Mechanisms of Eye Pressure Changes

Overview

About this study

To determine the reasons why eye pressure varies over time and between individuals. For patients with glaucoma, we are also trying to determine the mechanisms that control changes in eye pressure with the disease and standard treatments.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

General Inclusion for all

Patients of the Ophthalmology Department at Mayo Clinic Rochester
Patients with and without glaucoma will be included
Patients with chronic disease (e.g. hypertension) will be included as long as:
- Condition is stable
- Does not require treatment other than medications
- Are not using systemic steroids or medications known to affect aqueous humor flow rate (particularly beta-adrenergic blocking agents)

Genetics of Aqueous Humor Dynamics

Subjects for this portion of the study will be recruited from participants in the Hereditary Eye Diseases (HED) study (PI – Dr. A.O. Edwards; IRB #06-007210) who have previously had genotyping performed as part of that study

Aqueous Humor Dynamics of Ocular Hypertension and Glaucoma

Subjects for this portion of the study will be recruited from untreated newly diagnosed OHT and OAG patients of the Ophthalmology Department.

Aqueous Humor Dynamics of Trabectome Surgery

Subjects for this study will be recruited from phakic patients who are scheduled to undergo Trabectome ab interno trabeculectomy
Subjects must be in good general health

Characterizing the Reproducibility of EVP Measurements in Humans

Subjects will be recruited from students, employees and patients of Mayo Clinic and local area residents
Males and females between the ages of 18-65
Subjects with chronic disease (e.g. hypertension) will be included if
- Their condition is stable
- Does not require treatment other than medications
- Are not using systemic medications known to affect aqueous humor flow rate or IOP (steroids, beta-blockers, diuretics)

Exclusion Criteria:

General exclusion for all

Any history of intraocular:
- Ssurgery or trauma
- Narrow angles
- Uveitis
- Myopia greater than -4.00D
- Hyperopia greater than +2.00D
Pregnant or nursing women

Aqueous Humor Dynamics of Ocular Hypertension and Glaucoma

Subjects with advanced glaucoma or IOP>35 mmHg

Aqueous Humor Dynamics of Trabectome Surgery

Patients with end-stage glaucoma or evidence of corneal edema will also be excluded

Characterizing the Reproducibility of EVP Measurements in Humans

Any history of ocular pathology including
- Intraocular surgery or trauma
- Narrow angles, glaucoma
- Diabetic eye disease
- Uveitis
- Herpetic eye disease
- Myopia greater than -4.00D, or hyperopia greater than +2.00D

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Arthur Sit, M.D.	Closed for enrollment	Contact information: Hamad Gul (507) 284-5833 Gul.Hamad@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Arthur Sit, M.D.

Closed for enrollment

Contact information:

Hamad Gul

(507) 284-5833

Gul.Hamad@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials