Cough Reflex Sensitivity and Bronchial Hyper-responsiveness

Overview

About this study

The aim of this study is to provide pilot data on the possible gastrointestinal predictors of respiratory hyper-responsiveness and how these relate to the clinical sub-types of GERD and visceral acid hypersensitivity.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

symptomatic reflux(ie one symptom at least one day a week, with at least 'moderate' severity)
no evidence of esophagitis
non-smokers

Exclusion Criteria:

previous gastrointestinal surgery (excluding minor surgeries, such as cholecystectomy, appendectomy
active peptic ulcer disease
Zollinger Ellison Syndrome
Barrett's esophagus
eosinophilic esophagitis
cardiac disease
diabetes or neurological deficit
use of tricyclics
selective serotonin reuptake inhibitors
narcotics or benzodiazepines
current use of medications that may affect symptoms of perception,lower esophageal sphincter basal pressure, acid clearance time or acid suppression
antibiotics within 60 days
Nursing mothers will be excluded
allergies to citrus
asthma
chronic lung disease
heart attack or stroke within the last three months
hypersensitivity to methacholine products
know aortic aneurysm
uncontrolled hypertension (defined as systolic pressure greater than 200 or diastolic greater than 100)
reduced pulmonary function test (forced expiratory volume in one second [FEV1] or the FEV1 to forced vital capacity [FEV1/FVC] ratio of less that 70% of predicted value)
None of the controls will have any GERD symptoms or ever used antireflux treatment.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Jacksonville, Fla. Mayo Clinic principal investigator Kenneth DeVault, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Jacksonville, Fla.

Mayo Clinic principal investigator

Kenneth DeVault, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Clinical Trials