Faculty

Barry A. Borlaug, M.D.

Publications

Monzo L, Kovar J, Borlaug BA, Benes J, Kotrc M, Kroupova K, Jabor A, Franekova J, Melenovsky V. Circulating beta-hydroxybutyrate levels in advanced heart failure with reduced ejection fraction: Determinants and prognostic impact. Eur J Heart Fail. 2024 Jun 10 Epub 2024 June 10
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Borlaug BA, Larive B, Frantz RP, Hassoun P, Hemnes A, Horn E, Leopold J, Rischard F, Berman-Rosenzweig E, Beck G, Erzurum S, Farha S, Finet JE, Highland KB, Jacob M, Jellis C, Mehra R, Renapurkar R, Singh H, Tang WHW, Vanderpool R, Wilcox J, Yu S, Hill N. Pulmonary hypertension across the spectrum of left heart and lung disease. Eur J Heart Fail. 2024 Jun 4 Epub 2024 June 04
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Harada T, Naser JA, Tada A, Doi S, Ibe T, Pislaru SV, Eleid MF, Sorimachi H, Obokata M, Reddy YNV, Borlaug BA. Cardiac function, haemodynamics, and valve competence with exercise in patients with heart failure with preserved ejection fraction and mild to moderate secondary mitral regurgitation. Eur J Heart Fail. 2024 Jun 4 Epub 2024 June 04
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Henry JA, Abdesselam I, Deal O, Lewis AJ, Rayner J, Bernard M, Dutour A, Gaborit B, Kober F, Soghomonian A, Sgromo B, Byrne J, Bege T, Borlaug BA, Neubauer S, Rider OJ. The effect of bariatric surgery type on cardiac reverse remodelling. Int J Obes (Lond). 2024 Jun; 48 (6):808-814 Epub 2024 Jan 31
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Patel RB, Silvestry FE, Komtebedde J, Solomon SD, Hasenfuss G, Litwin SE, Borlaug BA, Price MJ, Kawash R, Hummel SL, Cutlip DE, Leon MB, van Veldhuisen DJ, Rieth AJ, McKenzie S, Bugger H, Mazurek JA, Kapadia SR, Vanderheyden M, Ky B, Shah SJ. Atrial Shunt Device Effects on Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction: The REDUCE LAP-HF II Randomized Clinical Trial. JAMA Cardiol. 2024 Jun 1; 9 (6):507-522
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Selvaraj S, Patel S, Sauer AJ, McGarrah RW, Jones P, Kwee LC, Windsor SL, Ilkayeva O, Muehlbauer MJ, Newgard CB, Borlaug BA, Kitzman DW, Shah SJ, Shah SH, Kosiborod MN, PRESERVED-HF Investigators. Targeted Metabolomic Profiling of Dapagliflozin in Heart Failure With Preserved Ejection Fraction: The PRESERVED-HF Trial. JACC Heart Fail. 2024 Jun; 12 (6):999-1011 Epub 2024 Apr 17
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Reddy YNV, Noseworthy P, Borlaug BA, Albert NM. Screening for Unrecognized HFpEF in Atrial Fibrillation and for Unrecognized Atrial Fibrillation in HFpEF. JACC Heart Fail. 2024 Jun; 12 (6):990-998
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Hammer SM, Bruhn EJ, Bissen TG, Cifci G, Borlaug BA, Olson TP, Smith JR. Impaired Vastus Lateralis Blood Flow During Cycling Exercise in Heart Failure With Preserved Ejection Fraction. J Card Fail. 2024 May 20 [Epub ahead of print]
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Tada A, Doi S, Harada T, Ibe T, Naser JA, Amdahl M, Reddy YNV, Borlaug BA. Autoimmune Disorders in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail. 2024 May 16 [Epub ahead of print]
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Shah SJ, Sharma K, Borlaug BA, Butler J, Davies M, Kitzman DW, Petrie MC, Verma S, Patel S, Chinnakondepalli KM, Einfeldt MN, Jensen TJ, Rasmussen S, Asleh R, Ben-Gal T, Kosiborod MN. Semaglutide and Diuretic Use in Obesity-Related Heart Failure with Preserved Ejection Fraction: A Pooled Analysis of the STEP-HFpEF and STEP-HFpEF-DM trials. Eur Heart J. 2024 May 13 [Epub ahead of print]
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Petrie MC, Borlaug BA, Butler J, Davies MJ, Kitzman DW, Shah SJ, Verma S, Jensen TJ, Einfeldt MN, Liisberg K, Perna E, Sharma K, Ezekowitz JA, Fu M, Melenovsky V, Ito H, Lelonek M, Kosiborod MN, STEP-HFpEF Trial Committees and Investigators. Semaglutide and NT-proBNP in Obesity-Related HFpEF: Insights From the STEP-HFpEF Program. J Am Coll Cardiol. 2024 May 13 [Epub ahead of print]
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Berg-Hansen K, Gopalasingam N, Christensen KH, Ladefoged B, Andersen MJ, Poulsen SH, Borlaug BA, Nielsen R, Moller N, Wiggers H. Cardiovascular Effects of Oral Ketone Ester Treatment in Patients With Heart Failure With Reduced Ejection Fraction: A Randomized, Controlled, Double-Blind Trial. Circulation. 2024 May 7; 149 (19):1474-1489 Epub 2024 Mar 27
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Butler J, Shah SJ, Petrie MC, Borlaug BA, Abildstrom SZ, Davies MJ, Hovingh GK, Kitzman DW, Moller DV, Verma S, Einfeldt MN, Lindegaard ML, Rasmussen S, Abhayaratna W, Ahmed FZ, Ben-Gal T, Chopra V, Ezekowitz JA, Fu M, Ito H, Lelonek M, Melenovsky V, Merkely B, Nunez J, Perna E, Schou M, Senni M, Sharma K, van der Meer P, Von Lewinski D, Wolf D, Kosiborod MN, STEP-HFpEF Trial Committees and Investigators. Semaglutide versus placebo in people with obesity-related heart failure with preserved ejection fraction: a pooled analysis of the STEP-HFpEF and STEP-HFpEF DM randomised trials. Lancet. 2024 Apr 27; 403 (10437):1635-1648 Epub 2024 Apr 07
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Naser JA, Alexandrino FB, Harada T, Michelena HI, Borlaug BA, Eleid MF, Lin G, Scott C, Kennedy AM, Pellikka PA, Nkomo VT, Pislaru SV. The Natural History of Atrial Functional Mitral Regurgitation. J Am Coll Cardiol. 2024 Apr 23; 83 (16):1495-1507 Epub 2024 Mar 25
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Kosiborod MN, Petrie MC, Borlaug BA, Butler J, Davies MJ, Hovingh GK, Kitzman DW, Moller DV, Treppendahl MB, Verma S, Jensen TJ, Liisberg K, Lindegaard ML, Abhayaratna W, Ahmed FZ, Ben-Gal T, Chopra V, Ezekowitz JA, Fu M, Ito H, Lelonek M, Melenovsky V, Merkely B, Nunez J, Perna E, Schou M, Senni M, Sharma K, van der Meer P, Von Lewinski D, Wolf D, Shah SJ, STEP-HFpEF DM Trial Committees and Investigators. Semaglutide in Patients with Obesity-Related Heart Failure and Type 2 Diabetes. N Engl J Med. 2024 Apr 18; 390 (15):1394-1407 Epub 2024 Apr 06
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Monzo L, Tupy M, Borlaug BA, Reichenbach A, Jurcova I, Benes J, Mlateckova L, Ters J, Kautzner J, Melenovsky V. Pressure overload is associated with right ventricular dyssynchrony in heart failure with reduced ejection fraction. ESC Heart Fail. 2024 Apr; 11 (2):1097-1109 Epub 2024 Jan 23
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Borlaug BA, Strong M. Heart Failure Solutions: The PeriCut Device as a Treatment for HFpEF. JACC Basic Transl Sci. 2024 Apr; 9 (4):448-450 Epub 2024 Apr 22
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Ameri P, Mercurio V, Pollesello P, Anker MS, Backs J, Bayes-Genis A, Borlaug BA, Burkhoff D, Caravita S, Chan SY, de Man F, Giannakoulas G, Gonzalez A, Guazzi M, Hassoun PM, Hemnes AR, Maack C, Madden B, Melenovsky V, Muller OJ, Papp Z, Pullamsetti SS, Rainer PP, Redfield MM, Rich S, Schiattarella GG, Skaara H, Stellos K, Tedford RJ, Thum T, Vachiery JL, van der Meer P, Van Linthout S, Pruszczyk P, Seferovic P, Coats AJS, Metra M, Rosano G, Rosenkranz S, Tocchetti CG. A roadmap for therapeutic discovery in pulmonary hypertension associated with left heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Pulmonary Circulation & Right Ventricular Function. Eur J Heart Fail. 2024 Apr; 26 (4):707-729 Epub 2024 Apr 19
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Borlaug BA, Kindel TL. Obesity and Heart Failure: A New Era Begins. J Card Fail. 2024 Mar 4 Epub 2024 Mar 04
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Larson K, Omar M, Sorimachi H, Omote K, Alogna A, Popovic D, Tada A, Doi S, Naser J, Reddy YNV, Redfield MM, Borlaug BA. Clinical phenogroup diversity and multiplicity: Impact on mechanisms of exercise intolerance in heart failure with preserved ejection fraction. Eur J Heart Fail. 2024 Mar; 26 (3):564-577 Epub 2024 Jan 18
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Hoedemakers S, Verwerft J, Reddy YNV, Delvaux R, Stroobants S, Jogani S, Claessen G, Droogmans S, Cosyns B, Borlaug BA, Herbots L, Verbrugge FH. Cardiac dysfunction rather than aortic valve stenosis severity drives exercise intolerance and adverse haemodynamics. Eur Heart J Cardiovasc Imaging. 2024 Feb 22; 25 (3):302-312
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Miranda WR, Jain CC, Borlaug BA, Connolly HM, Burchill LJ, Van De Bruaene A, Egbe AC. Exercise catheterization in adults post-Fontan with normal and abnormal haemodynamic criteria: Insights into normal Fontan physiology. Eur J Heart Fail. 2024 Feb; 26 (2):314-323 Epub 2024 Feb 01
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Borlaug BA, Koepp KE, Reddy YNV, Obokata M, Sorimachi H, Freund M, Haberman D, Sweere K, Weber KL, Overholt EA, Safe BA, Omote K, Omar M, Popovic D, Acker NG, Gladwin MT, Olson TP, Carter RE. Inorganic Nitrite to Amplify the Benefits and Tolerability of Exercise Training in Heart Failure With Preserved Ejection Fraction: The INABLE-Training Trial. Mayo Clin Proc. 2024 Feb; 99 (2):206-217 Epub 2023 Dec 21
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Omote K, Sorimachi H, Obokata M, Verbrugge FH, Omar M, Popovic D, Reddy YNV, Pislaru SV, Pellikka PA, Borlaug BA. Biatrial myopathy in heart failure with preserved ejection fraction. Eur J Heart Fail. 2024 Feb; 26 (2):288-298 Epub 2023 Dec 13
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Egbe AC, Younis A, Miranda WR, Jain CC, Connolly HM, Borlaug BA. Determinants and prognostic implications of left atrial reverse remodelling after coarctation of aorta repair in adults. Eur Heart J Cardiovasc Imaging. 2024 Jan 29; 25 (2):249-256
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Kosiborod MN, Verma S, Borlaug BA, Butler J, Davies MJ, Jon Jensen T, Rasmussen S, Erlang Marstrand P, Petrie MC, Shah SJ, Ito H, Schou M, Melenovsky V, Abhayaratna W, Kitzman DW, STEP-HFpEF Trial Committees and Investigators. Effects of Semaglutide on Symptoms, Function, and Quality of Life in Patients With Heart Failure With Preserved Ejection Fraction and Obesity: A Prespecified Analysis of the STEP-HFpEF Trial. Circulation. 2024 Jan 16; 149 (3):204-216 Epub 2023 Nov 12
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Fudim M, Litwin SE, Borlaug BA, Mohan RC, Price MJ, Fail P, Zirakashvili T, Shaburishvili T, Goyal P, Hummel SL, Patel RB, Reddy VY, Burkhoff D, Patel MR, Somo SI, Shah SJ. Endovascular Ablation of the Right Greater Splanchnic Nerve in Heart Failure With Preserved Ejection Fraction: Rationale, Design and Lead-in Phase Results of the REBALANCE-HF Trial. J Card Fail. 2024 Jan 9 Epub 2024 Jan 09
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Lee E, Ito S, Miranda WR, Lopez-Jimenez F, Kane GC, Asirvatham SJ, Noseworthy PA, Friedman PA, Carter RE, Borlaug BA, Attia ZI, Oh JK. Artificial intelligence-enabled ECG for left ventricular diastolic function and filling pressure. NPJ Digit Med. 2024 Jan 6; 7 (1):4 Epub 2024 Jan 06
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Alogna A, Berboth L, Faragli A, Otvos J, Lo Muzio FP, di Mauro V, Modica J, Quarta E, Semmler L, Deissler PM, Berger YW, Tran KL, de Marchi B, Longinotti-Buitoni G, Degli Esposti L, Guillot E, Bazile D, Iafisco M, Dotti A, Bang ML, de Luca C, Brandenberger C, Benazzi L, di Silvestre D, de Palma A, Primessnig U, Hohendanner F, Perna S, Buttini F, Colombo P, Muhlfeld C, Steendijk P, Mauri P, Tschope C, Borlaug B, Pieske BM, Attanasio P, Post H, Heinzel FR, Catalucci D. Lung-to-Heart Nano-in-Micro Peptide Promotes Cardiac Recovery in a Pig Model of Chronic Heart Failure. J Am Coll Cardiol. 2024 Jan 2; 83 (1):47-59
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Litwin SE, Komtebedde J, Seidler T, Borlaug BA, Winkler S, Solomon SD, Eicher JC, Mazimba S, Khawash R, Sverdlov AL, Hummel SL, Bugger H, Boenner F, Hoendermis E, Cikes M, Demers C, Silva G, van Empel V, Starling RC, Penicka M, Cutlip DE, Leon MB, Kitzman DW, van Veldhuisen DJ, Shah SJ, REDUCE LAP-HF Investigators and Research Staff. Obesity in heart failure with preserved ejection fraction: Insights from the REDUCE LAP-HF II trial. Eur J Heart Fail. 2024 Jan; 26 (1):177-189 Epub 2023 Dec 07
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Naser JA, Lee E, Scott CG, Kennedy AM, Pellikka PA, Lin G, Pislaru SV, Borlaug BA. Prevalence and incidence of diastolic dysfunction in atrial fibrillation: clinical implications. Eur Heart J. 2023 Dec 21; 44 (48):5049-5060
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Butler J, Abildstrom SZ, Borlaug BA, Davies MJ, Kitzman DW, Petrie MC, Shah SJ, Verma S, Abhayaratna WP, Chopra V, Ezekowitz JA, Fu M, Ito H, Lelonek M, Nunez J, Perna E, Schou M, Senni M, van der Meer P, von Lewinski D, Wolf D, Altschul RL, Rasmussen S, Kosiborod MN. Semaglutide in Patients With Obesity and Heart Failure Across Mildly Reduced or Preserved Ejection Fraction. J Am Coll Cardiol. 2023 Nov 28; 82 (22):2087-2096 Epub 2023 Oct 08
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Borlaug BA, Schaff HV, Asirvatham SJ, Koepp KE, Mauermann WJ, Rowse PG. Surgical pericardiotomy to treat heart failure with preserved ejection fraction: a first clinical study. Eur Heart J. 2023 Nov 21; 44 (44):4719-4721
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Alogna A, Koepp KE, Sabbah M, Espindola Netto JM, Jensen MD, Kirkland JL, Lam CSP, Obokata M, Petrie MC, Ridker PM, Sorimachi H, Tchkonia T, Voors A, Redfield MM, Borlaug BA. Interleukin-6 in Patients With Heart Failure and Preserved Ejection Fraction. JACC Heart Fail. 2023 Nov; 11 (11):1549-1561 Epub 2023 Aug 09
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Lewis GD, Gosch K, Cohen LP, Nassif ME, Windsor SL, Borlaug BA, Kitzman DW, Shah SJ, Khumri T, Umpierrez G, Lamba S, Sharma K, Khan SS, Kosiborod MN, Sauer AJ. Effect of Dapagliflozin on 6-Minute Walk Distance in Heart Failure With Preserved Ejection Fraction: PRESERVED-HF. Circ Heart Fail 2023 Nov; 16 (11):e010633 Epub 2023 Oct 23
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Verma S, Borlaug BA, Butler J, Davies MJ, Kitzman DW, Petrie MC, Shah SJ, Dhingra NK, Kosiborod MN. A big STEP for treatment of heart failure with preserved ejection fraction. Cell Metab. 2023 Oct 3; 35 (10):1681-1687 Epub 2023 Aug 28
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Morgen CS, Haase CL, Oral TK, Schnecke V, Varbo A, Borlaug BA. Obesity, Cardiorenal Comorbidities, and Risk of Hospitalization in Patients With Heart Failure With Preserved Ejection Fraction. Mayo Clin Proc. 2023 Oct; 98 (10):1458-1468 Epub 2023 Aug 09
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Kosiborod MN, Abildstrom SZ, Borlaug BA, Butler J, Rasmussen S, Davies M, Hovingh GK, Kitzman DW, Lindegaard ML, Moller DV, Shah SJ, Treppendahl MB, Verma S, Abhayaratna W, Ahmed FZ, Chopra V, Ezekowitz J, Fu M, Ito H, Lelonek M, Melenovsky V, Merkely B, Nunez J, Perna E, Schou M, Senni M, Sharma K, Van der Meer P, von Lewinski D, Wolf D, Petrie MC, STEP-HFpEF Trial Committees and Investigators. Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity. N Engl J Med. 2023 Sep 21; 389 (12):1069-1084 Epub 2023 Aug 25
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Borlaug BA, Reddy YNV, Braun A, Sorimachi H, Omar M, Popovic D, Alogna A, Jensen MD, Carter R. Cardiac and Metabolic Effects of Dapagliflozin in Heart Failure With Preserved Ejection Fraction: The CAMEO-DAPA Trial. Circulation. 2023 Sep 5; 148 (10):834-844 Epub 2023 Aug 03
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Keck C, Gregoski M, Litwin S, Borlaug BA, Fudim M, Tedford RJ, Houston BA. Decoupling of Hemodynamics and Congestive Symptoms in Obese Patients With Heart Failure. J Card Fail. 2023 Sep; 29 (9):1249-1256 Epub 2023 Mar 23
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Borlaug BA, Kitzman DW, Davies MJ, Rasmussen S, Barros E, Butler J, Einfeldt MN, Hovingh GK, Moller DV, Petrie MC, Shah SJ, Verma S, Abhayaratna W, Ahmed FZ, Chopra V, Ezekowitz J, Fu M, Ito H, Lelonek M, Melenovsky V, Nunez J, Perna E, Schou M, Senni M, van der Meer P, Von Lewinski D, Wolf D, Kosiborod MN. Semaglutide in HFpEF across obesity class and by body weight reduction: a prespecified analysis of the STEP-HFpEF trial. Nat Med. 2023 Sep; 29 (9):2358-2365 Epub 2023 Aug 27
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Warner B, Bruhn EJ, Olson TP, Bissen TG, Borlaug BA, Smith JR. Inspiratory muscle strength is related to exertional dyspnoea in heart failure with preserved ejection fraction. Eur J Heart Fail 2023 Sep; 25 (9):1716-1717 Epub 2023 Aug 02
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Omar M, Omote K, Sorimachi H, Popovic D, Kanwar A, Alogna A, Reddy YNV, Lim KG, Shah SJ, Borlaug BA. Hypoxaemia in patients with heart failure and preserved ejection fraction. Eur J Heart Fail. 2023 Sep; 25 (9):1593-1603 Epub 2023 June 27
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Borlaug BA, Testani JM. SGLT2 inhibitors and diuretics in heart failure: clicking reset on the renal volume setpoint? Eur Heart J 2023 Aug 14; 44 (31):2944-2946
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Litwin SE, Komtebedde J, Hu M, Burkhoff D, Hasenfuss G, Borlaug BA, Solomon SD, Zile MR, Mohan RC, Khawash R, Sverdlov AL, Fail P, Chung ES, Kaye DM, Blair J, Eicher JC, Hummel SL, Zirlik A, Westenfeld R, Hayward C, Gorter TM, Demers C, Shetty R, Lewis G, Starling RC, Patel S, Gupta DK, Morsli H, Penicka M, Cikes M, Gustafsson F, Silvestry FE, Rowin EJ, Cutlip DE, Leon MB, Kitzman DW, Kleber FX, Shah SJ, REDUCE LAP-HF Investigators and Research Staff. Exercise-Induced Left Atrial Hypertension in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail. 2023 Aug; 11 (8 Pt 2):1103-1117 Epub 2023 Mar 20
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Egbe AC, Miranda WR, Connolly HM, Kullo IJ, Borlaug BA. Daytime Versus Nighttime Ambulatory Blood Pressure Monitoring in Coarctation of Aorta. Hypertension. 2023 Aug; 80 (8):e134-e136 Epub 2023 May 10
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Kosiborod MN, Abildstrom SZ, Borlaug BA, Butler J, Christensen L, Davies M, Hovingh KG, Kitzman DW, Lindegaard ML, Moller DV, Shah SJ, Treppendahl MB, Verma S, Petrie MC. Design and Baseline Characteristics of STEP-HFpEF Program Evaluating Semaglutide in Patients With Obesity HFpEF Phenotype. JACC Heart Fail. 2023 Aug; 11 (8 Pt 1):1000-1010 Epub 2023 May 21
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Omote K, Borlaug BA. Left Atrial Myopathy in Heart Failure With Preserved Ejection Fraction. Circ J. 2023 Jul 25; 87 (8):1039-1046 Epub 2021 Oct 12
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Alogna A, Omar M, Popovic D, Sorimachi H, Omote K, Reddy YNV, Pieske B, Borlaug BA. Biventricular cardiac power reserve in heart failure with preserved ejection fraction. Eur J Heart Fail. 2023 Jul; 25 (7):956-966 Epub 2023 Apr 24
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Nassif ME, Windsor SL, Gosch K, Borlaug BA, Husain M, Inzucchi SE, Kitzman DW, McGuire DK, Pitt B, Scirica BM, Shah SJ, Umpierrez G, Austin BA, Lamba S, Khumri T, Sharma K, Kosiborod MN. Dapagliflozin Improves Heart Failure Symptoms and Physical Limitations Across the Full Range of Ejection Fraction: Pooled Patient-Level Analysis From DEFINE-HF and PRESERVED-HF Trials. Circ Heart Fail. 2023 Jul; 16 (7):e009837 Epub 2023 May 19
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Reddy YNV, Borlaug BA. Rate-Adaptive Atrial Pacing for Heart Failure With Preserved Ejection Fraction-Reply. JAMA 2023 Jun 20; 329 (23):2096-2097
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Eder M, Griffin M, Moreno-Villagomez J, Bellumkonda L, Maulion C, Asher J, Wilson FP, Cox ZL, Ivey-Miranda JB, Rao VS, Butler J, Borlaug BA, McCallum W, Ramos-Mastache D, Testani JM. The importance of forward flow and venous congestion in diuretic response in acute heart failure: Insights from the ESCAPE trial. Int J Cardiol. 2023 Jun 15; 381:57-61 Epub 2023 Apr 05
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Martens P, Yu S, Larive B, Borlaug BA, Erzurum SC, Farha S, Finet JE, Grunig G, Hemnes AR, Hill NS, Horn EM, Jacob M, Kwon DH, Park MM, Rischard FP, Rosenzweig EB, Wilcox JD, Tang WHW, PVDOMICS Study Group. Iron deficiency in pulmonary vascular disease: pathophysiological and clinical implications. Eur Heart J. 2023 Jun 9; 44 (22):1979-1991
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Gard EK, Beale AL, Telles F, Silvestry FE, Hanff T, Hummel SL, Litwin SE, Petrie MC, Shah SJ, Borlaug BA, Burkhoff D, Komtebedde J, Kaye DM, Nanayakkara S. Left atrial enlargement is associated with pulmonary vascular disease in heart failure with preserved ejection fraction. Eur J Heart Fail. 2023 Jun; 25 (6):806-814 Epub 2023 Mar 15
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Borlaug BA, Sharma K, Shah SJ, Ho JE. Heart Failure With Preserved Ejection Fraction: JACC Scientific Statement. J Am Coll Cardiol. 2023 May 9; 81 (18):1810-1834 Epub 2023 Apr 19
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Sheridan WS, Wetterling F, Testani JM, Borlaug BA, Fudim M, Damman K, Gray A, Gaines P, Poloczek M, Madden S, Tucker J, Buxo T, Gaul R, Corcoran L, Sweeney F, Burkhoff D. Safety and performance of a novel implantable sensor in the inferior vena cava under acute and chronic intravascular volume modulation. Eur J Heart Fail. 2023 May; 25 (5):754-763 Epub 2023 Mar 09
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Popovic D, Alogna A, Omar M, Sorimachi H, Omote K, Reddy YNV, Redfield MM, Burkhoff D, Borlaug BA. Ventricular stiffening and chamber contracture in heart failure with higher ejection fraction. Eur J Heart Fail. 2023 May; 25 (5):657-668 Epub 2023 Apr 12
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Miranda WR, Jain CC, Borlaug BA, Jaffe AS, Connolly HM, Burchill LJ, Egbe AC. Exercise Capacity, NT-proBNP, and Exercise Hemodynamics in Adults Post-Fontan. J Am Coll Cardiol. 2023 Apr 25; 81 (16):1590-1600
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Posada-Martinez EL, Cox ZL, Cano-Nieto MM, Ibarra-Marquez ND, Moreno-Villagomez J, Gudino-Bravo P, Arias-Godinez JA, Lopez-Gil S, Madero M, Rao VS, Mebazaa A, Burkhoff D, Cowie MR, Fudim M, Damman K, Borlaug BA, Testani JM, Ivey-Miranda JB. Changes in the Inferior Vena Cava Are More Sensitive Than Venous Pressure During Fluid Removal: A Proof-of-Concept Study. J Card Fail. 2023 Apr; 29 (4):463-472 Epub 2022 Oct 13
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Pugliese NR, De Biase N, Del Punta L, Balletti A, Armenia S, Buralli S, Mengozzi A, Taddei S, Metra M, Pagnesi M, Borlaug BA, Williams B, Masi S. Deep phenotype characterization of hypertensive response to exercise: implications on functional capacity and prognosis across the heart failure spectrum. Eur J Heart Fail. 2023 Apr; 25 (4):497-509 Epub 2023 Mar 29
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Fayyaz AU, Sabbah MS, Dasari S, Griffiths LG, DuBrock HM, Wang Y, Charlesworth MC, Borlaug BA, Jenkins SM, Edwards WD, Redfield MM. Histologic and proteomic remodeling of the pulmonary veins and arteries in a porcine model of chronic pulmonary venous hypertension. Cardiovasc Res. 2023 Mar 17; 119 (1):268-282
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Reddy YNV, Koepp KE, Carter R, Win S, Jain CC, Olson TP, Johnson BD, Rea R, Redfield MM, Borlaug BA. Rate-Adaptive Atrial Pacing for Heart Failure With Preserved Ejection Fraction: The RAPID-HF Randomized Clinical Trial. JAMA. 2023 Mar 14; 329 (10):801-809
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Redfield MM, Borlaug BA. Heart Failure With Preserved Ejection Fraction: A Review. JAMA. 2023 Mar 14; 329 (10):827-838
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Natov PS, Ivey-Miranda JB, Cox ZL, Moreno-Villagomez J, Maulion C, Bellumkonda L, Shlipak MG, Estrella MM, Borlaug BA, Rao VS, Testani JM. Improvement in Renal Function During the Treatment of Acute Decompensated Heart Failure: Relationship With Markers of Renal Tubular Injury and Prognostic Importance. Circ Heart Fail. 2023 Mar; 16 (3):e009776 Epub 2023 Jan 26
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Borlaug BA, Jensen MD, Kitzman DW, Lam CSP, Obokata M, Rider OJ. Obesity and heart failure with preserved ejection fraction: new insights and pathophysiological targets. Cardiovasc Res. 2023 Feb 3; 118 (18):3434-3450
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Peters AE, Tromp J, Shah SJ, Lam CSP, Lewis GD, Borlaug BA, Sharma K, Pandey A, Sweitzer NK, Kitzman DW, Mentz RJ. Phenomapping in heart failure with preserved ejection fraction: insights, limitations, and future directions. Cardiovasc Res. 2023 Feb 3; 118 (18):3403-3415
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Dong X, Strudwick M, Wang WY, Borlaug BA, van der Geest RJ, Ng AC, Delgado V, Bax JJ, Ng AC. Impact of body mass index and diabetes on myocardial fat content, interstitial fibrosis and function. Int J Cardiovasc Imaging. 2023 Feb; 39 (2):379-390 Epub 2022 Oct 28
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Omote K, Verbrugge FH, Sorimachi H, Omar M, Popovic D, Obokata M, Reddy YNV, Borlaug BA. Central haemodynamic abnormalities and outcome in patients with unexplained dyspnoea. Eur J Heart Fail. 2023 Feb; 25 (2):185-196 Epub 2022 Dec 15
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Miranda WR, Borlaug BA, Jain CC, Anderson JH, Hagler DJ, Connolly HM, Egbe AC. Exercise-induced changes in pulmonary artery wedge pressure in adults post-Fontan versus heart failure with preserved ejection fraction and non-cardiac dyspnoea. Eur J Heart Fail. 2023 Jan; 25 (1):17-25 Epub 2022 Oct 23
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Henry JA, Abdesselam I, Deal O, Lewis AJ, Rayner J, Bernard M, Dutour A, Gaborit B, Kober F, Soghomonian A, Sgromo B, Byrne J, Bege T, Neubauer S, Borlaug BA, Rider OJ. Changes in epicardial and visceral adipose tissue depots following bariatric surgery and their effect on cardiac geometry. Front Endocrinol (Lausanne). 2023; 14:1092777 Epub 2023 Jan 25
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Egbe AC, Miranda WR, Jain CC, Borlaug BA, Connolly HM. Prognostic Implications of Exercise-Induced Hypertension in Adults With Repaired Coarctation of Aorta. Hypertension. 2022 Dec; 79 (12):2796-2805 Epub 2022 Oct 12
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Alexander C. Egbe, William R. Miranda, Yogesh N.V. Reddy, Jason H. Anderson, Kartik Andi, Ahmed Goda, Omar Abozied, Heidi M. Connolly, Barry A. Borlaug. Prognostic Value of the H2FPEF Score in Adults With Repaired Coarctation of Aorta JACC: Advances. 2022; 1(5).
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Wessler J, Kaye D, Gustafsson F, Petrie MC, Hasenfubeta G, Lam CSP, Borlaug BA, Komtebedde J, Feldman T, Shah SJ, Burkhoff D, REDUCE-LAP-HF Trial Investigators and Advisors. Impact of Baseline Hemodynamics on the Effects of a Transcatheter Interatrial Shunt Device in Heart Failure With Preserved Ejection Fraction. Circ Heart Fail. 2018 Aug; 11 (8):e004540
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Gorter TM, van Veldhuisen DJ, Bauersachs J, Borlaug BA, Celutkiene J, Coats AJS, Crespo-Leiro MG, Guazzi M, Harjola VP, Heymans S, Hill L, Lainscak M, Lam CSP, Lund LH, Lyon AR, Mebazaa A, Mueller C, Paulus WJ, Pieske B, Piepoli MF, Ruschitzka F, Rutten FH, Seferovic PM, Solomon SD, Shah SJ, Triposkiadis F, Wachter R, Tschope C, de Boer RA. Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2018 Jan; 20 (1):16-37 Epub 2017 Oct 16
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Reddy YNV, Obokata M, Haykowsky MJ, Borlaug BA. Skeletal Muscle Compensation for Cardiac Muscle Insufficiency in Heart Failure and Reduced Ejection Fraction. Circ Heart Fail. 2018 Jan; 11 (1):e004714
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Van Iterson EH, Johnson BD, Borlaug BA, Olson TP. Physiological dead space and arterial carbon dioxide contributions to exercise ventilatory inefficiency in patients with reduced or preserved ejection fraction heart failure. Eur J Heart Fail. 2017 Dec; 19 (12):1675-1685 Epub 2017 Oct 08
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Hemnes AR, Beck GJ, Newman JH, Abidov A, Aldred MA, Barnard J, Berman Rosenzweig E, Borlaug BA, Chung WK, Comhair SAA, Erzurum SC, Frantz RP, Gray MP, Grunig G, Hassoun PM, Hill NS, Horn EM, Hu B, Lempel JK, Maron BA, Mathai SC, Olman MA, Rischard FP, Systrom DM, Tang WHW, Waxman AB, Xiao L, Yuan JX, Leopold JA, PVDOMICS Study Group. PVDOMICS: A Multi-Center Study to Improve Understanding of Pulmonary Vascular Disease Through Phenomics. Circ Res. 2017 Oct 27; 121 (10):1136-1139
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Borlaug BA, Obokata M. Is it time to recognize a new phenotype? Heart failure with preserved ejection fraction with pulmonary vascular disease. Eur Heart J 2017 Oct 7; 38 (38):2874-2878
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Lloyd JW, Nishimura RA, Borlaug BA, Eleid MF. Hemodynamic Response to Nitroprusside in Patients With Low-Gradient Severe Aortic Stenosis and Preserved Ejection Fraction. J Am Coll Cardiol. 2017 Sep 12; 70 (11):1339-1348
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Van Iterson EH, Olson TP, Borlaug BA, Johnson BD, Snyder EM. Comparisons of Noninvasive Methods Used to Assess Exercise Stroke Volume in Heart Failure with Preserved Ejection Fraction. Med Sci Sports Exerc. 2017 Sep; 49 (9):1758-1768
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Melenovsky V, Benes J, Franekova J, Kovar J, Borlaug BA, Segetova M, Tura A, Pelikanova T. Glucose Homeostasis, Pancreatic Endocrine Function, and Outcomes in Advanced Heart Failure. J Am Heart Assoc. 2017 Aug 7; 6 (8) Epub 2017 Aug 07
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Reddy YNV, Andersen MJ, Obokata M, Koepp KE, Kane GC, Melenovsky V, Olson TP, Borlaug BA. Arterial Stiffening With Exercise in Patients With Heart Failure and Preserved Ejection Fraction. J Am Coll Cardiol. 2017 Jul 11; 70 (2):136-148
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Obokata M, Reddy YNV, Pislaru SV, Melenovsky V, Borlaug BA. Evidence Supporting the Existence of a Distinct Obese Phenotype of Heart Failure With Preserved Ejection Fraction. Circulation. 2017 Jul 4; 136 (1):6-19 Epub 2017 Apr 05
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Chandrashekar P, Park JY, Al-Hijji MA, Reddy YNV, Zack CJ, Reeder GS, Rea RF, Borlaug BA. Atrial Septostomy to Treat Stiff Left Atrium Syndrome. Circ Heart Fail. 2017 Jul; 10 (7)
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Reddy YNV, Obokata M, Dean PG, Melenovsky V, Nath KA, Borlaug BA. Long-term cardiovascular changes following creation of arteriovenous fistula in patients with end stage renal disease. Eur Heart J. 2017 Jun 21; 38 (24):1913-1923
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Givertz MM, Fang JC, Sorajja P, Dimas V, Forfia PR, Kapur NK, Kern MJ, Naidu SS, Borlaug BA. Executive Summary of the SCAI/HFSA Clinical Expert Consensus Document on the Use of Invasive Hemodynamics for the Diagnosis and Management of Cardiovascular Disease. J Card Fail. 2017 Jun; 23 (6):487-491 Epub 2017 Apr 25
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Sorajja P, Borlaug BA, Dimas V, Fang JC, Forfia PR, Givertz MM, Kapur NK, Kern MJ, Naidu SS. Executive summary of the SCAI/HFSA clinical expert consensus document on the use of invasive hemodynamics for the diagnosis and management of cardiovascular disease. Catheter Cardiovasc Interv. 2017 Jun 1; 89 (7):1294-1299 Epub 2017 May 10
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Reddy YNV, Lewis GD, Shah SJ, LeWinter M, Semigran M, Davila-Roman VG, Anstrom K, Hernandez A, Braunwald E, Redfield MM, Borlaug BA. INDIE-HFpEF (Inorganic Nitrite Delivery to Improve Exercise Capacity in Heart Failure With Preserved Ejection Fraction): Rationale and Design. Circ Heart Fail. 2017 May; 10 (5)
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Melenovsky V, Petrak J, Mracek T, Benes J, Borlaug BA, Nuskova H, Pluhacek T, Spatenka J, Kovalcikova J, Drahota Z, Kautzner J, Pirk J, Houstek J. Myocardial iron content and mitochondrial function in human heart failure: a direct tissue analysis. Eur J Heart Fail. 2017 Apr; 19 (4):522-530 Epub 2016 Sept 19
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Wohlfahrt P, Rokosny S, Melenovsky V, Borlaug BA, Pecenkova V, Balaz P. Reply to 'Cardiac remodeling after reduction of high-flow arteriovenous fistulas in end-stage renal disease: methodological issues'. Hypertens Res 2017 Apr; 40 (4):411 Epub 2016 Dec 01
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Borlaug BA, Carter RE, Melenovsky V, DeSimone CV, Gaba P, Killu A, Naksuk N, Lerman L, Asirvatham SJ. Percutaneous Pericardial Resection: A Novel Potential Treatment for Heart Failure With Preserved Ejection Fraction. Circ Heart Fail. 2017 Apr; 10 (4):e003612
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Killu AM, Naksuk N, Desimone CV, Gaba P, Suddendorf S, Powers J, Ladewig DJ, Lerman LO, Borlaug BA, Asirvatham SJ. Beating Heart Validation of Safety and Efficacy of a Percutaneous Pericardiotomy Tool. J Cardiovasc Electrophysiol. 2017 Mar; 28 (3):357-361 Epub 2016 Nov 17
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Fernandes-Silva MM, Shah AM, Hegde S, Goncalves A, Claggett B, Cheng S, Nadruz W, Kitzman DW, Konety SH, Matsushita K, Mosley T, Lam CS, Borlaug BA, Solomon SD. Race-Related Differences in Left Ventricular Structural and Functional Remodeling in Response to Increased Afterload: The ARIC Study. JACC Heart Fail. 2017 Mar; 5 (3):157-165 Epub 2016 Dec 21
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Obokata M, Kane GC, Reddy YN, Olson TP, Melenovsky V, Borlaug BA. Role of Diastolic Stress Testing in the Evaluation for Heart Failure With Preserved Ejection Fraction: A Simultaneous Invasive-Echocardiographic Study. Circulation. 2017 Feb 28; 135 (9):825-838 Epub 2016 Dec 30
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AbouEzzeddine OF, McKie PM, Dunlay SM, Stevens SR, Felker GM, Borlaug BA, Chen HH, Tracy RP, Braunwald E, Redfield MM. Suppression of Tumorigenicity 2 in Heart Failure With Preserved Ejection Fraction. J Am Heart Assoc. 2017 Feb 18; 6 (2)
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Wohlfahrt P, Melenovsky V, Redfield MM, Olson TP, Lin G, Abdelmoneim SS, Hametner B, Wassertheurer S, Borlaug BA. Aortic Waveform Analysis to Individualize Treatment in Heart Failure. Circ Heart Fail. 2017 Feb; 10 (2)
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Ghimire A, Andersen MJ, Burrowes LM, Bouwmeester JC, Grant AD, Belenkie I, Fine NM, Borlaug BA, Tyberg JV. The reservoir-wave approach to characterize pulmonary vascular-right ventricular interactions in humans. J Appl Physiol (1985). 2016 Dec 1; 121 (6):1348-1353 Epub 2016 Oct 20
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Borlaug BA, Kane GC, Melenovsky V, Olson TP. Abnormal right ventricular-pulmonary artery coupling with exercise in heart failure with preserved ejection fraction. Eur Heart J. 2016 Nov 14; 37 (43):3293-3302 Epub 2016 June 26
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Borlaug BA, Melenovsky V, Koepp KE. Inhaled Sodium Nitrite Improves Rest and Exercise Hemodynamics in Heart Failure With Preserved Ejection Fraction. Circ Res. 2016 Sep 16; 119 (7):880-6 Epub 2016 July 25
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Reddy YNV, Melenovsky V, Redfield MM, Nishimura RA, Borlaug BA. High-Output Heart Failure: A 15-Year Experience. J Am Coll Cardiol. 2016 Aug 2; 68 (5):473-482
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Wan SH, Stevens SR, Borlaug BA, Anstrom KJ, Deswal A, Felker GM, Givertz MM, Bart BA, Tang WH, Redfield MM, Chen HH. Differential Response to Low-Dose Dopamine or Low-Dose Nesiritide in Acute Heart Failure With Reduced or Preserved Ejection Fraction: Results From the ROSE AHF Trial (Renal Optimization Strategies Evaluation in Acute Heart Failure). Circ Heart Fail. 2016 Aug; 9 (8)
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Shah SJ, Kitzman DW, Borlaug BA, van Heerebeek L, Zile MR, Kass DA, Paulus WJ. Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction: A Multiorgan Roadmap. Circulation. 2016 Jul 5; 134 (1):73-90
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Olson TP, Johnson BD, Borlaug BA. Impaired Pulmonary Diffusion in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail. 2016 Jun; 4 (6):490-8
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Reddy YN, Borlaug BA. Heart Failure With Preserved Ejection Fraction. Curr Probl Cardiol. 2016 Apr; 41: (4)145-88.
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Hussain I, Mohammed SF, Forfia PR, Lewis GD, Borlaug BA, Gallup DS, Redfield MM. Impaired Right Ventricular-Pulmonary Arterial Coupling and Effect of Sildenafil in Heart Failure With Preserved Ejection Fraction: An Ancillary Analysis From the Phosphodiesterase-5 Inhibition to Improve Clinical Status And Exercise Capacity in Diastolic Heart Failure (RELAX) Trial. Circ Heart Fail. 2016 Apr; 9 (4):e002729
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Redfield MM, Anstrom KJ, Levine JA, Koepp GA, Borlaug BA, Chen HH, LeWinter MM, Joseph SM, Shah SJ, Semigran MJ, Felker GM, Cole RT, Reeves GR, Tedford RJ, Tang WH, McNulty SE, Velazquez EJ, Shah MR, Braunwald E, NHLBI Heart Failure Clinical Research Network. Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction. N Engl J Med. 2015 Dec 10; 373 (24):2314-24 Epub 2015 Nov 08
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Melenovsky V, Andersen MJ, Andress K, Reddy YN, Borlaug BA. Lung congestion in chronic heart failure: haemodynamic, clinical, and prognostic implications. Eur J Heart Fail. 2015 Nov; 17: (11)1161-71.
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Ye Z, Coutinho T, Pellikka PA, Villarraga HR, Borlaug BA, Kullo IJ. Associations of Alterations in Pulsatile Arterial Load With Left Ventricular Longitudinal Strain. Am J Hypertens. 2015 Nov; 28(11):1325-31. Epub 2015 Apr 03.
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Borlaug BA, Koepp KE, Melenovsky V. Sodium Nitrite Improves Exercise Hemodynamics and Ventricular Performance in Heart Failure With Preserved Ejection Fraction. J Am Coll Cardiol. 2015 Oct 13; 66: (15)1672-82.
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St John Sutton M, Cerkvenik J, Borlaug BA, Daubert C, Gold MR, Ghio S, Chirinos JA, Linde C, Ky B. Effects of Cardiac Resynchronization Therapy on Cardiac Remodeling and Contractile Function: Results From Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction (REVERSE). J Am Heart Assoc. 2015 Sep 11; 4 (9):e002054 Epub 2015 Sept 11
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Tsang MY, Choi JO, Borlaug BA, Greason KL, Cha SS, Nishimura RA, Oh JK. Low-Flow, Low-Gradient Severe Aortic Stenosis in the Setting of Constrictive Pericarditis: Clinical Characteristics, Echocardiographic Features, and Outcomes. Circ Cardiovasc Imaging. 2015 Jul; 8: (7)e002812.
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Andersen MJ, Hwang SJ, Kane GC, Melenovsky V, Olson TP, Fetterly K, Borlaug BA. Enhanced pulmonary vasodilator reserve and abnormal right ventricular: pulmonary artery coupling in heart failure with preserved ejection fraction. Circ Heart Fail. 2015 May; 8(3):542-50. Epub 2015 Apr 09.
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Borlaug BA, Lewis GD, McNulty SE, Semigran MJ, LeWinter M, Chen H, Lin G, Deswal A, Margulies KB, Redfield MM. Effects of sildenafil on ventricular and vascular function in heart failure with preserved ejection fraction. Circ Heart Fail. 2015 May; 8 (3):533-41 Epub 2015 Mar 17
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Melenovsky V, Hwang SJ, Redfield MM, Zakeri R, Lin G, Borlaug BA. Left atrial remodeling and function in advanced heart failure with preserved or reduced ejection fraction. Circ Heart Fail. 2015 Mar; 8(2):295-303. Epub 2015 Jan 15.
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AbouEzzeddine OF, Haines P, Stevens S, Nativi-Nicolau J, Felker GM, Borlaug BA, Chen HH, Tracy RP, Braunwald E, Redfield MM. Galectin-3 in heart failure with preserved ejection fraction. A RELAX trial substudy (Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure). JACC Heart Fail. 2015 Mar; 3 (3):245-52
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Zakeri R, Levine JA, Koepp GA, Borlaug BA, Chirinos JA, LeWinter M, VanBuren P, Davila-Roman VG, de Las Fuentes L, Khazanie P, Hernandez A, Anstrom K, Redfield MM. Nitrate's effect on activity tolerance in heart failure with preserved ejection fraction trial: rationale and design. Circ Heart Fail. 2015 Jan; 8 (1):221-8
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Fleg JL, Cooper LS, Borlaug BA, Haykowsky MJ, Kraus WE, Levine BD, Pfeffer MA, Pina IL, Poole DC, Reeves GR, Whellan DJ, Kitzman DW, National Heart, Lung, and Blood Institute Working Group. Exercise training as therapy for heart failure: current status and future directions. Circ Heart Fail. 2015 Jan; 8 (1):209-20
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Wohlfahrt P, Redfield MM, Melenovsky V, Lopez-Jimenez F, Rodeheffer RJ, Borlaug BA. Impact of chronic changes in arterial compliance and resistance on left ventricular ageing in humans. Eur J Heart Fail. 2015 Jan; 17 (1):27-34 Epub 2014 Oct 31
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Andersen MJ, Olson TP, Melenovsky V, Kane GC, Borlaug BA. Differential hemodynamic effects of exercise and volume expansion in people with and without heart failure. Circ Heart Fail. 2015 Jan; 8(1):41-8. Epub 2014 Oct 23.
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Melenovsky V, Hwang SJ, Lin G, Redfield MM, Borlaug BA. Right heart dysfunction in heart failure with preserved ejection fraction. Eur Heart J. 2014 Dec 21; 35 (48):3452-62 Epub 2014 May 29
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van Empel VP, Mariani J, Borlaug BA, Kaye DM. Impaired myocardial oxygen availability contributes to abnormal exercise hemodynamics in heart failure with preserved ejection fraction. J Am Heart Assoc. 2014 Dec 2; 3 (6):e001293 Epub 2014 Dec 02
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Andersen MJ, Ersboll M, Bro-Jeppesen J, Moller JE, Hassager C, Kober L, Borlaug BA, Goetze JP, Gustafsson F. Relationships between biomarkers and left ventricular filling pressures at rest and during exercise in patients after myocardial infarction. J Card Fail. 2014 Dec; 20 (12):959-67 Epub 2014 Oct 05
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Konecny T, Khanna AD, Novak J, Jama AA, Zawadowski GM, Orban M, Pressman G, Bukartyk J, Kara T, Cetta F Jr, Borlaug BA, Somers VK, Reeder GS. Interatrial pressure gradients during simulated obstructive sleep apnea: a catheter-based study. Catheter Cardiovasc Interv. 2014 Dec 1; 84 (7):1138-45 Epub 2014 Mar 11
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Borlaug BA. MY APPROACH to heart failure with preserved ejection fraction. Trends Cardiovasc Med. 2014 Nov; 24: (8)369-70.
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Andersen MJ, Nishimura RA, Borlaug BA. The hemodynamic basis of exercise intolerance in tricuspid regurgitation. Circ Heart Fail. 2014 Nov; 7(6):911-7. Epub 2014 Sep 04.
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Wohlfahrt P, Redfield MM, Lopez-Jimenez F, Melenovsky V, Kane GC, Rodeheffer RJ, Borlaug BA. Impact of general and central adiposity on ventricular-arterial aging in women and men. JACC Heart Fail. 2014 Oct; 2 (5):489-99 Epub 2014 Sept 03
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Borlaug BA. The pathophysiology of heart failure with preserved ejection fraction. Nat Rev Cardiol. 2014 Sep; 11 (9):507-15 Epub 2014 June 24
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Andersen MJ, Borlaug BA. Heart failure with preserved ejection fraction: current understandings and challenges. Curr Cardiol Rep. 2014 Jul; 16 (7):501
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Mohammed SF, Borlaug BA, McNulty S, Lewis GD, Lin G, Zakeri R, Semigran MJ, LeWinter M, Hernandez AF, Braunwald E, Redfield MM. Resting ventricular-vascular function and exercise capacity in heart failure with preserved ejection fraction: a RELAX trial ancillary study. Circ Heart Fail. 2014 Jul; 7 (4):580-9 Epub 2014 May 15
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Hwang SJ, Melenovsky V, Borlaug BA. Implications of coronary artery disease in heart failure with preserved ejection fraction. J Am Coll Cardiol. 2014 Jul 1; 63 (25 Pt A):2817-27 Epub 2014 Apr 23
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Andersen MJ, Borlaug BA. Invasive hemodynamic characterization of heart failure with preserved ejection fraction. Heart Fail Clin. 2014 Jul; 10(3):435-44.
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van Empel VP, Kaye DM, Borlaug BA. Effects of healthy aging on the cardiopulmonary hemodynamic response to exercise. Am J Cardiol. 2014 Jul 1; 114 (1):131-5 Epub 2014 Apr 18
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Miles JM, Rule AD, Borlaug BA. Use of metformin in diseases of aging. Curr Diab Rep. 2014 Jun; 14 (6):490
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Borlaug BA, Olson TP, Abdelmoneim SS, Melenovsky V, Sorrell VL, Noonan K, Lin G, Redfield MM. A randomized pilot study of aortic waveform guided therapy in chronic heart failure. J Am Heart Assoc. 2014 Mar 20; 3 (2):e000745
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Kaye D, Shah SJ, Borlaug BA, Gustafsson F, Komtebedde J, Kubo S, Magnin C, Maurer MS, Feldman T, Burkhoff D. Effects of an interatrial shunt on rest and exercise hemodynamics: results of a computer simulation in heart failure. J Card Fail. 2014 Mar; 20(3):212-21. Epub 2014 Jan 30.
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Zhang KW, French B, Khan AM, Plappert T, Fang JC, Sweitzer NK, Borlaug BA, Chirinos JA, John Sutton MS, Cappola TP, Ky B. Strain improves risk prediction beyond ejection fraction in chronic systolic heart failure. Journal of the American Heart Association. 2014; 3(1):e000550.
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Zakeri R, Borlaug BA, McNulty SE, Mohammed SF, Lewis GD, Semigran MJ, Deswal A, LeWinter M, Hernandez AF, Braunwald E, Redfield MM. Impact of atrial fibrillation on exercise capacity in heart failure with preserved ejection fraction: a RELAX trial ancillary study. Circ Heart Fail. 2014 Jan; 7 (1):123-30 Epub 2013 Oct 25
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Borlaug BA. Mechanisms of exercise intolerance in heart failure with preserved ejection fraction. Circ J. 2014; 78 (1):20-32 Epub 2013 Dec 03
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Chen HH, Anstrom KJ, Givertz MM, Stevenson LW, Semigran MJ, Goldsmith SR, Bart BA, Bull DA, Stehlik J, LeWinter MM, Konstam MA, Huggins GS, Rouleau JL, O'Meara E, Tang WH, Starling RC, Butler J, Deswal A, Felker GM, O'Connor CM, Bonita RE, Margulies KB, Cappola TP, Ofili EO, Mann DL, Davila-Roman VG, McNulty SE, Borlaug BA, Velazquez EJ, Lee KL, Shah MR, Hernandez AF, Braunwald E, Redfield MM, NHLBI Heart Failure Clinical Research Network. Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: the ROSE acute heart failure randomized trial. JAMA. 2013 Dec 18; 310 (23):2533-43
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Greene SJ, Gheorghiade M, Borlaug BA, Pieske B, Vaduganathan M, Burnett JC Jr, Roessig L, Stasch JP, Solomon SD, Paulus WJ, Butler J. The cGMP signaling pathway as a therapeutic target in heart failure with preserved ejection fraction. J Am Heart Assoc. 2013 Dec; 2(6):e000536. Epub 2013 Dec 11.
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Dong YX, Madhavan M, Wu JH, Oh JK, Mitsuru M, Powell BD, Dong K, Yang YZ, Hodge DO, Nishimura RA, Packer DL, Borlaug BA, Cha YM. Acute effects of atrial fibrillation on atrial and ventricular function: a simultaneous invasive-echocardiographic hemodynamic study. Int J Cardiol 2013 Nov 30; 169 (6):e114-9 Epub 2013 Oct 12
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Melenovsky V, Kotrc M, Borlaug BA, Marek T, Kovar J, Malek I, Kautzner J. Relationships between right ventricular function, body composition, and prognosis in advanced heart failure. J Am Coll Cardiol. 2013 Oct 29; 62 (18):1660-1670 Epub 2013 July 31
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Ky B, French B, May Khan A, Plappert T, Wang A, Chirinos JA, Fang JC, Sweitzer NK, Borlaug BA, Kass DA, St John Sutton M, Cappola TP. Ventricular-arterial coupling, remodeling, and prognosis in chronic heart failure. J Am Coll Cardiol. 2013 Sep 24; 62(13):1165-72. Epub 2013 Jun 13.
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Eleid MF, Nishimura RA, Sorajja P, Borlaug BA. Systemic hypertension in low-gradient severe aortic stenosis with preserved ejection fraction. Circulation. 2013 Sep 17; 128(12):1349-53. Epub 2013 Aug 16.
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Borlaug BA, Redfield MM, Melenovsky V, Kane GC, Karon BL, Jacobsen SJ, Rodeheffer RJ. Longitudinal changes in left ventricular stiffness: a community-based study. Circ Heart Fail. 2013 Sep 1; 6 (5):944-52 Epub 2013 June 28
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Miller WL, Grill DE, Borlaug BA. Clinical features, hemodynamics, and outcomes of pulmonary hypertension due to chronic heart failure with reduced ejection fraction: pulmonary hypertension and heart failure. JACC Heart Fail. 2013 Aug; 1 (4):290-299 Epub 2013 Aug 05
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Abudiab MM, Redfield MM, Melenovsky V, Olson TP, Kass DA, Johnson BD, Borlaug BA. Cardiac output response to exercise in relation to metabolic demand in heart failure with preserved ejection fraction. Eur J Heart Fail. 2013 Jul; 15 (7):776-85 Epub 2013 Feb 20
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Eleid MF, Nishimura RA, Borlaug BA, Sorajja P. Invasive measures of afterload in low gradient severe aortic stenosis with preserved ejection fraction. Circ Heart Fail. 2013 Jul; 6(4):703-10. Epub 2013 May 24.
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Benes J, Kotrc M, Borlaug BA, Lefflerova K, Jarolim P, Bendlova B, Jabor A, Kautzner J, Melenovsky V. Resting heart rate and heart rate reserve in advanced heart failure have distinct pathophysiologic correlates and prognostic impact: a prospective pilot study. JACC Heart Fail. 2013 Jun; 1(3):259-66. Epub 2013 Jun 03.
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Kalogeropoulos AP, Georgiopoulou VV, Borlaug BA, Gheorghiade M, Butler J. Left ventricular dysfunction with pulmonary hypertension: part 2: prognosis, noninvasive evaluation, treatment, and future research. Circ Heart Fail. 2013 May; 6(3):584-93.
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Redfield MM, Chen HH, Borlaug BA, Semigran MJ, Lee KL, Lewis G, LeWinter MM, Rouleau JL, Bull DA, Mann DL, Deswal A, Stevenson LW, Givertz MM, Ofili EO, O'Connor CM, Felker GM, Goldsmith SR, Bart BA, McNulty SE, Ibarra JC, Lin G, Oh JK, Patel MR, Kim RJ, Tracy RP, Velazquez EJ, Anstrom KJ, Hernandez AF, Mascette AM, Braunwald E, RELAX Trial. Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial. JAMA. 2013 Mar 27; 309 (12):1268-77
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Andersen MJ, Ersboll M, Axelsson A, Gustafsson F, Hassager C, Kober L, Borlaug BA, Boesgaard S, Skovgaard LT, Moller JE. Sildenafil and diastolic dysfunction after acute myocardial infarction in patients with preserved ejection fraction: the Sildenafil and Diastolic Dysfunction After Acute Myocardial Infarction (SIDAMI) trial. Circulation. 2013 Mar 19; 127(11):1200-8. Epub 2013 Feb 13.
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Georgiopoulou VV, Kalogeropoulos AP, Borlaug BA, Gheorghiade M, Butler J. Left ventricular dysfunction with pulmonary hypertension: Part 1: epidemiology, pathophysiology, and definitions. Circ Heart Fail. 2013 Mar; 6(2):344-54.
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Lam CS, Shah AM, Borlaug BA, Cheng S, Verma A, Izzo J, Oparil S, Aurigemma GP, Thomas JD, Pitt B, Zile MR, Solomon SD. Effect of antihypertensive therapy on ventricular-arterial mechanics, coupling, and efficiency. Eur Heart J. 2013 Mar; 34(9):676-83. Epub 2012 Sep 10.
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Coutinho T, Borlaug BA, Pellikka PA, Turner ST, Kullo IJ. Sex differences in arterial stiffness and ventricular-arterial interactions. J Am Coll Cardiol. 2013 Jan 08; 61(1):96-103. Epub 2012 Nov 01.
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Miller WL, Grill DE, Borlaug BA. Clinical Features, Hemodynamics and Natural History of Pulmonary Hypertension due to Heart Failure with reduced Ejection Fraction. JACC: Heart Failure. 2013 (in press).
Fujimoto N, Borlaug BA, Lewis GD, Hastings JL, Shafer KM, Bhella PS, Carrick-Ranson G, Levine BD. Hemodynamic responses to rapid saline loading: the impact of age, sex, and heart failure. Circulation. 2013 Jan 1; 127(1):55-62. Epub 2012 Nov 21.
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Borlaug BA. Invasive hemodynamic characterization of Heart Failure with preserved Ejection Fraction. Heart Failure Clinics. 2013 in press.
Borlaug BA. Heart Failure with preserved EF: curret understandings and challenges. Curr Cardiol Rep. 2013 in press.
Mohammed SF, Borlaug BA, Roger VL, Mirzoyev SA, Rodeheffer RJ, Chirinos JA, Redfield MM. Comorbidity and ventricular and vascular structure and function in heart failure with preserved ejection fraction: a community-based study. Circ Heart Fail. 2012 Nov; 5 (6):710-9 Epub 2012 Oct 17
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Bishu K, Deswal A, Chen HH, LeWinter MM, Lewis GD, Semigran MJ, Borlaug BA, McNulty S, Hernandez AF, Braunwald E, Redfield MM. Biomarkers in acutely decompensated heart failure with preserved or reduced ejection fraction. Am Heart J. 2012 Nov; 164 (5):763-770.e3 Epub 2012 Oct 16
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Redfield MM, Borlaug BA, Lewis GD, Mohammed SF, Semigran MJ, Lewinter MM, Deswal A, Hernandez AF, Lee KL, Braunwald E, Heart Failure Clinical Research Network. PhosphdiesteRasE-5 Inhibition to Improve CLinical Status and EXercise Capacity in Diastolic Heart Failure (RELAX) trial: rationale and design. Circ Heart Fail. 2012 Sep 1; 5(5):653-9.
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Fang JC, DeMarco T, Givertz MM, Borlaug BA, Lewis GD, Rame JE, Gomberg-Maitland M, Murali S, Frantz RP, McGlothlin D, Horn EM, Benza RL. World Health Organization Pulmonary Hypertension group 2: pulmonary hypertension due to left heart disease in the adult--a summary statement from the Pulmonary Hypertension Council of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant. 2012 Sep; 31(9):913-33.
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Munger TM, Dong YX, Masaki M, Oh JK, Mankad SV, Borlaug BA, Asirvatham SJ, Shen WK, Lee HC, Bielinski SJ, Hodge DO, Herges RM, Buescher TL, Wu JH, Ma C, Zhang Y, Chen PS, Packer DL, Cha YM. Electrophysiological and hemodynamic characteristics associated with obesity in patients with atrial fibrillation. J Am Coll Cardiol. 2012 Aug 28; 60(9):851-60. Epub 2012 Jun 20.
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Guazzi M, Borlaug BA. Pulmonary hypertension due to left heart disease. Circulation. 2012 Aug 21; 126(8):975-90.
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Andersen MJ, Ersboll M, Bro-Jeppesen J, Gustafsson F, Hassager C, Kober L, Borlaug BA, Boesgaard S, Kjaergaard J, Moller JE. Exercise hemodynamics in patients with and without diastolic dysfunction and preserved ejection fraction after myocardial infarction. Circ Heart Fail. 2012 Jul 1; 5(4):444-51. Epub 2012 Jun 15.
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Schwartzenberg S, Redfield MM, From AM, Sorajja P, Nishimura RA, Borlaug BA. Effects of vasodilation in heart failure with preserved or reduced ejection fraction implications of distinct pathophysiologies on response to therapy. J Am Coll Cardiol. 2012 Jan 31; 59 (5):442-51
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Tedford RJ, Hassoun PM, Mathai SC, Girgis RE, Russell SD, Thiemann DR, Cingolani OH, Mudd JO, Borlaug BA, Redfield MM, Lederer DJ, Kass DA. Pulmonary capillary wedge pressure augments right ventricular pulsatile loading. Circulation. 2012 Jan 17; 125(2):289-97. Epub 2011 Nov 30.
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Gharacholou SM, Scott CG, Borlaug BA, Kane GC, McCully RB, Oh JK, Pellikka PA. Relationship between diastolic function and heart rate recovery after symptom-limited exercise. J Card Fail. 2012 Jan; 18 (1):34-40 Epub 2011 Nov 09
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From AM, Lam CS, Pitta SR, Kumar PV, Balbissi KA, Booker JD, Singh IM, Sorajja P, Reeder GS, Borlaug BA. Bedside assessment of cardiac hemodynamics: the impact of noninvasive testing and examiner experience. Am J Med. 2011 Nov; 124(11):1051-7. Epub 2011 Sep 22.
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Scantlebury DC, Borlaug BA. Why are women more likely than men to develop heart failure with preserved ejection fraction? Curr Opin Cardiol. 2011 Nov; 26 (6):562-8
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From AM, Borlaug BA. Heart failure with preserved ejection fraction: pathophysiology and emerging therapies. Cardiovasc Ther. 2011 Aug; 29(4):e6-21. Epub 2010 Mar 29.
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Borlaug BA, Kass DA. Ventricular-vascular interaction in heart failure. Cardiol Clin. 2011 Aug; 29(3):447-59.
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Borlaug BA, Jaber WA, Ommen SR, Lam CS, Redfield MM, Nishimura RA. Diastolic relaxation and compliance reserve during dynamic exercise in heart failure with preserved ejection fraction. Heart. 2011 Jun; 97 (12):964-9 Epub 2011 Apr 08
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Borlaug BA, Redfield MM. Diastolic and systolic heart failure are distinct phenotypes within the heart failure spectrum. Circulation. 2011 May 10; 123 (18):2006-13; discussion 2014
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Borlaug BA, Kass DA. Invasive hemodynamic assessment in heart failure. Cardiol Clin. 2011 May; 29 (2):269-80
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Borlaug BA, Paulus WJ. Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment. Eur Heart J. 2011 Mar; 32 (6):670-9 Epub 2010 Dec 07
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Gharacholou SM, Maleszewski JJ, Borlaug BA, Cosio FG, Dearani JA, Kushwaha SS, Ammash NM. "Carcinoid-like" tricuspid valvulopathy associated with nephrogenic systemic fibrosis. Echocardiography. 2011 Mar; 28: (3)E46-9.
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Sobieszczyk P, Borlaug BA, Gornik HL, Knauft WD, Beckman JA. Glycyrrhetinic acid attenuates vascular smooth muscle vasodilatory function in healthy humans. Clin Sci (Lond). 2010 Nov; 119(10):437-42. Epub 2010 Aug 05.
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Park SJ, Nishimura RA, Borlaug BA, Sorajja P, Oh JK. The effect of loading alterations on left ventricular torsion: a simultaneous catheterization and two-dimensional speckle tracking echocardiographic study. Eur J Echocardiogr. 2010 Oct; 11(9):770-7. Epub 2010 May 18.
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Borlaug BA, Olson TP, Lam CS, Flood KS, Lerman A, Johnson BD, Redfield MM. Global cardiovascular reserve dysfunction in heart failure with preserved ejection fraction. J Am Coll Cardiol. 2010 Sep 7; 56 (11):845-54
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Borlaug BA, Nishimura RA, Sorajja P, Lam CS, Redfield MM. Exercise hemodynamics enhance diagnosis of early heart failure with preserved ejection fraction. Circ Heart Fail. 2010 Sep; 3 (5):588-95 Epub 2010 June 11
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Borlaug BA, Redfield MM. Heart Failure with Reduced the Preserved Ejection Fraction Represent Distinct Phenotypes in the Heart Failure Syndrome. Circulation. 2010 Jun 14 (in press).
Lam CS, Grewal J, Borlaug BA, Ommen SR, Kane GC, McCully RB, Pellikka PA. Size, shape, and stamina: the impact of left ventricular geometry on exercise capacity. Hypertension. 2010 May; 55 (5):1143-9 Epub 2010 Mar 09
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Borlaug BA. Sex, load and relaxation: Are women more susceptible to afterload-dependent diastolic dysfunciton? J Am Coll Cardiol. 2010 (n press).
Boilson BA, Schirger JA, Borlaug BA. Caveat medicus! Pulmonary hypertension in the elderly: a word of caution. Eur J Heart Fail. 2010 Jan; 12(1):89-93.
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Madhavan M, Borlaug BA, Lerman A, Rihal CS, Prasad A. Stress hormone and circulating biomarker profile of apical ballooning syndrome (Takotsubo cardiomyopathy): insights into the clinical significance of B-type natriuretic peptide and troponin levels. Heart. 2009 Sep; 95: (17)1436-41.
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Jaber WA, Sorajja P, Borlaug BA, Nishimura RA. Differentiation of tricuspid regurgitation from constrictive pericarditis: novel criteria for diagnosis in the cardiac catheterisation laboratory. Heart. 2009 Sep; 95(17):1449-54. Epub 2009 May 17.
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Borlaug BA, Lam CS, Roger VL, Rodeheffer RJ, Redfield MM. Contractility and ventricular systolic stiffening in hypertensive heart disease insights into the pathogenesis of heart failure with preserved ejection fraction. J Am Coll Cardiol. 2009 Jul 28; 54 (5):410-8
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Lam CS, Borlaug BA, Kane GC, Enders FT, Rodeheffer RJ, Redfield MM. Age-associated increases in pulmonary artery systolic pressure in the general population. Circulation. 2009 May 26; 119 (20):2663-70 Epub 2009 May 11
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Borlaug BA, Kass DA. Invasive hemodynamic assessment in heart failure. Heart Fail Clin. 2009 Apr; 5 (2):217-28
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Lam CS, Roger VL, Rodeheffer RJ, Borlaug BA, Enders FT, Redfield MM. Pulmonary hypertension in heart failure with preserved ejection fraction: a community-based study. J Am Coll Cardiol. 2009 Mar 31; 53 (13):1119-26
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Borlaug BA. Treatment of heart failure with preserved ejection fraction. Curr Treat Options Cardiovasc Med. 2009 Feb; 11 (1):79-87
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Sorajja P, Borlaug BA. Severe heart failure in the setting of relatively mild mitral stenosis: the role of invasive hemodynamic assessment. Catheter Cardiovasc Interv. 2008 Nov 1; 72(5):739-48.
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Borlaug BA, Kass DA. Ventricular-vascular interaction in heart failure. Heart Fail Clin. 2008 Jan; 4 (1):23-36
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Mudd JO, Borlaug BA, Johnston PV, Kral BG, Rouf R, Blumenthal RS, Kwiterovich PO Jr. Beyond low-density lipoprotein cholesterol: defining the role of low-density lipoprotein heterogeneity in coronary artery disease. J Am Coll Cardiol. 2007 Oct 30; 50(18):1735-41 Epub 2007 Oct 15.
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Borlaug BA, Melenovsky V, Redfield MM, Kessler K, Chang HJ, Abraham TP, Kass DA. Impact of arterial load and loading sequence on left ventricular tissue velocities in humans. J Am Coll Cardiol. 2007 Oct 16; 50: (16)1570-7.
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Melenovsky V, Borlaug BA, Fetics B, Kessler K, Shively L, Kass DA. Estimation of central pressure augmentation using automated radial artery tonometry.[see comment]. J Hypertens. 2007 Jul; 25(7):1403-9.
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Lam CS, Roger VL, Rodeheffer RJ, Bursi F, Borlaug BA, Ommen SR, Kass DA, Redfield MM. Cardiac structure and ventricular-vascular function in persons with heart failure and preserved ejection fraction from Olmsted County, Minnesota. Circulation. 2007 Apr 17; 115 (15):1982-90 Epub 2007 Apr 02
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Melenovsky V, Borlaug BA, Rosen B, Hay I, Ferruci L, Morell CH, Lakatta EG, Najjar SS, Kass DA. Cardiovascular features of heart failure with preserved ejection fraction versus nonfailing hypertensive left ventricular hypertrophy in the urban Baltimore community: the role of atrial remodeling/dysfunction. J Am Coll Cardiol. 2007 Jan 16; 49(2):198-207.
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Borlaug BA, Melenovsky V, Russell SD, Kessler K, Pacak K, Becker LC, Kass DA. Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction. Circulation. 2006 Nov 14; 114(20):2138-47. Epub 2006 Nov 06.
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Forfia PR, Fisher MR, Mathai SC, Housten-Harris T, Hemnes AR, Borlaug BA, Chamera E, Corretti MC, Champion HC, Abraham TP, Girgis RE, Hassoun PM. Tricuspid annular displacement predicts survival in pulmonary hypertension. Am J Respir Crit Care Med. 2006 Nov 1; 174(9):1034-41. Epub 2006 Aug 03.
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Borlaug BA, Kass DA. Mechanisms of diastolic dysfunction in heart failure. Trends Cardiovasc Med. 2006 Nov; 16(8):273-9.
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Borlaug BA, Melenovsky V, Marhin T, Fitzgerald P, Kass DA. Sildenafil inhibits beta-adrenergic-stimulated cardiac contractility in humans. Circulation. 2005 Oct 25; 112(17):2642-9.
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Redfield MM, Jacobsen SJ, Borlaug BA, Rodeheffer RJ, Kass DA. Age- and gender-related ventricular-vascular stiffening: a community-based study. Circulation. 2005 Oct 11; 112 (15):2254-62 Epub 2005 Oct 03
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Melenovsky V, Hay I, Fetics BJ, Borlaug BA, Kramer A, Pastore JM, Berger R, Kass DA. Functional impact of rate irregularity in patients with heart failure and atrial fibrillation receiving cardiac resynchronization therapy. Eur Heart J. 2005 Apr; 26(7):705-11.
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Barry A. Borlaug, M.D.

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