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A Study to Assess a New Personalized Tool for Colorectal Cancer Peritoneal Disease Treatment

Overview

About this study

The objectives of this study are to genomically characterize patient-derived organoids (PDOs) and primary tissues from colorectal peritoneal cancer (CRC) disease, to evaluate the use of PDOs as a new personalized therapy selection tool for intraperitoneal therapy in CRC peritoneal disease, and to evaluate the use of PDOs as a new personalized therapy selection tool for systemic therapy in CRC peritoneal disease.

 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age ≥ 18 years old.
  • Metastatic CRC patients with synchronous or metachronous peritoneal metastasis.
  • Patients who plan to undergo either diagnostic laparoscopy with tissue biopsy of the peritoneal metastases or cytoreductive surgery of the peritoneal metastases as part of routine clinical care.
  • Patients willing to consent for biopsy.

Exclusion Criteria: 

  • Patients who will not have tissue biopsy from diagnostic laparoscopy or tumor resection from cytoreductive surgery as part of routine clinical care.
  • Women known to be pregnant.
  • Non-English speaking, students, prisoners.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Joleen Hubbard, M.D.

Contact us for the latest status

Contact information:

Cancer Center Clinical Trials Referral Office

(855) 776-0015

More information

Publications

Publications are currently not available

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CLS-20467370

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