MRI to Assess Fibrosis in Eosinophilic Esophagitis Patients

Overview

About this study

Can an MRI detect and monitor the inflammatory and fibrotic possess in patients with Eosinophilic Esophagitis

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Adults ages 18-70 years of age
Diagnosis of EoE, i.e. symptoms of esophageal dysfunction with histologic finding of 15 or more eosinophils per high power field on esophageal biopsy despite 8 weeks of high dose proton pump inhibitor therapy.
All Subjects diagnosed with Eosinophilic Esophagitis pre and pose therapy

Exclusion Criteria:

Clinical evidence of infectious process potentially contributing to dysphagia (e.g. candidiasis, CMV, herpes)
Other cause of dysphagia identified at endoscopy or esophagram (e.g. reflux esophagitis, stricture, web, ring, achalasia, esophageal neoplasm)
Esophageal minimal diameter < 13 mm on structured barium esophagram
Inability to read due to: Blindness, cognitive dysfunction, or English language illiteracy
Pregnant women
Presence of body metallic fragments or devices that prohibit use of MRI
History of renal disease
eGRF <30

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Jeff Fidler, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Jeff Fidler, M.D.

Closed for enrollment

More information

Publications

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