Modulation of Esophageal Inflammation in Barrett's Esophagus by Omega-3 Fatty Acids

Overview

About this study

Will oral supplementation with Omega 3 free fatty acids in obese Barrett's esophagus subjects downregulate pro-neoplastic and pro-inflammatory pathways in the esophagus to anti-inflammatory pathway?

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

Presence of BE defined as ≥ 1 cm of visible columnar mucosa in the distal esophagus with intestinal metaplasia on histology.
Absence of high grade dysplasia or EAC on baseline histology.
BMI > 30 kg/m2 or Waist circumference > 102 cm in men, > 88 cm in women.
Ability to give informed consent.

Exclusion Criteria

Allergy to ω3 FFAs, fish or shellfish.
Presence of high grade dysplasia or cancer on histology.
Pregnant and or breastfeeding women
Presence of esophagitis on initial endoscopy or symptoms of refractory GERD (heartburn or regurgitation ≥ 2 times a week) indicative of uncontrolled gastroesophageal reflux.
Inability to give informed consent.
Currently taking Omega3 FFA as prescription
Anti-coagulant therapy (Plavix, Warfarin, Coumadin)
AST or ALT level > three times upper limit of normal at baseline
LDL > 200 mg/dl at baseline.
INR > 2

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Prasad Iyer, M.D.	Closed for enrollment	Contact information: Michele Johnson P.T.A., CCRP (507)255-8692 johnson.michele@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Prasad Iyer, M.D.

Closed for enrollment

Contact information:

Michele Johnson P.T.A., CCRP

(507)255-8692

johnson.michele@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials