Publications

  1. Cui J, Mivalt F, Sladky V, Kim J, Richner TJ, Lundstrom BN, Van Gompel JJ, Wang HL, Miller KJ, Gregg N, Wu LJ, Denison T, Winter B, Brinkmann BH, Kremen V, Worrell GA. Acute to long-term characteristics of impedance recordings during neurostimulation in humans. J Neural Eng. 2024 Apr 3; 21 (2) Epub 2024 Apr 03
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  2. Ajani JA, D'Amico TA, Bentrem DJ, Chao J, Cooke D, Corvera C, Das P, Enzinger PC, Enzler T, Fanta P, Farjah F, Gerdes H, Gibson MK, Hochwald S, Hofstetter WL, Ilson DH, Keswani RN, Kim S, Kleinberg LR, Klempner SJ, Lacy J, Ly QP, Matkowskyj KA, McNamara M, Mulcahy MF, Outlaw D, Park H, Perry KA, Pimiento J, Poultsides GA, Reznik S, Roses RE, Strong VE, Su S, Wang HL, Wiesner G, Willett CG, Yakoub D, Yoon H, McMillian N, Pluchino LA. Gastric Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2022 Feb; 20 (2):167-192
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  3. Wang Y, Burghardt TP, Worrell GA, Wang HL. The frequency-dependent effect of electrical fields on the mobility of intracellular vesicles in astrocytes. Biochem Biophys Res Commun. 2021 Jan 1; 534:429-435 Epub 2020 Dec 03
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  4. Shen XM, Milone M, Wang HL, Banwell B, Selcen D, Sine SM, Engel AG. Slow-channel myasthenia due to novel mutation in M2 domain of AChR delta subunit. Ann Clin Transl Neurol. 2019 Oct; 6 (10):2066-2078 Epub 2019 Sept 27
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  5. Feng L, Murugan M, Bosco DB, Liu Y, Peng J, Worrell GA, Wang HL, Ta LE, Richardson JR, Shen Y, Wu LJ. Microglial proliferation and monocyte infiltration contribute to microgliosis following status epilepticus. Glia. 2019 Aug; 67 (8):1434-1448 Epub 2019 Apr 05
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  6. Wang HL, Cheng X, Sine SM. Intramembrane proton binding site linked to activation of bacterial pentameric ion channel. J Biol Chem. 2012 Feb 24; 287 (9):6482-9 Epub 2011 Nov 14
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  7. Fritsch S, Ivanov I, Wang H, Cheng X. Ion selectivity mechanism in a bacterial pentameric ligand-gated ion channel. Biophys J. 2011 Jan 19; 100(2):390-8.
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  8. Wang HL, Sine SM. Function of the acetylcholine receptor at the atomic scale. Journal Of Computational And Theoretical Nanoscience. 2010 Dec; 7(12):2538-42.
  9. Sine SM, Wang HL, Hansen S, Taylor P. On the origin of ion selectivity in the Cys-loop receptor family. J Mol Neurosci. 2010 Jan; 40 (1-2):70-6
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  10. Mukhtasimova N, Lee WY, Wang HL, Sine SM. Detection and trapping of intermediate states priming nicotinic receptor channel opening. Nature. 2009 May 21; 459 (7245):451-4 Epub 2009 Apr 01
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  11. Wang HL, Toghraee R, Papke D, Cheng XL, McCammon JA, Ravaioli U, Sine SM. Single-channel current through nicotinic receptor produced by closure of binding site C-loop. Biophys J. 2009 May 6; 96 (9):3582-90
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  12. Hansen SB, Wang HL, Taylor P, Sine SM. An ion selectivity filter in the extracellular domain of Cys-loop receptors reveals determinants for ion conductance. J Biol Chem. 2008 Dec 26; 283(52):36066-70. Epub 2008 Oct 21.
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  13. Lu T, Ye D, He T, Wang XL, Wang HL, Lee HC. Impaired Ca2+-dependent activation of large-conductance Ca2+-activated K+ channels in the coronary artery smooth muscle cells of Zucker Diabetic Fatty rats. Biophys J. 2008 Dec; 95 (11):5165-77 Epub 2008 Sept 12
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  14. Wang HL, Cheng X, Taylor P, McCammon JA, Sine SM. Control of cation permeation through the nicotinic receptor channel. PLoS Comput Biol. 2008 Feb; 4 (2):e41
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  15. Hansen SB, Wang H-L, Taylor P, Sine M. On the origin of ion conductance in pentameric Cys-loop receptors. J Bio Chem. 2008; 283(52):36066-70.
  16. Sine SM, Gao F, Lee WY, Mukhtasimova N, Wang HL, Engel AG. Recent structural and mechanistic insights into endplate acetylcholine receptors. Ann N Y Acad Sci. 2008; 1132:53-60
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  17. Cheng X-L, Ivanov I, Wang H-L, Sine SM, McCammon JA. Nanosecond Time Scale Conformational Dynamics of the Human alpha7 Nicotinic Acetylcholine Receptor. J. Biophysics. 2007 Jun 15.
  18. Cheng X, Wang H, Grant B, Sine SM, McCammon JA. Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors. PLoS Computational Biology. 2006; 2(9):1173-84.
  19. Henchman RH, Wang HL, Sine SM, Taylor P, McCammon JA. Ligand-induced conformational change in the alpha 7 nicotinic receptor ligand binding domain. Biophys J. 2005 Apr; 88(4):2564-76.
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  20. Ellison M, Gao F, Wang HL, Sine SM, Mclntosh JM, Olivera BM. Alpha-conotoxins ImI and ImII target distinct regions of the human alpha 7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes. Biochemistry. 2004 Dec 28; 43(51):16019-26.
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  21. Sine SM, Wang HL, Gao F. Toward atomic-scale understanding of ligand recognition in the muscle nicotinic receptor. Curr Med Chem. 2004 Mar; 11 (5):559-67
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  22. Bouzat C, Gumilar F, Spitzmaul G, Wang H-L, Rayes D, Hansen SB, Taylor P, Sine SM. Structural Network Coupling Agonist Binding to Channel Gating Revealed by ACh-binding Protein Linked to Ion Channel. Nature. 2004; 430:896-900.
  23. Henchman RH, Wang HL, Sine SM, Taylor P, McCammon JA. Asymmetric structural motions of the homomeric alpha 7 nicotinic receptor ligand binding domain revealed by molecular dynamics simulation. Biophys J. 2003 Nov 1; 85(5):3007-18.
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  24. Sine SM, Wang HL, Ohno K, Shen XM, Lee WY, Engel AG. Mechanistic diversity underlying fast channel congenital myasthenic syndromes. Ann N Y Acad Sci. 2003 Sep; 998:128-37
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  25. Wang HL, Gao F, Bren N, Sine SM. Curariform antagonists bind in different orientations to the nicotinic receptor ligand binding domain. J Biol Chem. 2003 Aug 22; 278 (34):32284-91 Epub 2003 June 10
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  26. Gao F, Bern N, Little A, Wang HL, Hansen SB, Talley TT, Taylor P, Sine SM. Curariform antagonists bind in different orientations to acetylcholine-binding protein. J Biol Chem. 2003 Jun 20; 278 (25):23020-6 Epub 2003 Apr 07
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  27. Sine SM, Shen XM, Wang HL, Ohno K, Lee WY, Tsujino A, Brengmann J, Bren N, Vajsar J, Engel AG. Naturally occurring mutations at the acetylcholine receptor binding site independently alter ACh binding and channel gating. J Gen Physiol. 2002 Oct; 120 (4):483-96
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  28. Sine SM, Wang HL, Bren N. Lysine scanning mutagenesis delineates structural model of the nicotinic receptor ligand binding domain. J Biol Chem. 2002 Aug 9; 277 (32):29210-23 Epub 2002 May 13
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  29. Ibanez-Tallon I, Miwa JM, Wang HL, Adams NC, Crabtree GW, Sine SM, Heintz N. Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1. Neuron. 2002 Mar 14; 33(6):893-903.
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  30. Wang HL, Ohno K, Milone M, Brengman JM, Evoli A, Batocchi AP, Middleton LT, Christodoulou K, Engel AG, Sine SM. Fundamental gating mechanism of nicotinic receptor channel revealed by mutation causing a congenital myasthenic syndrome. J Gen Physiol. 2000 Sep; 116 (3):449-62
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  31. Wang HL, Milone M, Ohno K, Shen XM, Tsujino A, Batocchi AP, Tonali P, Brengman J, Engel AG, Sine SM. Acetylcholine receptor M3 domain: stereochemical and volume contributions to channel gating. Nat Neurosci. 1999 Mar; 2 (3):226-33
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  32. Milone M, Wang HL, Ohno K, Prince R, Fukudome T, Shen XM, Brengman JM, Griggs RC, Sine SM, Engel AG. Mode switching kinetics produced by a naturally occurring mutation in the cytoplasmic loop of the human acetylcholine receptor epsilon subunit. Neuron. 1998 Mar; 20 (3):575-88
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  33. Engel AG, Ohno K, Wang HL, Milone M, Sine SM. Molecular basis of congenital myasthenic syndromes: mutations in the acetylcholine receptor. Neuroscientist. 1998; 4(3):185-94.
  34. Milone M, Wang HL, Ohno K, Fukudome T, Pruitt JN, Bren N, Sine SM, Engel AG. Slow-channel myasthenic syndrome caused by enhanced activation, desensitization, and agonist binding affinity attributable to mutation in the M2 domain of the acetylcholine receptor alpha subunit. J Neurosci. 1997 Aug 1; 17 (15):5651-65
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  35. Wang HL, Auerbach A, Bren N, Ohno K, Engel AG, Sine SM. Mutation in the M1 domain of the acetylcholine receptor alpha subunit decreases the rate of agonist dissociation. J Gen Physiol. 1997 Jun; 109 (6):757-66
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  36. Ohno K, Quiram PA, Milone M, Wang HL, Harper MC, Pruitt JN 2nd, Harper MC, Brengman JM, Pao L, Fischbeck KH, Crawford TO, Sine SM, Engel AG. Congenital myasthenic syndromes due to heteroallelic nonsense/missense mutations in the acetylcholine receptor epsilon subunit gene: identification and functional characterization of six new mutations. Hum Mol Genet. 1997 May; 6 (5):753-66
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  37. Engel AG, Ohno K, Milone M, Wang HL, Nakano S, Bouzat C, Pruitt JN 2nd, Hutchinson DO, Brengman JM, Bren N, Sieb JP, Sine SM. New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome. Hum Mol Genet. 1996 Sep; 5 (9):1217-27
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  38. Ohno K, Wang HL, Milone M, Bren N, Brengman JM, Nakano S, Quiram P, Pruitt JN, Sine SM, Engel AG. Congenital myasthenic syndrome caused by decreased agonist binding affinity due to a mutation in the acetylcholine receptor epsilon subunit. Neuron. 1996 Jul; 17 (1):157-70
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  39. Wang HL, Yang XL. [Differential effects of low calcium on signal transmission from rods and cones to horizontal cells in carp retina] Sheng Li Xue Bao. 1996 Apr; 48(2):113-24.
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  40. Wei JY, Wang HL, Yang XL. [Novel GABAc receptors]. Sheng Li Ke Xue Jin Zhan. 1995 Jan; 26(1):7-11.
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  41. Wei J-Y, Wang H-L, Yang X-L. Effects of acute hypoxia on response of horizontal cells and electroretinograms in carp retina in vivo. Chinese Science Bulletion. 1995.
  42. Wang HL, Wei JY, Yang XL. [Centrifugal fibers to the retina]. Sheng Li Ke Xue Jin Zhan. 1994 Jan; 25(1):22-6.
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  43. Wang H-L, Wie J-Y, Yang X-L. Suppression of carp retinal bipolar cells in darkness. Chinese Science Bulletin. 1994; 39(2):158-61.