two or more affected blood relatives with PC, with at least one affected FDR
Peutz-Jeghers syndrome (STK11 mutation or clinical diagnosis), regardless of family history
p16 mutation carrier with ≥ 1 PC affected FDR
BRCA2 mutation carrier with ≥ 1 PC affected FDR or two or more affected blood relatives
PALB2 mutation carrier with ≥ 1 PC affected FDR
Lynch syndrome with ≥ 1 PC affected FDR
50 years of age or 10 years younger than the youngest PC case in the family

Exclusion Criteria:

Personal history of pancreatic cancer
Younger than 18 years of age
Older than 75 years of age
Unable to provide informed consent either due to mental retardation or a language barrier
Upper gastrointestinal tract obstruction or stricture that does not allow passage of an echoendoscope
Severe medical illness; (ASA score ≥ 3)

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Jacksonville, Fla. Mayo Clinic principal investigator Michael Wallace, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Jacksonville, Fla.

Mayo Clinic principal investigator

Michael Wallace, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

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