Study of Sc-FOS for Pouchitis Prevention

Overview

About this study

The main objective is to compare prebiotic therapy with placebo for the prevention of pouchitis after closure of diverting ileostomy in patients with an ileal pouch anal anastomosis. This study will also characterize the effects of prebiotics on the fecal microbiota and fecal microbial metabolites and correlate these effects with the primary outcome of development of pouchitis.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion criteria:

Age 18-65 years.
History of ulcerative colitis
Ileostomy closure after IPAA
Ability to give appropriate consent

Exclusion Criteria:

Crohn's disease.
Perianal disease (including abscess, fissure, or stricture)
Pregnancy
Lactation
Concurrent treatment for IBD or pouchitis

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status
Rochester, Minn. Mayo Clinic principal investigator Laura Raffals, M.D.	Closed for enrollment

Mayo Clinic Location

Status

Rochester, Minn.

Mayo Clinic principal investigator

Laura Raffals, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Clinical Trials