Faculty

Sundeep Khosla, M.D.

Publications

Grossardt BR, Maradit Kremers H, Miller AR, Kasiske BL, Matas AJ, Khosla S, Kremers WK, Amer H, Kumar R. Persistent changes in calcium-regulating hormones and bone turnover markers in living kidney donors more than 20 years after donation. JBMR Plus. 2024 Jul; 8 (7):ziae067 Epub 2024 May 13
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Keaveny TM, Adams AL, Orwoll ES, Khosla S, Siris ES, McClung MR, Bouxsein ML, Fatemi S, Lee DC, Kopperdahl DL. Osteoporosis treatment prevents hip fracture similarly in both sexes: the FOCUS observational study. J Bone Miner Res. 2024 Jun 11 Epub 2024 June 11
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Yeo D, Zars Fisher EL, Khosla S, Farr JN, Westendorf JJ. Hdac3-deficiency increases senescence-associated distention of satellite DNA and telomere-associated foci in osteoprogenitor cells. J Bone Miner Res. 2024 Jun 6 Epub 2024 June 06
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Froemming MN, Khosla S, Farr JN. Marrow Adipocyte Senescence in the Pathogenesis of Bone Loss. Curr Osteoporos Rep. 2024 Jun 3 Epub 2024 June 03
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Suryadevara V, Hudgins AD, Rajesh A, Pappalardo A, Karpova A, Dey AK, Hertzel A, Agudelo A, Rocha A, Soygur B, Schilling B, Carver CM, Aguayo-Mazzucato C, Baker DJ, Bernlohr DA, Jurk D, Mangarova DB, Quardokus EM, Enninga EAL, Schmidt EL, Chen F, Duncan FE, Cambuli F, Kaur G, Kuchel GA, Lee G, Daldrup-Link HE, Martini H, Phatnani H, Al-Naggar IM, Rahman I, Nie J, Passos JF, Silverstein JC, Campisi J, Wang J, Iwasaki K, Barbosa K, Metis K, Nernekli K, Niedernhofer LJ, Ding L, Wang L, Adams LC, Ruiyang L, Doolittle ML, Teneche MG, Schafer MJ, Xu M, Hajipour M, Boroumand M, Basisty N, Sloan N, Slavov N, Kuksenko O, Robson P, Gomez PT, Vasilikos P, Adams PD, Carapeto P, Zhu Q, Ramasamy R, Perez-Lorenzo R, Fan R, Dong R, Montgomery RR, Shaikh S, Vickovic S, Yin S, Kang S, Suvakov S, Khosla S, Garovic VD, Menon V, Xu Y, Song Y, Suh Y, Dou Z, Neretti N. SenNet recommendations for detecting senescent cells in different tissues. Nat Rev Mol Cell Biol. 2024 Jun 3 Epub 2024 June 03
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Szulc P, Dufour AB, Hannan MT, Kiel DP, Chapurlat R, Sornay-Rendu E, Merle B, Boyd SK, Whittier DE, Hanley DA, Goltzman D, Wong AKO, Lespessailles E, Khosla S, Ferrari S, Biver E, Bouxsein ML, Samelson EJ. Fracture risk based on high-resolution peripheral quantitative computed tomography measures does not vary with age in older adults-the bone microarchitecture international consortium prospective cohort study. J Bone Miner Res. 2024 May 24; 39 (5):561-570
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Saul D, Doolittle ML, Rowsey JL, Froemming MN, Kosinsky RL, Vos SJ, Ruan M, LeBrasseur NK, Chandra A, Pignolo RJ, Passos JF, Farr JN, Monroe DG, Khosla S. Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair. J Clin Invest. 2024 May 16; 134 (12) [Epub ahead of print]
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Zhang X, Ng YE, Chini LCS, Heeren AA, White TA, Li H, Huang H, Doolittle ML, Khosla S, LeBrasseur NK. Senescent skeletal muscle fibroadipogenic progenitors recruit and promote M2 polarization of macrophages. Aging Cell. 2024 Mar; 23 (3):e14069 Epub 2023 Dec 19
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Vandenput L, Johansson H, McCloskey EV, Liu E, Schini M, Akesson KE, Anderson FA, Azagra R, Bager CL, Beaudart C, Bischoff-Ferrari HA, Biver E, Bruyere O, Cauley JA, Center JR, Chapurlat R, Christiansen C, Cooper C, Crandall CJ, Cummings SR, da Silva JAP, Dawson-Hughes B, Diez-Perez A, Dufour AB, Eisman JA, Elders PJM, Ferrari S, Fujita Y, Fujiwara S, Gluer CC, Goldshtein I, Goltzman D, Gudnason V, Hall J, Hans D, Hoff M, Hollick RJ, Huisman M, Iki M, Ish-Shalom S, Jones G, Karlsson MK, Khosla S, Kiel DP, Koh WP, Koromani F, Kotowicz MA, Kroger H, Kwok T, Lamy O, Langhammer A, Larijani B, Lippuner K, McGuigan FEA, Mellstrom D, Merlijn T, Nguyen TV, Nordstrom A, Nordstrom P, O'Neill TW, Obermayer-Pietsch B, Ohlsson C, Orwoll ES, Pasco JA, Rivadeneira F, Schott AM, Shiroma EJ, Siggeirsdottir K, Simonsick EM, Sornay-Rendu E, Sund R, Swart KMA, Szulc P, Tamaki J, Torgerson DJ, van Schoor NM, van Staa TP, Vila J, Wareham NJ, Wright NC, Yoshimura N, Zillikens M, Zwart M, Harvey NC, Lorentzon M, Leslie WD, Kanis JA. A meta-analysis of previous falls and subsequent fracture risk in cohort studies. Osteoporos Int. 2024 Mar; 35 (3):469-494 Epub 2024 Jan 17
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Aversa Z, White TA, Heeren AA, Hulshizer CA, Saul D, Zhang X, Molina AJA, Redman LM, Martin CK, Racette SB, Huffman KM, Bhapkar M, Khosla S, Das SK, Fielding RA, Atkinson EJ, LeBrasseur NK. Calorie restriction reduces biomarkers of cellular senescence in humans. Aging Cell. 2024 Feb; 23 (2):e14038 Epub 2023 Nov 14
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Yu GT, Monie DD, Khosla S, Tchkonia T, Kirkland JL, Wyles SP. Mapping cellular senescence networks in human diabetic foot ulcers. Geroscience. 2024 Feb; 46 (1):1071-1082 Epub 2023 June 29
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Englund DA, Jolliffe AM, Hanson GJ, Aversa Z, Zhang X, Jiang X, White TA, Zhang L, Monroe DG, Robbins PD, Niedernhofer LJ, Kamenecka TM, Khosla S, LeBrasseur NK. Senotherapeutic drug treatment ameliorates chemotherapy-induced cachexia. JCI Insight. 2024 Jan 23; 9 (2)
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Maradit Kremers H, Grossardt BR, Miller AR, Kasiske BL, Matas AJ, Khosla S, Kremers WK, Amer H, Kumar R. Fracture Risk Among Living Kidney Donors 25 Years After Donation. JAMA Netw Open. 2024 Jan 2; 7 (1):e2353005 Epub 2024 Jan 02
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Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF. Author Correction: Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature. 2024 Jan; 625(7995):E15.
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Prado M, Khosla S, Giambini H. Vertebral Fracture Risk Thresholds from Phantom-Less Quantitative Computed Tomography-Based Finite Element Modeling Correlate to Phantom-Based Outcomes. J Clin Densitom. 2024 Jan-Mar; 27 (1):101465 Epub 2023 Dec 19
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Kanis JA, Johansson H, McCloskey EV, Liu E, Akesson KE, Anderson FA, Azagra R, Bager CL, Beaudart C, Bischoff-Ferrari HA, Biver E, Bruyere O, Cauley JA, Center JR, Chapurlat R, Christiansen C, Cooper C, Crandall CJ, Cummings SR, da Silva JAP, Dawson-Hughes B, Diez-Perez A, Dufour AB, Eisman JA, Elders PJM, Ferrari S, Fujita Y, Fujiwara S, Gluer CC, Goldshtein I, Goltzman D, Gudnason V, Hall J, Hans D, Hoff M, Hollick RJ, Huisman M, Iki M, Ish-Shalom S, Jones G, Karlsson MK, Khosla S, Kiel DP, Koh WP, Koromani F, Kotowicz MA, Kroger H, Kwok T, Lamy O, Langhammer A, Larijani B, Lippuner K, Mellstrom D, Merlijn T, Nordstrom A, Nordstrom P, O'Neill TW, Obermayer-Pietsch B, Ohlsson C, Orwoll ES, Pasco JA, Rivadeneira F, Schott AM, Shiroma EJ, Siggeirsdottir K, Simonsick EM, Sornay-Rendu E, Sund R, Swart KMA, Szulc P, Tamaki J, Torgerson DJ, van Schoor NM, van Staa TP, Vila J, Wareham NJ, Wright NC, Yoshimura N, Zillikens MC, Zwart M, Vandenput L, Harvey NC, Lorentzon M, Leslie WD. Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX. Osteoporos Int. 2023 Dec; 34 (12):2027-2045 Epub 2023 Aug 11
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Pappert M, Khosla S, Doolittle M. Influences of Aged Bone Marrow Macrophages on Skeletal Health and Senescence. Curr Osteoporos Rep. 2023 Dec; 21 (6):771-778 Epub 2023 Sept 09
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Bartenschlager S, Cavallaro A, Pogarell T, Chaudry O, Uder M, Khosla S, Schett G, Engelke K. Opportunistic Screening With CT: Comparison of Phantomless BMD Calibration Methods. J Bone Miner Res. 2023 Nov; 38 (11):1689-1699 Epub 2023 Oct 01
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Doolittle ML, Eckhardt BA, Vos SJ, Grain S, Rowsey JL, Ruan M, Saul D, Farr JN, Weivoda MM, Khosla S, Monroe DG. Modest Effects of Osteoclast-Specific ERalpha Deletion after Skeletal Maturity. JBMR Plus. 2023 Oct; 7 (10):e10797 Epub 2023 July 13
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Doolittle ML, Khosla S, Saul D. Single-Cell Integration of BMD GWAS Results Prioritize Candidate Genes Influencing Age-Related Bone Loss. JBMR Plus. 2023 Oct; 7 (10):e10795 Epub 2023 July 07
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Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF. Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature. 2023 Oct; 622(7983):627-636. Epub 2023 Oct 11.
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Mousa J, Peterson MN, Crowson CS, Achenbach SJ, Atkinson EJ, Amin S, Khosla S, Davis JM 3rd, Myasoedova E. Validating the Fracture Risk Assessment Tool Score in a US Population-Based Study of Patients With Rheumatoid Arthritis. J Rheumatol. 2023 Oct; 50 (10):1279-1286 Epub 2023 July 01
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Howell R, Tang A, Allen J, Altaye M, Amin M, Bayan S, Belafsky P, Cervenka B, deSilva B, Dion G, Ekbom D, Friedman A, Fritz M, Giliberto JP, Guardiani E, Harmon J, Kasperbauer JL, Khosla S, Kim B, Kuhn M, Kwak P, Ma Y, Madden L, Matrka L, Mayerhoff R, Piraka C, Rosen C, Tabangin ME, Wahab SA, Wilson K, Wright SC, Young V, Yuen S, Postma GN. Killian Jamieson Diverticulum, the Great Mimicker: A Case Series and Contemporary Review. Laryngoscope. 2023 Sep; 133 (9):2110-2115 Epub 2022 Dec 01
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Whittier DE, Samelson EJ, Hannan MT, Burt LA, Hanley DA, Biver E, Szulc P, Sornay-Rendu E, Merle B, Chapurlat R, Lespessailles E, Wong AKO, Goltzman D, Khosla S, Ferrari S, Bouxsein ML, Kiel DP, Boyd SK. A Fracture Risk Assessment Tool for High Resolution Peripheral Quantitative Computed Tomography. J Bone Miner Res. 2023 Sep; 38 (9):1234-1244 Epub 2023 May 03
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Khosla S. Evidence in Humans for Bone as an Endocrine Organ Regulating Energy Metabolism. Curr Opin Endocr Metab Res. 2023 Aug; 31 Epub 2023 June 29
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Doolittle ML, Saul D, Kaur J, Rowsey JL, Vos SJ, Pavelko KD, Farr JN, Monroe DG, Khosla S. Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton. Nat Commun. 2023 Jul 31; 14 (1):4587 Epub 2023 July 31
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Espinoza SE, Khosla S, Baur JA, de Cabo R, Musi N. Drugs Targeting Mechanisms of Aging to Delay Age-Related Disease and Promote Healthspan: Proceedings of a National Institute on Aging Workshop. J Gerontol A Biol Sci Med Sci. 2023 Jun 16; 78 (Suppl 1):53-60
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Howell RJ, Ekbom D, Kasperbauer J, Tabangin M, Altaye M, Wahab S, Belafsky P, Allen J, Amin M, Bayan S, Cervenka B, deSilva B, Dion G, Friedman A, Fritz M, Giliberto JP, Guardiani E, Harmon J, Khosla S, Kim B, Kuhn M, Kwak P, Ma Y, Madden L, Matrka L, Mayerhoff R, Piraka C, Rosen C, Wilson K, Wright C, Young V, Yuen S, Postma G. Cricopharyngeus Muscle Dysfunction and Hypopharyngeal Diverticula (e.g., Zenker): A Multicenter Study. Laryngoscope. 2023 Jun; 133 (6):1349-1355 Epub 2022 Sept 14
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Kaur J, Saul D, Doolittle ML, Farr JN, Khosla S, Monroe DG. MicroRNA-19a-3p Decreases with Age in Mice and Humans and Inhibits Osteoblast Senescence. JBMR Plus. 2023 Jun; 7 (6):e10745 Epub 2023 Apr 18
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Samakkarnthai P, Saul D, Zhang L, Aversa Z, Doolittle ML, Sfeir JG, Kaur J, Atkinson EJ, Edwards JR, Russell GG, Pignolo RJ, Kirkland JL, Tchkonia T, Niedernhofer LJ, Monroe DG, Lebrasseur NK, Farr JN, Robbins PD, Khosla S. In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers. Aging (Albany NY). 2023 May 7; 15 (9):3331-3355 Epub 2023 May 07
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Farr JN, Saul D, Doolittle ML, Kaur J, Rowsey JL, Vos SJ, Froemming MN, Lagnado AB, Zhu Y, Weivoda M, Ikeno Y, Pignolo RJ, Niedernhofer LJ, Robbins PD, Jurk D, Passos JF, LeBrasseur NK, Tchkonia T, Kirkland JL, Monroe DG, Khosla S. Local senolysis in aged mice only partially replicates the benefits of systemic senolysis. J Clin Invest. 2023 Apr 17; 133 (8)
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Rufus-Membere P, Holloway-Kew KL, Diez-Perez A, Appelman-Dijkstra NM, Bouxsein ML, Eriksen EF, Farr JN, Khosla S, Kotowicz MA, Nogues X, Rubin M, Pasco JA. Reference Intervals for Bone Impact Microindentation in Healthy Adults: A Multi-Centre International Study. Calcif Tissue Int. 2023 Mar; 112 (3):338-349 Epub 2023 Feb 02
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Khosla S, Cheung J, Gurubhagavatula I, COVID-19 Task Force of the American Academy of Sleep Medicine. Sleep Assessment in Long COVID Clinics: A Necessary Tool for Effective Management. Neurol Clin Pract. 2023 Feb; 13 (1):e200079 Epub 2023 Jan 18
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Khosla S. Senescent cells, senolytics and tissue repair: the devil may be in the dosing. Nat Aging. 2023 Feb; 3 (2):139-141
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Khosla S, Wright NC, Elderkin AL, Kiel DP. Osteoporosis in the USA: prevention and unmet needs. Lancet Diabetes Endocrinol. 2023 Jan; 11 (1):19-20 Epub 2022 Nov 14
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Mousa J, Peterson MN, Crowson CS, Achenbach SJ, Atkinson EJ, Amin S, Khosla S, Davis JM III, Myasoedova E. Validating the fracture risk assessment tool score in a US population-based study of patients with rheumatoid arthritis. Journal of Rheumatology. 2023; 50 (10):1279-86
Zhao C, Keyak JH, Tang J, Kaneko TS, Khosla S, Amin S, Atkinson EJ, Zhao LJ, Serou MJ, Zhang C, Shen H, Deng HW, Zhou W. ST-V-Net: incorporating shape prior into convolutional neural networks for proximal femur segmentation. Complex Intell Systems. 2023; 9 (3):2747-2758 Epub 2021 June 16
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Barker AL, Morello R, Thao LTP, Seeman E, Ward SA, Sanders KM, Cumming RG, Pasco JA, Ebeling PR, Woods RL, Wolfe R, Khosla S, Hussain SM, Ronaldson K, Newman AB, Williamson JD, McNeil JJ. Daily Low-Dose Aspirin and Risk of Serious Falls and Fractures in Healthy Older People: A Substudy of the ASPREE Randomized Clinical Trial. JAMA Intern Med. 2022 Dec 1; 182 (12):1289-1297
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Saul D, Khosla S. Fracture Healing in the Setting of Endocrine Diseases, Aging, and Cellular Senescence. Endocr Rev. 2022 Nov 25; 43 (6):984-1002
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Wagner BM, Robinson JW, Prickett TCR, Espiner EA, Khosla S, Gaddy D, Suva LJ, Potter LR. Guanylyl Cyclase-B Dependent Bone Formation in Mice is Associated with Youth, Increased Osteoblasts, and Decreased Osteoclasts. Calcif Tissue Int. 2022 Nov; 111 (5):506-518 Epub 2022 Aug 10
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Vandenput L, Johansson H, McCloskey EV, Liu E, Akesson KE, Anderson FA, Azagra R, Bager CL, Beaudart C, Bischoff-Ferrari HA, Biver E, Bruyere O, Cauley JA, Center JR, Chapurlat R, Christiansen C, Cooper C, Crandall CJ, Cummings SR, da Silva JAP, Dawson-Hughes B, Diez-Perez A, Dufour AB, Eisman JA, Elders PJM, Ferrari S, Fujita Y, Fujiwara S, Gluer CC, Goldshtein I, Goltzman D, Gudnason V, Hall J, Hans D, Hoff M, Hollick RJ, Huisman M, Iki M, Ish-Shalom S, Jones G, Karlsson MK, Khosla S, Kiel DP, Koh WP, Koromani F, Kotowicz MA, Kroger H, Kwok T, Lamy O, Langhammer A, Larijani B, Lippuner K, Mellstrom D, Merlijn T, Nordstrom A, Nordstrom P, O'Neill TW, Obermayer-Pietsch B, Ohlsson C, Orwoll ES, Pasco JA, Rivadeneira F, Schei B, Schott AM, Shiroma EJ, Siggeirsdottir K, Simonsick EM, Sornay-Rendu E, Sund R, Swart KMA, Szulc P, Tamaki J, Torgerson DJ, van Schoor NM, van Staa TP, Vila J, Wareham NJ, Wright NC, Yoshimura N, Zillikens MC, Zwart M, Harvey NC, Lorentzon M, Leslie WD, Kanis JA. Update of the fracture risk prediction tool FRAX: a systematic review of potential cohorts and analysis plan. Osteoporos Int. 2022 Oct; 33 (10):2103-2136 Epub 2022 May 31
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Doolittle ML, Saul D, Kaur J, Rowsey JL, Eckhardt B, Vos S, Grain S, Kroupova K, Ruan M, Weivoda M, Oursler MJ, Farr JN, Monroe DG, Khosla S. Skeletal Effects of Inducible ERalpha Deletion in Osteocytes in Adult Mice. J Bone Miner Res. 2022 Sep; 37 (9):1750-1760 Epub 2022 July 22
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Saul D, Kosinsky RL, Atkinson EJ, Doolittle ML, Zhang X, LeBrasseur NK, Pignolo RJ, Robbins PD, Niedernhofer LJ, Ikeno Y, Jurk D, Passos JF, Hickson LJ, Xue A, Monroe DG, Tchkonia T, Kirkland JL, Farr JN, Khosla S. A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues. Nat Commun. 2022 Aug 16; 13 (1):4827
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Kaur J, Saul D, Doolittle ML, Rowsey JL, Vos SJ, Farr JN, Khosla S, Monroe DG. Identification of a suitable endogenous control miRNA in bone aging and senescence. Gene. 2022 Aug 15; 835:146642 Epub 2022 June 11
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Khosla S, Beam E, Berneking M, Cheung J, Epstein LJ, Meyer BJ, Ramar K, So JY, Sullivan SS, Wolfe LF, Gurubhagavatula I. The COVID-19 pandemic and sleep medicine: a look back and a look ahead. J Clin Sleep Med. 2022 Aug 1; 18 (8):2045-2050
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Kaur J, Khosla S, Farr JN. Effects of diabetes on osteocytes. Curr Opin Endocrinol Diabetes Obes. 2022 Aug 1; 29 (4):310-317 Epub 2022 June 24
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Zhang X, Habiballa L, Aversa Z, Ng YE, Sakamoto AE, Englund DA, Pearsall VM, White TA, Robinson MM, Rivas DA, Dasari S, Hruby AJ, Lagnado AB, Jachim SK, Granic A, Sayer AA, Jurk D, Lanza IR, Khosla S, Fielding RA, Nair KS, Schafer MJ, Passos JF, LeBrasseur NK. Characterization of cellular senescence in aging skeletal muscle. Nat Aging. 2022 Jul; 2(7):601-615. Epub 2022 Jul 15.
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Karsenty G, Khosla S. The crosstalk between bone remodeling and energy metabolism: A translational perspective. Cell Metab. 2022 Jun 7; 34 (6):805-817 Epub 2022 May 10
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Sfeir JG, Drake MT, Khosla S, Farr JN. Skeletal Aging. Mayo Clin Proc. 2022 Jun; 97 (6):1194-1208
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Chandra A, Lagnado AB, Farr JN, Doolittle M, Tchkonia T, Kirkland JL, LeBrasseur NK, Robbins PD, Niedernhofer LJ, Ikeno Y, Passos JF, Monroe DG, Pignolo RJ, Khosla S. Targeted clearance of p21- but not p16-positive senescent cells prevents radiation-induced osteoporosis and increased marrow adiposity. Aging Cell. 2022 May; 21 (5):e13602 Epub 2022 Apr 01
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Chandra A, Lagnado AB, Farr JN, Schleusner M, Monroe DG, Saul D, Passos JF, Khosla S, Pignolo RJ. Bone Marrow Adiposity in Models of Radiation- and Aging-Related Bone Loss Is Dependent on Cellular Senescence. J Bone Miner Res. 2022 May; 37 (5):997-1011 Epub 2022 Mar 29
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Zhu Y, Prata LGPL, Gerdes EOW, Netto JME, Pirtskhalava T, Giorgadze N, Tripathi U, Inman CL, Johnson KO, Xue A, Palmer AK, Chen T, Schaefer K, Justice JN, Nambiar AM, Musi N, Kritchevsky SB, Chen J, Khosla S, Jurk D, Schafer MJ, Tchkonia T, Kirkland JL. Orally-active, clinically-translatable senolytics restore alpha-Klotho in mice and humans. EBioMedicine. 2022 Mar; 77:103912 Epub 2022 Mar 13
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Whittier DE, Samelson EJ, Hannan MT, Burt LA, Hanley DA, Biver E, Szulc P, Sornay-Rendu E, Merle B, Chapurlat R, Lespessailles E, Wong AKO, Goltzman D, Khosla S, Ferrari S, Bouxsein ML, Kiel DP, Boyd SK. Bone Microarchitecture Phenotypes Identified in Older Adults Are Associated With Different Levels of Osteoporotic Fracture Risk. J Bone Miner Res. 2022 Mar; 37 (3):428-439 Epub 2022 Jan 14
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Khosla S, Farr JN, Monroe DG. Cellular senescence and the skeleton: pathophysiology and therapeutic implications. J Clin Invest. 2022 Feb 1; 132 (3)
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Eastell R, Vittinghoff E, Lui LY, McCulloch CE, Pavo I, Chines A, Khosla S, Cauley JA, Mitlak B, Bauer DC, Bouxsein M, Black DM. Validation of the Surrogate Threshold Effect for Change in Bone Mineral Density as a Surrogate Endpoint for Fracture Outcomes: The FNIH-ASBMR SABRE Project. J Bone Miner Res. 2022 Jan; 37 (1):29-35 Epub 2021 Sept 24
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Prado M, Khosla S, Chaput C, Giambini H. Opportunistic application of phantom-less calibration methods for fracture risk prediction using QCT/FEA. Eur Radiol. 2021 Dec; 31 (12):9428-9435 Epub 2021 May 28
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Verdoorn BP, Evans TK, Hanson GJ, Zhu Y, Langhi Prata LGP, Pignolo RJ, Atkinson EJ, Wissler-Gerdes EO, Kuchel GA, Mannick JB, Kritchevsky SB, Khosla S, Rizza SA, Walston JD, Musi N, Lipsitz LA, Kiel DP, Yung R, LeBrasseur NK, Singh RJ, McCarthy T, Puskarich MA, Niedernhofer LJ, Robbins PD, Sorenson M, Tchkonia T, Kirkland JL. Fisetin for COVID-19 in skilled nursing facilities: Senolytic trials in the COVID era. J Am Geriatr Soc. 2021 Nov; 69 (11):3023-3033 Epub 2021 Aug 20
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Schutte-Rodin S, Deak MC, Khosla S, Goldstein CA, Yurcheshen M, Chiang A, Gault D, Kern J, O'Hearn D, Ryals S, Verma N, Kirsch DB, Baron K, Holfinger S, Miller J, Patel R, Bhargava S, Ramar K. Evaluating consumer and clinical sleep technologies: an American Academy of Sleep Medicine update. J Clin Sleep Med. 2021 Nov 1; 17 (11):2275-2282
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Khosla S, Samakkarnthai P, Monroe DG, Farr JN. Update on the pathogenesis and treatment of skeletal fragility in type 2 diabetes mellitus. Nat Rev Endocrinol. 2021 Nov; 17 (11):685-697 Epub 2021 Sept 13
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Saul D, Monroe DG, Rowsey JL, Kosinsky RL, Vos SJ, Doolittle ML, Farr JN, Khosla S. Modulation of fracture healing by the transient accumulation of senescent cells. Elife. 2021 Oct 7; 10 Epub 2021 Oct 07
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Doolittle ML, Monroe DG, Farr JN, Khosla S. The role of senolytics in osteoporosis and other skeletal pathologies. Mech Ageing Dev. 2021 Oct; 199:111565 Epub 2021 Sept 06
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Aquino-Martinez R, Eckhardt BA, Rowsey JL, Fraser DG, Khosla S, Farr JN, Monroe DG. Senescent cells exacerbate chronic inflammation and contribute to periodontal disease progression in old mice. J Periodontol. 2021 Oct; 92 (10):1483-1495 Epub 2021 Jan 06
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Camell CD, Yousefzadeh MJ, Zhu Y, Prata LGPL, Huggins MA, Pierson M, Zhang L, O'Kelly RD, Pirtskhalava T, Xun P, Ejima K, Xue A, Tripathi U, Espindola-Netto JM, Giorgadze N, Atkinson EJ, Inman CL, Johnson KO, Cholensky SH, Carlson TW, LeBrasseur NK, Khosla S, O'Sullivan MG, Allison DB, Jameson SC, Meves A, Li M, Prakash YS, Chiarella SE, Hamilton SE, Tchkonia T, Niedernhofer LJ, Kirkland JL, Robbins PD. Senolytics reduce coronavirus-related mortality in old mice. Science. 2021 Jul 16; 373 (6552) Epub 2021 June 08
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Lagnado A, Leslie J, Ruchaud-Sparagano MH, Victorelli S, Hirsova P, Ogrodnik M, Collins AL, Vizioli MG, Habiballa L, Saretzki G, Evans SA, Salmonowicz H, Hruby A, Geh D, Pavelko KD, Dolan D, Reeves HL, Grellscheid S, Wilson CH, Pandanaboyana S, Doolittle M, von Zglinicki T, Oakley F, Gallage S, Wilson CL, Birch J, Carroll B, Chapman J, Heikenwalder M, Neretti N, Khosla S, Masuda CA, Tchkonia T, Kirkland JL, Jurk D, Mann DA, Passos JF. Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner. EMBO J. 2021 May 3; 40 (9):e106048 Epub 2021 Mar 25
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Sorimachi H, Obokata M, Takahashi N, Reddy YNV, Jain CC, Verbrugge FH, Koepp KE, Khosla S, Jensen MD, Borlaug BA. Pathophysiologic importance of visceral adipose tissue in women with heart failure and preserved ejection fraction. Eur Heart J. 2021 Apr 21; 42 (16):1595-1605
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Li D, Kaur RJ, Zhang CD, Ebbehoj A, Singh S, Atkinson EJ, Achenbach SJ, Rocca W, Khosla S, Bancos I. Risk of bone fractures after the diagnosis of adrenal adenomas: a population-based cohort study. Eur J Endocrinol. 2021 Apr; 184 (4):597-606
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Navin PJ, Moynagh MR, Atkinson EJ, Tirumanisetty P, LeBrasseur NK, Kumar A, Khosla S, Takahashi N. Establishment of normative biometric data for body composition based on computed tomography in a North American cohort. Clin Nutr. 2021 Apr; 40 (4):2435-2442 Epub 2020 Oct 29
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Sullivan S, Anastasi M, Beam E, Berneking M, Cheung J, Epstein LJ, Khosla S, Meyer B, Wolfe L, Gurubhagavatula I. Opportunities and unknowns in adapting pediatric sleep practices to a pandemic world. J Clin Sleep Med 2021 Mar 1; 17 (3):361-362
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Eastell R, Black DM, Lui LY, Chines A, Marin F, Khosla S, de Papp AE, Cauley JA, Mitlak B, McCulloch CE, Vittinghoff E, Bauer DC, Foundation for the National Institutes of Health (FNIH) Bone Quality Project. Treatment-Related Changes in Bone Turnover and Fracture Risk Reduction in Clinical Trials of Antiresorptive Drugs: Proportion of Treatment Effect Explained. J Bone Miner Res. 2021 Feb; 36 (2):236-243 Epub 2020 Oct 02
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Robbins PD, Jurk D, Khosla S, Kirkland JL, LeBrasseur NK, Miller JD, Passos JF, Pignolo RJ, Tchkonia T, Niedernhofer LJ. Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span. Annu Rev Pharmacol Toxicol. 2021 Jan 6; 61:779-803 Epub 2020 Sept 30
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Shiraishi K, Burghardt AJ, Osaki M, Khosla S, Carballido-Gamio J. Global and Spatial Compartmental Interrelationships of Bone Density, Microstructure, Geometry and Biomechanics in the Distal Radius in a Colles' Fracture Study Using HR-pQCT. Front Endocrinol (Lausanne). 2021; 12:568454 Epub 2021 May 26
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Crenshaw JR, Bernhardt KA, Atkinson EJ, Achenbach SJ, Khosla S, Amin S, Kaufman KR. Posterior single-stepping thresholds are prospectively related to falls in older women. Aging Clin Exp Res. 2020 Dec; 32 (12):2507-2515 Epub 2020 Feb 14
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Hong N, Lee DC, Khosla S, Keaveny TM, Rhee Y. Comparison of Vertebral and Femoral Strength Between White and Asian Adults Using Finite Element Analysis of Computed Tomography Scans. J Bone Miner Res. 2020 Dec; 35 (12):2345-2354 Epub 2020 Aug 31
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Ebbehoj A, Li D, Kaur RJ, Zhang C, Singh S, Li T, Atkinson E, Achenbach S, Khosla S, Arlt W, Young WF, Rocca WA, Bancos I. Epidemiology of adrenal tumours in Olmsted County, Minnesota, USA: a population-based cohort study. Lancet Diabetes Endocrinol. 2020 Nov; 8 (11):894-902
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Aquino-Martinez R, Khosla S, Farr JN, Monroe DG. Periodontal Disease and Senescent Cells: New Players for an Old Oral Health Problem? Int J Mol Sci. 2020 Oct 9; 21 (20) Epub 2020 Oct 09
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Samakkarnthai P, Sfeir JG, Atkinson EJ, Achenbach SJ, Wennberg PW, Dyck PJ, Tweed AJ, Volkman TL, Amin S, Farr JN, Vella A, Drake MT, Khosla S. Determinants of Bone Material Strength and Cortical Porosity in Patients with Type 2 Diabetes Mellitus. J Clin Endocrinol Metab. 2020 Oct 1; 105 (10):e3718-29
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Farr JN, Kaur J, Doolittle ML, Khosla S. Osteocyte Cellular Senescence. Curr Osteoporos Rep. 2020 Oct; 18 (5):559-567
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Napoli N, Elderkin AL, Kiel DP, Khosla S. Managing fragility fractures during the COVID-19 pandemic. Nat Rev Endocrinol. 2020 Sep; 16 (9):467-468
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Khalil R, Antonio L, Laurent MR, David K, Kim NR, Evenepoel P, Eisenhauer A, Heuser A, Cavalier E, Khosla S, Claessens F, Vanderschueren D, Decallonne B. Early effects of androgen deprivation on bone and mineral homeostasis in adult men: a prospective cohort study. Eur J Endocrinol. 2020 Aug; 183 (2):181-189
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Khosla S. Estrogen Versus FSH Effects on Bone Metabolism: Evidence From Interventional Human Studies. Endocrinology. 2020 Aug 1; 161 (8)
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Keyak JH, Kaneko TS, Khosla S, Amin S, Atkinson EJ, Lang TF, Sibonga JD. Hip load capacity and yield load in men and women of all ages. Bone. 2020 Aug; 137:115321 Epub 2020 Mar 14
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Black DM, Bauer DC, Vittinghoff E, Lui LY, Grauer A, Marin F, Khosla S, de Papp A, Mitlak B, Cauley JA, McCulloch CE, Eastell R, Bouxsein ML, Foundation for the National Institutes of Health Bone Quality Project. Treatment-related changes in bone mineral density as a surrogate biomarker for fracture risk reduction: meta-regression analyses of individual patient data from multiple randomised controlled trials. Lancet Diabetes Endocrinol. 2020 Aug; 8 (8):672-682
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Pignolo RJ, Passos JF, Khosla S, Tchkonia T, Kirkland JL. Reducing Senescent Cell Burden in Aging and Disease. Trends Mol Med. 2020 Jul; 26 (7):630-638 Epub 2020 Apr 17
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Keaveny TM, Clarke BL, Cosman F, Orwoll ES, Siris ES, Khosla S, Bouxsein ML. Biomechanical Computed Tomography analysis (BCT) for clinical assessment of osteoporosis. Osteoporos Int. 2020 Jun; 31 (6):1025-1048 Epub 2020 Apr 26
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Robinson JW, Blixt NC, Norton A, Mansky KC, Ye Z, Aparicio C, Wagner BM, Benton AM, Warren GL, Khosla S, Gaddy D, Suva LJ, Potter LR. Male mice with elevated C-type natriuretic peptide-dependent guanylyl cyclase-B activity have increased osteoblasts, bone mass and bone strength. Bone. 2020 Jun; 135:115320 Epub 2020 Mar 13
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Chandra A, Lagnado AB, Farr JN, Monroe DG, Park S, Hachfeld C, Tchkonia T, Kirkland JL, Khosla S, Passos JF, Pignolo RJ. Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy-Related Bone Loss. J Bone Miner Res. 2020 Jun; 35 (6):1119-1131 Epub 2020 Mar 05
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Eckhardt BA, Rowsey JL, Thicke BS, Fraser DG, O'Grady KL, Bondar OP, Hines JM, Singh RJ, Thoreson AR, Rakshit K, Lagnado AB, Passos JF, Vella A, Matveyenko AV, Khosla S, Monroe DG, Farr JN. Accelerated osteocyte senescence and skeletal fragility in mice with type 2 diabetes. JCI Insight. 2020 May 7; 5 (9) Epub 2020 May 07
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Conley RB, Adib G, Adler RA, Akesson KE, Alexander IM, Amenta KC, Blank RD, Brox WT, Carmody EE, Chapman-Novakofski K, Clarke BL, Cody KM, Cooper C, Crandall CJ, Dirschl DR, Eagen TJ, Elderkin AL, Fujita M, Greenspan SL, Halbout P, Hochberg MC, Javaid M, Jeray KJ, Kearns AE, King T, Koinis TF, Koontz JS, Kuzma M, Lindsey C, Lorentzon M, Lyritis GP, Michaud LB, Miciano A, Morin SN, Mujahid N, Napoli N, Olenginski TP, Puzas JE, Rizou S, Rosen CJ, Saag K, Thompson E, Tosi LL, Tracer H, Khosla S, Kiel DP. Secondary Fracture Prevention: Consensus Clinical Recommendations From a Multistakeholder Coalition. Orthop Nurs. 2020 May/Jun; 39 (3):145-161
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O'Grady KL, Khosla S, Farr JN, Bondar OP, Atkinson EJ, Achenbach SJ, Eckhardt BA, Thicke BS, Tweed AJ, Volkman TL, Drake MT, Hines JM, Singh RJ. Development and Application of Mass Spectroscopy Assays for Nepsilon-(1-Carboxymethyl)-L-Lysine and Pentosidine in Renal Failure and Diabetes. J Appl Lab Med. 2020 May 1; 5 (3):558-568
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Athimulam S, Delivanis D, Thomas M, Young WF, Khosla S, Drake MT, Bancos I. The Impact of Mild Autonomous Cortisol Secretion on Bone Turnover Markers. J Clin Endocrinol Metab. 2020 May 1; 105 (5):1469-77
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Khosla S, Farr JN, Tchkonia T, Kirkland JL. The role of cellular senescence in ageing and endocrine disease. Nat Rev Endocrinol. 2020 May; 16 (5):263-275 Epub 2020 Mar 11
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Khosla S. The microbiome adds to the complexity of parathyroid hormone action on bone. J Clin Invest. 2020 Apr 1; 130 (4):1615-1617
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Conley RB, Adib G, Adler RA, Akesson KE, Alexander IM, Amenta KC, Blank RD, Brox WT, Carmody EE, Chapman-Novakofski K, Clarke BL, Cody KM, Cooper C, Crandall CJ, Dirschl DR, Eagen TJ, Elderkin AL, Fujita M, Greenspan SL, Halbout P, Hochberg MC, Javaid M, Jeray KJ, Kearns AE, King T, Koinis TF, Koontz JS, Kuzma M, Lindsey C, Lorentzon M, Lyritis GP, Michaud LB, Miciano A, Morin SN, Mujahid N, Napoli N, Olenginski TP, Puzas JE, Rizou S, Rosen CJ, Saag K, Thompson E, Tosi LL, Tracer H, Khosla S, Kiel DP. Secondary Fracture Prevention: Consensus Clinical Recommendations from a Multistakeholder Coalition. J Orthop Trauma. 2020 Apr; 34 (4):e125-e141
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Aquino-Martinez R, Rowsey JL, Fraser DG, Eckhardt BA, Khosla S, Farr JN, Monroe DG. LPS-induced premature osteocyte senescence: Implications in inflammatory alveolar bone loss and periodontal disease pathogenesis. Bone. 2020 Mar; 132:115220 Epub 2020 Jan 02
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Wang Y, Zhao Y, Therneau TM, Atkinson EJ, Tafti AP, Zhang N, Amin S, Limper AH, Khosla S, Liu H. Unsupervised machine learning for the discovery of latent disease clusters and patient subgroups using electronic health records. J Biomed Inform. 2020 Feb; 102:103364 Epub 2019 Dec 28
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Hickson LJ, Langhi Prata LGP, Bobart SA, Evans TK, Giorgadze N, Hashmi SK, Herrmann SM, Jensen MD, Jia Q, Jordan KL, Kellogg TA, Khosla S, Koerber DM, Lagnado AB, Lawson DK, LeBrasseur NK, Lerman LO, McDonald KM, McKenzie TJ, Passos JF, Pignolo RJ, Pirtskhalava T, Saadiq IM, Schaefer KK, Textor SC, Victorelli SG, Volkman TL, Xue A, Wentworth MA, Wissler Gerdes EO, Allison DB, Dickinson SL, Ejima K, Atkinson EJ, Lenburg M, Zhu Y, Tchkonia T, Kirkland JL. Corrigendum to 'Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease' EBioMedicine 47 (2019) 446-456. EBioMedicine. 2020 Feb; 52:102595 Epub 2020 Jan 23
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Weivoda MM, Chew CK, Monroe DG, Farr JN, Atkinson EJ, Geske JR, Eckhardt B, Thicke B, Ruan M, Tweed AJ, McCready LK, Rizza RA, Matveyenko A, Kassem M, Andersen TL, Vella A, Drake MT, Clarke BL, Oursler MJ, Khosla S. Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism. Nat Commun. 2020 Jan 7; 11 (1):87 Epub 2020 Jan 07
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Conley RB, Adib G, Adler RA, Akesson KE, Alexander IM, Amenta KC, Blank RD, Brox WT, Carmody EE, Chapman-Novakofski K, Clarke BL, Cody KM, Cooper C, Crandall CJ, Dirschl DR, Eagen TJ, Elderkin AL, Fujita M, Greenspan SL, Halbout P, Hochberg MC, Javaid M, Jeray KJ, Kearns AE, King T, Koinis TF, Koontz JS, Kuzma M, Lindsey C, Lorentzon M, Lyritis GP, Michaud LB, Miciano A, Morin SN, Mujahid N, Napoli N, Olenginski TP, Puzas JE, Rizou S, Rosen CJ, Saag K, Thompson E, Tosi LL, Tracer H, Khosla S, Kiel DP. Secondary Fracture Prevention: Consensus Clinical Recommendations from a Multistakeholder Coalition. J Bone Miner Res. 2020 Jan; 35 (1):36-52 Epub 2019 Dec 01
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Khosla S, Davidge-Pitts C. Skeletal considerations in the medical treatment of transgender people. Lancet Diabetes Endocrinol. 2019 Dec; 7 (12):893-895 Epub 2019 Oct 31
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Khosla S. Personalising osteoporosis treatment for patients at high risk of fracture. Lancet Diabetes Endocrinol 2019 Oct; 7 (10):739-741 Epub 2019 Aug 22
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Leder BZ, Clarke BL, Shane E, Khosla S, Kiel DP. A Lot of Progress, With More to Be Done: A Response to NIH Pathways to Prevention Report "Research Gaps for Long-Term Drug Therapies for Osteoporotic Fracture Prevention". J Bone Miner Res. 2019 Sep; 34 (9):1549-1551 Epub 2019 July 25
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Hickson LJ, Langhi Prata LGP, Bobart SA, Evans TK, Giorgadze N, Hashmi SK, Herrmann SM, Jensen MD, Jia Q, Jordan KL, Kellogg TA, Khosla S, Koerber DM, Lagnado AB, Lawson DK, LeBrasseur NK, Lerman LO, McDonald KM, McKenzie TJ, Passos JF, Pignolo RJ, Pirtskhalava T, Saadiq IM, Schaefer KK, Textor SC, Victorelli SG, Volkman TL, Xue A, Wentworth MA, Wissler Gerdes EO, Zhu Y, Tchkonia T, Kirkland JL. Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease. EBioMedicine. 2019 Sep; 47:446-456 Epub 2019 Sept 18
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Farr JN, Rowsey JL, Eckhardt BA, Thicke BS, Fraser DG, Tchkonia T, Kirkland JL, Monroe DG, Khosla S. Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans. J Bone Miner Res. 2019 Aug; 34 (8):1407-1418 Epub 2019 June 21
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Farr JN, Khosla S. Cellular senescence in bone. Bone. 2019 Apr; 121:121-133 Epub 2019 Jan 16
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Zebaze R, Atkinson EJ, Peng Y, Bui M, Ghasem-Zadeh A, Khosla S, Seeman E. Increased Cortical Porosity and Reduced Trabecular Density Are Not Necessarily Synonymous With Bone Loss and Microstructural Deterioration. JBMR Plus. 2019 Apr; 3 (4):e10078 Epub 2018 Oct 04
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Al-Hijji M, Narula N, Go JL, Khosla S, Enriquez-Sarano M, Loeffler D, Lennon R, Lerman LO, Lerman A. Circulating Osteogenic Progenitor Cells in Mild, Moderate, and Severe Aortic Valve Stenosis. Mayo Clin Proc. 2019 Apr; 94 (4):652-659
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Anderson JR, Chung TDY, Clark L, Weis JA, Danielsen AJ, Khosla S, Gores GJ, Badley AD. Translation to Practice: Accelerating the Cycle of Innovation to Impact. Mayo Clin Proc. 2019 Mar; 94 (3):490-499 Epub 2019 Feb 07
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Jankowski CM, Wolfe P, Schmiege SJ, Nair KS, Khosla S, Jensen M, von Muhlen D, Laughlin GA, Kritz-Silverstein D, Bergstrom J, Bettencourt R, Weiss EP, Villareal DT, Kohrt WM. Sex-specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials. Clin Endocrinol (Oxf). 2019 Feb; 90 (2):293-300 Epub 2018 Dec 09
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Schulte FA, Christen P, Badilatti SD, Parkinson I, Khosla S, Goldhahn J, Muller R. Virtual supersampling as post-processing step preserves the trabecular bone morphometry in human peripheral quantitative computed tomography scans. PLoS One. 2019; 14 (2):e0212280 Epub 2019 Feb 13
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Samelson EJ, Broe KE, Xu H, Yang L, Boyd S, Biver E, Szulc P, Adachi J, Amin S, Atkinson E, Berger C, Burt L, Chapurlat R, Chevalley T, Ferrari S, Goltzman D, Hanley DA, Hannan MT, Khosla S, Liu CT, Lorentzon M, Mellstrom D, Merle B, Nethander M, Rizzoli R, Sornay-Rendu E, Van Rietbergen B, Sundh D, Wong AKO, Ohlsson C, Demissie S, Kiel DP, Bouxsein ML. Cortical and trabecular bone microarchitecture as an independent predictor of incident fracture risk in older women and men in the Bone Microarchitecture International Consortium (BoMIC): a prospective study. Lancet Diabetes Endocrinol. 2019 Jan; 7 (1):34-43 Epub 2018 Nov 28
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Lewiecki EM, Bilezikian JP, Giangregorio L, Greenspan SL, Khosla S, Kostenuik P, Krohn K, McClung MR, Miller PD, Pacifici R. Proceedings of the 2018 Santa Fe Bone Symposium: Advances in the Management of Osteoporosis. J Clin Densitom. 2019 Jan - Mar; 22 (1):1-19 Epub 2018 Sept 22
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Aquino-Martinez R, Farr JN, Weivoda MM, Negley BA, Onken JL, Thicke BS, Fulcer MM, Fraser DG, van Wijnen AJ, Khosla S, Monroe DG. miR-219a-5p Regulates Rorbeta During Osteoblast Differentiation and in Age-related Bone Loss. J Bone Miner Res. 2019 Jan; 34 (1):135-144 Epub 2018 Oct 15
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Sampson UKA, McGlynn EA, Perlin JB, Frisse ME, Arnold SB, Benz EJ Jr, Brennan T, Briss P, Beeuwkes Buntin MJ, Khosla S, King RG, Kuntz R, Leider H, Ling SM, Macrae J, Murray R, Thrailkill E, Wager C, Witchey D, Jacobson HR. Advancing the Science of Healthcare Service Delivery: The NHLBI Corporate Healthcare Leaders' Panel. Glob Heart. 2018 Dec; 13 (4):339-345 Epub 2018 Oct 06
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Khosla S, Drake MT, Volkman TL, Thicke BS, Achenbach SJ, Atkinson EJ, Joyner MJ, Rosen CJ, Monroe DG, Farr JN. Sympathetic beta1-adrenergic signaling contributes to regulation of human bone metabolism. J Clin Invest. 2018 Nov 1; 128 (11):4832-4842 Epub 2018 Oct 02
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Dragomir-Daescu D, Rossman TL, Rezaei A, Carlson KD, Kallmes DF, Skinner JA, Khosla S, Amin S. Factors associated with proximal femur fracture determined in a large cadaveric cohort. Bone. 2018 Nov; 116:196-202 Epub 2018 Aug 08
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Crenshaw JR, Bernhardt KA, Atkinson EJ, Khosla S, Kaufman KR, Amin S. The relationships between compensatory stepping thresholds and measures of gait, standing postural control, strength, and balance confidence in older women. Gait Posture. 2018 Sep; 65:74-80 Epub 2018 June 19
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Crenshaw JR, Bernhardt KA, Atkinson EJ, Khosla S, Kaufman KR, Amin S. The relationships between compensatory stepping thresholds and measures of gait, standing postural control, strength, and balance confidence in older women. Gait Posture. 2018 Sep; 65:74-80 Epub 2018 June 19
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Lee TH, Setty PT, Parthasarathy G, Bailey KR, Wood-Wentz CM, Fletcher JG, Takahashi N, Khosla S, Moynagh MR, Zinsmeister AR, Bharucha AE. Aging, Obesity, and the Incidence of Diverticulitis: A Population-Based Study. Mayo Clin Proc. 2018 Sep; 93 (9):1256-1265
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Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik MB, Hachfeld CM, Fraser DG, Onken JL, Johnson KO, Verzosa GC, Langhi LGP, Weigl M, Giorgadze N, LeBrasseur NK, Miller JD, Jurk D, Singh RJ, Allison DB, Ejima K, Hubbard GB, Ikeno Y, Cubro H, Garovic VD, Hou X, Weroha SJ, Robbins PD, Niedernhofer LJ, Khosla S, Tchkonia T, Kirkland JL. Senolytics improve physical function and increase lifespan in old age. Nat Med. 2018 Aug; 24 (8):1246-1256 Epub 2018 July 09
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Sfeir JG, Drake MT, Atkinson EJ, Achenbach SJ, Camp JJ, Tweed AJ, McCready LK, Yu L, Adkins MC, Amin S, Khosla S. Evaluation of cross-sectional and longitudinal changes in volumetric bone mineral density in postmenopausal women using single- versus dual-energy quantitative computed tomography. Bone. 2018 Jul; 112:145-152. Epub 2018 Apr 25.
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Adams AL, Fischer H, Kopperdahl DL, Lee DC, Black DM, Bouxsein ML, Fatemi S, Khosla S, Orwoll ES, Siris ES, Keaveny TM. Osteoporosis and Hip Fracture Risk From Routine Computed Tomography Scans: The Fracture, Osteoporosis, and CT Utilization Study (FOCUS). J Bone Miner Res. 2018 Jul; 33 (7):1291-1301 Epub 2018 Apr 17
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Oppenheimer-Velez ML, Giambini H, Rezaei A, Camp JJ, Khosla S, Lu L. The trabecular effect: A population-based longitudinal study on age and sex differences in bone mineral density and vertebral load bearing capacity. Clin Biomech (Bristol, Avon). 2018 Jun; 55:73-78 Epub 2018 Mar 27
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Drake MT, Fenske JS, Blocki FA, Zierold C, Appelman-Dijkstra N, Papapoulos S, Khosla S. Validation of a novel, rapid, high precision sclerostin assay not confounded by sclerostin fragments. Bone. 2018 Jun; 111:36-43 Epub 2018 Mar 14
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Khosla S, Deak MC, Gault D, Goldstein CA, Hwang D, Kwon Y, O'Hearn D, Schutte-Rodin S, Yurcheshen M, Rosen IM, Kirsch DB, Chervin RD, Carden KA, Ramar K, Aurora RN, Kristo DA, Malhotra RK, Martin JL, Olson EJ, Rosen CL, Rowley JA, American Academy of Sleep Medicine Board of Directors. Consumer Sleep Technology: An American Academy of Sleep Medicine Position Statement. J Clin Sleep Med. 2018 May 15; 14 (5):877-880
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Collins JD, Arch ES, Crenshaw JR, Bernhardt KA, Khosla S, Amin S, Kaufman KR. Net ankle quasi-stiffness is influenced by walking speed but not age for older adult women. Gait Posture. 2018 May; 62:311-316 Epub 2018 Mar 26
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Farr JN, Weivoda MM, Nicks KM, Fraser DG, Negley BA, Onken JL, Thicke BS, Ruan M, Liu H, Forrest D, Hawse JR, Khosla S, Monroe DG. Osteoprotection Through the Deletion of the Transcription Factor Rorbeta in Mice. J Bone Miner Res. 2018 Apr; 33 (4):720-731 Epub 2017 Dec 27
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Khosla S, Farr JN, Kirkland JL. Inhibiting Cellular Senescence: A New Therapeutic Paradigm for Age-Related Osteoporosis. J Clin Endocrinol Metab. 2018 Apr 1; 103 (4):1282-1290
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Bauer DC, Black DM, Bouxsein ML, Lui LY, Cauley JA, de Papp AE, Grauer A, Khosla S, McCulloch CE, Eastell R, Foundation for the National Institutes of Health (FNIH) Bone Quality Project. Treatment-Related Changes in Bone Turnover and Fracture Risk Reduction in Clinical Trials of Anti-Resorptive Drugs: A Meta-Regression. J Bone Miner Res. 2018 Apr; 33 (4):634-642 Epub 2018 Jan 10
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Khosla S, Monroe DG. Regulation of Bone Metabolism by Sex Steroids. Cold Spring Harb Perspect Med. 2018 Jan 2; 8 (1) Epub 2018 Jan 02
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Rianon NJ, Smith SM, Lee M, Pervin H, Musgrave P, Watt GP, Nader S, Khosla S, Ambrose CG, McCormick JB, Fisher-Hoch SP. Glycemic Control and Bone Turnover in Older Mexican Americans with Type 2 Diabetes. J Osteoporos. 2018; 2018:7153021 Epub 2018 May 13
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Khosla S. Bone diseases: Romosozumab - on track or derailed? Nat Rev Endocrinol 2017 Dec; 13 (12):697-698 Epub 2017 Oct 13
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Farr JN, Melton LJ 3rd, Achenbach SJ, Atkinson EJ, Khosla S, Amin S. Fracture Incidence and Characteristics in Young Adults Aged 18 to 49 Years: A Population-Based Study. J Bone Miner Res. 2017 Dec; 32 (12):2347-2354 Epub 2017 Oct 03
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Wright NC, Saag KG, Dawson-Hughes B, Khosla S, Siris ES. The impact of the new National Bone Health Alliance (NBHA) diagnostic criteria on the prevalence of osteoporosis in the United States: supplementary presentation. Osteoporos Int. 2017 Nov; 28 (11):3283-3284 Epub 2017 Sept 21
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Khosla S, Hofbauer LC. Osteoporosis treatment: recent developments and ongoing challenges. Lancet Diabetes Endocrinol. 2017 Nov; 5 (11):898-907 Epub 2017 July 07
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Crenshaw JR, Bernhardt KA, Achenbach SJ, Atkinson EJ, Khosla S, Kaufman KR, Amin S. The circumstances, orientations, and impact locations of falls in community-dwelling older women. Arch Gerontol Geriatr. 2017 Nov; 73:240-247 Epub 2017 July 21
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Farr JN, Xu M, Weivoda MM, Monroe DG, Fraser DG, Onken JL, Negley BA, Sfeir JG, Ogrodnik MB, Hachfeld CM, LeBrasseur NK, Drake MT, Pignolo RJ, Pirtskhalava T, Tchkonia T, Oursler MJ, Kirkland JL, Khosla S. Targeting cellular senescence prevents age-related bone loss in mice. Nat Med. 2017 Sep; 23 (9):1072-1079 Epub 2017 Aug 21
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Woodruff TK, Khosla S. New hope for symptom management during natural and iatrogenic menopause transitions. Biol Reprod. 2017 Aug 1; 97 (2):177-178
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Drake MT, Clarke BL, Oursler MJ, Khosla S. Cathepsin K Inhibitors for Osteoporosis: Biology, Potential Clinical Utility, and Lessons Learned. Endocr Rev. 2017 Aug 1; 38 (4):325-350
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Bonaretti S, Majumdar S, Lang TF, Khosla S, Burghardt AJ. The comparability of HR-pQCT bone measurements is improved by scanning anatomically standardized regions. Osteoporos Int. 2017 Jul; 28 (7):2115-2128 Epub 2017 Apr 08
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Carballido-Gamio J, Bonaretti S, Kazakia GJ, Khosla S, Majumdar S, Lang TF, Burghardt AJ. Statistical Parametric Mapping of HR-pQCT Images: A Tool for Population-Based Local Comparisons of Micro-Scale Bone Features. Ann Biomed Eng. 2017 Apr; 45 (4):949-962 Epub 2016 Nov 09
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Wright NC, Saag KG, Dawson-Hughes B, Khosla S, Siris ES. The impact of the new National Bone Health Alliance (NBHA) diagnostic criteria on the prevalence of osteoporosis in the USA. Osteoporos Int. 2017 Apr; 28 (4):1225-1232 Epub 2016 Dec 13
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Orwoll ES, Lapidus J, Wang PY, Vandenput L, Hoffman A, Fink HA, Laughlin GA, Nethander M, Ljunggren O, Kindmark A, Lorentzon M, Karlsson MK, Mellstrom D, Kwok A, Khosla S, Kwok T, Ohlsson C, Osteoporotic Fractures in Men (MrOS) Study Research Group. The Limited Clinical Utility of Testosterone, Estradiol, and Sex Hormone Binding Globulin Measurements in the Prediction of Fracture Risk and Bone Loss in Older Men. J Bone Miner Res. 2017 Mar; 32 (3):633-640 Epub 2016 Nov 14
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Khosla S, Cauley JA, Compston J, Kiel DP, Rosen C, Saag KG, Shane E. Addressing the Crisis in the Treatment of Osteoporosis: A Path Forward. J Bone Miner Res. 2017 Mar; 32 (3):424-430 Epub 2016 Dec 29
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Khosla S, Cauley JA, Compston J, Kiel DP, Rosen C, Saag KG, Shane E. Addressing the crisis in the treatment of osteoporosis: a path forward Journal Of Bone And Mineral Research. 2017 Mar; 32: (3)424-30.
Drake MT, Khosla S. Hormonal and systemic regulation of sclerostin. Bone. 2017 Mar; 96:8-17 Epub 2016 Dec 10
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Jafari A, Qanie D, Andersen TL, Zhang Y, Chen L, Postert B, Parsons S, Ditzel N, Khosla S, Johansen HT, Kjaersgaard-Andersen P, Delaisse JM, Abdallah BM, Hesselson D, Solberg R, Kassem M. Legumain Regulates Differentiation Fate of Human Bone Marrow Stromal Cells and Is Altered in Postmenopausal Osteoporosis. Stem Cell Reports. 2017 Feb 14; 8 (2):373-386 Epub 2017 Feb 02
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Finney Rutten LJ, Alexander A, Embi PJ, Flores G, Friedman C, Haller IV, Haug P, Jensen D, Khosla S, Runger G, Shah ND, Winden T, Roger VL. Patient-Centered Network of Learning Health Systems: Developing a resource for clinical translational research. J Clin Transl Sci. 2017 Feb; 1 (1):40-44 Epub 2017 Feb 02
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Yang SW, Hennessy RR, Khosla S, Lennon R, Loeffler D, Sun T, Liu Z, Park KH, Wang FL, Lerman LO, Lerman A. Circulating osteogenic endothelial progenitor cell counts: new biomarker for the severity of coronary artery disease. Int J Cardiol. 2017 Jan 15; 227:833-839 Epub 2016 Oct 27
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Barron ML, Rybchyn MS, Ramesh S, Mason RS, Fiona Bonar S, Stalley P, Khosla S, Hudson B, Arthur C, Kim E, Clifton-Bligh RJ, Clifton-Bligh PB. Clinical, cellular, microscopic, and ultrastructural studies of a case of fibrogenesis imperfecta ossium. Bone Res. 2017; 5:16057 Epub 2017 Mar 14
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Kirsh E, Zacharias SRC, de Alarcon A, Deliyski D, Tabangin M, Khosla S. Vertical Phase Difference and Glottal Efficiency in Musical Theater and Opera Singers. J Voice. 2017 Jan; 31 (1):130.e19-130.e25 Epub 2016 Jan 14
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Diez-Perez A, Bouxsein ML, Eriksen EF, Khosla S, Nyman JS, Papapoulos S, Tang SY. Technical note: Recommendations for a standard procedure to assess cortical bone at the tissue-level in vivo using impact microindentation. Bone Rep. 2016 Dec; 5:181-185 Epub 2016 July 26
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Farr JN, Fraser DG, Wang H, Jaehn K, Ogrodnik MB, Weivoda MM, Drake MT, Tchkonia T, LeBrasseur NK, Kirkland JL, Bonewald LF, Pignolo RJ, Monroe DG, Khosla S. Identification of Senescent Cells in the Bone Microenvironment. J Bone Miner Res. 2016 Nov; 31 (11):1920-1929 Epub 2016 Oct 24
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Khosla S, Shane E. A Crisis in the Treatment of Osteoporosis. J Bone Miner Res 2016 Aug; 31 (8):1485-7 Epub 2016 June 28
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Barker AL, McNeil JJ, Seeman E, Ward SA, Sanders KM, Khosla S, Cumming RG, Pasco JA, Bohensky MA, Ebeling PR, Woods RL, Lockery JE, Wolfe R, Talevski J, ASPREE Investigator Group. A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people: protocol for the ASPREE-Fracture substudy. Inj Prev. 2016 Aug; 22 (4):297-301 Epub 2015 May 21
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Sellmeyer DE, Civitelli R, Hofbauer LC, Khosla S, Lecka-Czernik B, Schwartz AV. Skeletal Metabolism, Fracture Risk, and Fracture Outcomes in Type 1 and Type 2 Diabetes. Diabetes. 2016 Jul; 65 (7):1757-66
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Schafer MJ, Atkinson EJ, Vanderboom PM, Kotajarvi B, White TA, Moore MM, Bruce CJ, Greason KL, Suri RM, Khosla S, Miller JD, Bergen HR 3rd, LeBrasseur NK. Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease. Cell Metab. 2016 Jun 14; 23 (6):1207-1215
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Boutroy S, Khosla S, Sornay-Rendu E, Zanchetta MB, McMahon DJ, Zhang CA, Chapurlat RD, Zanchetta J, Stein EM, Bogado C, Majumdar S, Burghardt AJ, Shane E. Microarchitecture and Peripheral BMD are Impaired in Postmenopausal White Women With Fracture Independently of Total Hip T-Score: An International Multicenter Study. J Bone Miner Res. 2016 Jun; 31 (6):1158-66
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Nicks KM, Fujita K, Fraser D, McGregor U, Drake MT, McGee-Lawrence ME, Westendorf JJ, Monroe DG, Khosla S. Deletion of Estrogen Receptor Beta in Osteoprogenitor Cells Increases Trabecular but Not Cortical Bone Mass in Female Mice. J Bone Miner Res. 2016 Mar; 31 (3):606-14 Epub 2015 Oct 13
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Christen P, Schulte FA, Zwahlen A, van Rietbergen B, Boutroy S, Melton LJ 3rd, Amin S, Khosla S, Goldhahn J, Muller R. Voxel size dependency, reproducibility and sensitivity of an in vivo bone loading estimation algorithm. J R Soc Interface. 2016 Jan; 13 (114):20150991
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McGee-Lawrence ME, Carpio LR, Schulze RJ, Pierce JL, McNiven MA, Farr JN, Khosla S, Oursler MJ, Westendorf JJ. Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells. J Bone Miner Res. 2016 Jan; 31 (1):116-28 Epub 2015 Aug 20
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Farr JN, Khosla S. Determinants of bone strength and quality in diabetes mellitus in humans. Bone. 2016 Jan; 82:28-34 Epub 2015 July 26
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Weivoda MM, Ruan M, Pederson L, Hachfeld C, Davey RA, Zajac JD, Westendorf JJ, Khosla S, Oursler MJ. Osteoclast TGF-beta Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation. J Bone Miner Res. 2016 Jan; 31 (1):76-85 Epub 2015 Aug 06
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Fidler JL, Murthy NS, Khosla S, Clarke BL, Bruining DH, Kopperdahl DL, Lee DC, Keaveny TM. Comprehensive Assessment of Osteoporosis and Bone Fragility with CT Colonography. Radiology. 2016 Jan; 278 (1):172-80 Epub 2015 July 22
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Weivoda MM, Ruan M, Hachfeld CM, Pederson L, Howe A, Davey RA, Zajac JD, Kobayashi Y, Williams BO, Westendorf JJ, Khosla S, Oursler MJ. Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways. J Bone Miner Res. 2016 Jan; 31 (1):65-75 Epub 2015 Aug 19
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Farr JN, Khosla S. Skeletal changes through the lifespan--from growth to senescence. Nat Rev Endocrinol. 2015 Sep; 11 (9):513-21 Epub 2015 June 02
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Carballido-Gamio J, Bonaretti S, Saeed I, Harnish R, Recker R, Burghardt AJ, Keyak JH, Harris T, Khosla S, Lang TF. Automatic multi-parametric quantification of the proximal femur with quantitative computed tomography. Quant Imaging Med Surg. 2015 Aug; 5 (4):552-68
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Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, O'Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, LeBrasseur NK, Wren JD, Farr JN, Khosla S, Stout MB, McGowan SJ, Fuhrmann-Stroissnigg H, Gurkar AU, Zhao J, Colangelo D, Dorronsoro A, Ling YY, Barghouthy AS, Navarro DC, Sano T, Robbins PD, Niedernhofer LJ, Kirkland JL. The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell. 2015 Aug; 14 (4):644-58 Epub 2015 Apr 22
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Roforth MM, Farr JN, Fujita K, McCready LK, Atkinson EJ, Therneau TM, Cunningham JM, Drake MT, Monroe DG, Khosla S. Global transcriptional profiling using RNA sequencing and DNA methylation patterns in highly enriched mesenchymal cells from young versus elderly women. Bone. 2015 Jul; 76:49-57 Epub 2015 Mar 27
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Engelke K, Lang T, Khosla S, Qin L, Zysset P, Leslie WD, Shepherd JA, Shousboe JT. Clinical Use of Quantitative Computed Tomography-Based Advanced Techniques in the Management of Osteoporosis in Adults: the 2015 ISCD Official Positions-Part III. J Clin Densitom. 2015 Jul-Sep; 18 (3):393-407
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Zysset P, Qin L, Lang T, Khosla S, Leslie WD, Shepherd JA, Schousboe JT, Engelke K. Clinical Use of Quantitative Computed Tomography-Based Finite Element Analysis of the Hip and Spine in the Management of Osteoporosis in Adults: the 2015 ISCD Official Positions-Part II. J Clin Densitom. 2015 Jul-Sep; 18: (3)359-92.
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Engelke K, Lang T, Khosla S, Qin L, Zysset P, Leslie WD, Shepherd JA, Schousboe JT. Clinical Use of Quantitative Computed Tomography (QCT) of the Hip in the Management of Osteoporosis in Adults: the 2015 ISCD Official Positions-Part I. J Clin Densitom. 2015 Jul-Sep; 18 (3):338-58
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Binkley N, Lappe J, Singh RJ, Khosla S, Krueger D, Drezner MK, Blank RD. Can vitamin D metabolite measurements facilitate a "treat-to-target" paradigm to guide vitamin D supplementation? Osteoporos Int. 2015 May; 26(5):1655-60.
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Collin J, Gossl M, Matsuo Y, Cilluffo RR, Flammer AJ, Loeffler D, Lennon RJ, Simari RD, Spoon DB, Erbel R, Lerman LO, Khosla S, Lerman A. Osteogenic monocytes within the coronary circulation and their association with plaque vulnerability in patients with early atherosclerosis. Int J Cardiol. 2015 Feb 15; 181:57-64 Epub 2014 Nov 26
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Peris P, Roforth MM, Nicks KM, Fraser D, Fujita K, Jilka RL, Khosla S, McGregor U. Ability of circulating human hematopoietic lineage negative cells to support hematopoiesis. J Cell Biochem. 2015 Jan; 116 (1):58-66
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Farr JN, Roforth MM, Fujita K, Nicks KM, Cunningham JM, Atkinson EJ, Therneau TM, McCready LK, Peterson JM, Drake MT, Monroe DG, Khosla S. Effects of Age and Estrogen on Skeletal Gene Expression in Humans as Assessed by RNA Sequencing. PLoS One. 2015; 10 (9):e0138347 Epub 2015 Sept 24
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Bergen HR 3rd, Farr JN, Vanderboom PM, Atkinson EJ, White TA, Singh RJ, Khosla S, LeBrasseur NK. Myostatin as a mediator of sarcopenia versus homeostatic regulator of muscle mass: insights using a new mass spectrometry-based assay. Skelet Muscle. 2015; 5:21. Epub 2015 Jul 15.
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Farr JN, Amin S, LeBrasseur NK, Atkinson EJ, Achenbach SJ, McCready LK, Joseph Melton L 3rd, Khosla S. Body composition during childhood and adolescence: relations to bone strength and microstructure. J Clin Endocrinol Metab. 2014 Dec; 99 (12):4641-8
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Fujita K, Xing Q, Khosla S, Monroe DG. Mutual enhancement of differentiation of osteoblasts and osteocytes occurs through direct cell-cell contact. J Cell Biochem. 2014 Nov; 115 (11):2039-44
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Liu M, Goss PE, Ingle JN, Kubo M, Furukawa Y, Batzler A, Jenkins GD, Carlson EE, Nakamura Y, Schaid DJ, Chapman JA, Shepherd LE, Ellis MJ, Khosla S, Wang L, Weinshilboum RM. Aromatase inhibitor-associated bone fractures: a case-cohort GWAS and functional genomics. Mol Endocrinol. 2014 Oct; 28 (10):1740-51 Epub 2014 Aug 22
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Farr JN, Khosla S, Achenbach SJ, Atkinson EJ, Kirmani S, McCready LK, Melton LJ 3rd, Amin S. Diminished bone strength is observed in adult women and men who sustained a mild trauma distal forearm fracture during childhood. J Bone Miner Res. 2014 Oct; 29 (10):2193-202
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Egorov V, Tatarinov A, Sarvazyan N, Wood R, Magidenko L, Amin S, Khosla S, Ruh RJ, Ruh JM, Sarvazyan A. Osteoporosis detection in postmenopausal women using axial transmission multi-frequency bone ultrasonometer: clinical findings. Ultrasonics. 2014 Jul; 54 (5):1170-7 Epub 2013 Sept 10
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Siris E, Adler R, Bilezikian J, Bolognese M, Dawson-Hughes B, Favus M, Harris S, Jan de Beur S, Khosla S, Lane N, Lindsay R, Nana A, Orwoll E, Saag K, Silverman S, Watts N. The clinical diagnosis of osteoporosis: a position statement from the national bone health alliance working group. Osteoporos Int. 2014 May; 25(5):1439-43.
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Goss PE, Hershman DL, Cheung AM, Ingle JN, Khosla S, Stearns V, Chalchal H, Rowland K, Muss HB, Linden HM, Scher J, Pritchard KI, Elliott CR, Badovinac-Crnjevic T, St Louis J, Chapman JA, Shepherd LE. Effects of adjuvant exemestane versus anastrozole on bone mineral density for women with early breast cancer (MA.27B): a companion analysis of a randomised controlled trial. Lancet Oncol. 2014 Apr; 15 (4):474-82 Epub 2014 Mar 11
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Farr JN, Drake MT, Amin S, Melton LJ 3rd, McCready LK, Khosla S. In vivo assessment of bone quality in postmenopausal women with type 2 diabetes. J Bone Miner Res. 2014 Apr; 29 (4):787-95
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Weber NK, Fidler JL, Keaveny TM, Clarke BL, Khosla S, Fletcher JG, Lee DC, Pardi DS, Loftus EV Jr, Kane SV, Barlow JM, Murthy NS, Becker BD, Bruining DH. Validation of a CT-derived method for osteoporosis screening in IBD patients undergoing contrast-enhanced CT enterography. Am J Gastroenterol. 2014 Mar; 109 (3):401-8 Epub 2014 Jan 21
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Fujita K, Roforth MM, Atkinson EJ, Peterson JM, Drake MT, McCready LK, Farr JN, Monroe DG, Khosla S. Isolation and characterization of human osteoblasts from needle biopsies without in vitro culture. Osteoporos Int. 2014 Mar; 25 (3):887-95 Epub 2013 Oct 11
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Farr JN, Amin S, Melton LJ 3rd, Kirmani S, McCready LK, Atkinson EJ, Muller R, Khosla S. Bone strength and structural deficits in children and adolescents with a distal forearm fracture resulting from mild trauma. J Bone Miner Res. 2014 Mar; 29 (3):590-9
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Amin S, Achenbach SJ, Atkinson EJ, Khosla S, Melton LJ 3rd. Trends in fracture incidence: a population-based study over 20 years. J Bone Miner Res. 2014 Mar; 29 (3):581-9
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Roforth MM, Fujita K, McGregor UI, Kirmani S, McCready LK, Peterson JM, Drake MT, Monroe DG, Khosla S. Effects of age on bone mRNA levels of sclerostin and other genes relevant to bone metabolism in humans. Bone. 2014 Feb; 59:1-6 Epub 2013 Oct 29
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Bonaretti S, Carpenter RD, Saeed I, Burghardt AJ, Yu L, Bruesewitz M, Khosla S, Lang T. Novel anthropomorphic hip phantom corrects systemic interscanner differences in proximal femoral vBMD. Phys Med Biol. 2014; 59(24):7819-34.
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Prasad M, Reriani M, Khosla S, Gossl M, Lennon R, Gulati R, Prasad A, Lerman LO, Lerman A. Coronary microvascular endothelial dysfunction is an independent predictor of development of osteoporosis in postmenopausal women. Vasc Health Risk Manag. 2014; 10:533-8 Epub 2014 Aug 26
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Roforth MM, Atkinson EJ, Levin ER, Khosla S, Monroe DG. Dissection of estrogen receptor alpha signaling pathways in osteoblasts using RNA-sequencing. PLoS One. 2014; 9 (4):e95987 Epub 2014 Apr 28
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Bala Y, Zebaze R, Ghasem-Zadeh A, Atkinson EJ, Iuliano S, Peterson JM, Amin S, Bjornerem A, Melton LJ III, Johansson H, Kanis JA, Khosla S, Seeman E. Cortical porosity identifies women with osteopenia at increased risk for forearm fractures. J Bone Miner Res. 2014; 29(6):1356-62.
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Fujita K, Roforth MM, Demaray S, McGregor U, Kirmani S, McCready LK, Peterson JM, Drake MT, Monroe DG, Khosla S. Effects of estrogen on bone mRNA levels of sclerostin and other genes relevant to bone metabolism in postmenopausal women. J Clin Endocrinol Metab. 2014 Jan; 99 (1):E81-8 Epub 2013 Dec 20
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Christen D, Melton LJ 3rd, Zwahlen A, Amin S, Khosla S, Muller R. Improved fracture risk assessment based on nonlinear micro-finite element simulations from HRpQCT images at the distal radius. J Bone Miner Res. 2013 Dec; 28(12):2601-8.
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Randall C, Bridges D, Guerri R, Nogues X, Puig L, Torres E, Mellibovsky L, Hoffseth K, Stalbaum T, Srikanth A, Weaver JC, Rosen S, Barnard H, Brimer D, Proctor A, Candy J, Saldana C, Chandrasekar S, Lescun T, Nielson CM, Orwoll E, Herthel D, Kopeikin H, Yang HT, Farr JN, McCready L, Khosla S, Diez-Perez A, Hansma PK. Applications of a New Handheld Reference Point Indentation Instrument Measuring Bone Material Strength. J Med Device. 2013 Dec; 7(4):410051-6. Epub 2013 Sep 24
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Ota K, Quint P, Weivoda MM, Ruan M, Pederson L, Westendorf JJ, Khosla S, Oursler MJ. Transforming growth factor beta 1 induces CXCL16 and leukemia inhibitory factor expression in osteoclasts to modulate migration of osteoblast progenitors. Bone. 2013 Nov; 57 (1):68-75 Epub 2013 July 25
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Roforth MM, Khosla S, Monroe DG. Identification of Rorbeta targets in cultured osteoblasts and in human bone. Biochem Biophys Res Commun. 2013 Nov 1; 440 (4):768-73 Epub 2013 Oct 11
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Ota K, Quint P, Ruan M, Pederson L, Westendorf JJ, Khosla S, Oursler MJ. TGF-beta induces Wnt10b in osteoclasts from female mice to enhance coupling to osteoblasts. Endocrinology. 2013 Oct; 154 (10):3745-52 Epub 2013 July 16
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Khosla S. Pathogenesis of age-related bone loss in humans. J Gerontol A Biol Sci Med Sci. 2013 Oct; 68 (10):1226-35 Epub 2012 Aug 24
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Ota K, Quint P, Ruan M, Pederson L, Westendorf JJ, Khosla S, Oursler MJ. Sclerostin is expressed in osteoclasts from aged mice and reduces osteoclast-mediated stimulation of mineralization. J Cell Biochem. 2013 Aug; 114 (8):1901-1907
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Amin S, Melton LJ 3rd, Achenbach SJ, Atkinson EJ, Dekutoski MB, Kirmani S, Fischer PR, Khosla S. A distal forearm fracture in childhood is associated with an increased risk for future fragility fractures in adult men, but not women. J Bone Miner Res. 2013 Aug; 28 (8):1751-9
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Ng AC, Melton LJ 3rd, Atkinson EJ, Achenbach SJ, Holets MF, Peterson JM, Khosla S, Drake MT. Relationship of adiposity to bone volumetric density and microstructure in men and women across the adult lifespan. Bone. 2013 Jul; 55 (1):119-25 Epub 2013 Feb 18
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Nicks KM, Amin S, Melton LJ 3rd, Atkinson EJ, McCready LK, Riggs BL, Engelke K, Khosla S. Three-dimensional structural analysis of the proximal femur in an age-stratified sample of women. Bone. 2013 Jul; 55 (1):179-88 Epub 2013 Feb 26
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Burghardt AJ, Pialat JB, Kazakia GJ, Boutroy S, Engelke K, Patsch JM, Valentinitsch A, Liu D, Szabo E, Bogado CE, Zanchetta MB, McKay HA, Shane E, Boyd SK, Bouxsein ML, Chapurlat R, Khosla S, Majumdar S. Multicenter precision of cortical and trabecular bone quality measures assessed by high-resolution peripheral quantitative computed tomography. J Bone Miner Res. 2013 Mar; 28(3):524-36.
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Carballido-Gamio J, Harnish R, Saeed I, Streeper T, Sigurdsson S, Amin S, Atkinson EJ, Therneau TM, Siggeirsdottir K, Cheng X, Melton LJ 3rd, Keyak J, Gudnason V, Khosla S, Harris TB, Lang TF. Proximal femoral density distribution and structure in relation to age and hip fracture risk in women. J Bone Miner Res. 2013 Mar; 28(3):537-46.
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Quint P, Ruan M, Pederson L, Kassem M, Westendorf JJ, Khosla S, Oursler MJ. Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through S1P activation of complementary kinase pathways. J Biol Chem. 2013 Feb 22; 288 (8):5398-406 Epub 2013 Jan 07
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Farr JN, Khosla S, Miyabara Y, Miller VM, Kearns AE. Effects of estrogen with micronized progesterone on cortical and trabecular bone mass and microstructure in recently postmenopausal women. J Clin Endocrinol Metab. 2013 Feb; 98 (2):E249-57 Epub 2013 Jan 15
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Flammer AJ, Martin EA, Gossl M, Widmer RJ, Lennon RJ, Sexton JA, Loeffler D, Khosla S, Lerman LO, Lerman A. Polyphenol-rich cranberry juice has a neutral effect on endothelial function but decreases the fraction of osteocalcin-expressing endothelial progenitor cells. Eur J Nutr. 2013 Feb; 52 (1):289-96 Epub 2012 Mar 02
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Klingberg E, Lorentzon M, Gothlin J, Mellstrom D, Geijer M, Ohlsson C, Atkinson EJ, Khosla S, Carlsten H, Forsblad-d'Elia H. Bone microarchitecture in ankylosing spondylitis and the association with bone mineral density, fractures, and syndesmophytes. Arthritis Res Ther. 2013; 15(6):R179.
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Carballido-Gamio J, Harnish R, Saeed I, Streeper T, Sigurdsson S, Amin S, Atkinson EJ, Therneau TM, Siggeirsdottir K, Cheng X, Melton LJ, Keyak JH, Gudnason V, Khosla S, Harris TB, Lang TF. Structural patterns of the proximal femur in relation to age and hip fracture risk in women. Bone. 2013; 57(1):290-9.
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Peris P, Atkinson EJ, Gossl M, Kane TL, McCready LK, Lerman A, Khosla S, McGregor UI. Effects of bisphosphonate treatment on circulating osteogenic endothelial progenitor cells in postmenopausal women. Mayo Clin Proc. 2013 Jan; 88 (1):46-55 Epub 2012 Dec 08
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Giambini H, Khosla S, Nassr A, Zhao C, An KN. Longitudinal changes in lumbar bone mineral density distribution may increase the risk of wedge fractures. Clin Biomech (Bristol, Avon). 2013 Jan; 28 (1):10-4 Epub 2012 Nov 08
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Riggs BL, Khosla S, Melton LJ 3rd. Better tools for assessing osteoporosis. J Clin Invest. 2012 Dec; 122 (12):4323-4 Epub 2012 Dec 03
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Flammer AJ, Gossl M, Li J, Matsuo Y, Reriani M, Loeffler D, Simari RD, Lerman LO, Khosla S, Lerman A. Patients with an HbA1c in the prediabetic and diabetic range have higher numbers of circulating cells with osteogenic and endothelial progenitor cell markers. J Clin Endocrinol Metab. 2012 Dec; 97 (12):4761-8 Epub 2012 Sept 26
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Flammer AJ, Gossl M, Widmer RJ, Reriani M, Lennon R, Loeffler D, Shonyo S, Simari RD, Lerman LO, Khosla S, Lerman A. Osteocalcin positive CD133+/CD34-/KDR+ progenitor cells as an independent marker for unstable atherosclerosis. Eur Heart J. 2012 Dec; 33 (23):2963-9 Epub 2012 July 31
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Gossl M, Khosla S, Zhang X, Higano N, Jordan KL, Loeffler D, Enriquez-Sarano M, Lennon RJ, McGregor U, Lerman LO, Lerman A. Role of circulating osteogenic progenitor cells in calcific aortic stenosis. J Am Coll Cardiol. 2012 Nov 6; 60 (19):1945-53 Epub 2012 Oct 10
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Chokalingam K, Roforth MM, Nicks KM, McGregor U, Fraser D, Khosla S, Monroe DG. Examination of ERalpha signaling pathways in bone of mutant mouse models reveals the importance of ERE-dependent signaling. Endocrinology. 2012 Nov; 153 (11):5325-33 Epub 2012 Sept 26
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Bush NC, Basu R, Rizza RA, Nair KS, Khosla S, Jensen MD. Insulin-mediated FFA suppression is associated with triglyceridemia and insulin sensitivity independent of adiposity. J Clin Endocrinol Metab. 2012 Nov; 97 (11):4130-8 Epub 2012 Aug 29
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Farr JN, Charkoudian N, Barnes JN, Monroe DG, McCready LK, Atkinson EJ, Amin S, Melton LJ 3rd, Joyner MJ, Khosla S. Relationship of sympathetic activity to bone microstructure, turnover, and plasma osteopontin levels in women. J Clin Endocrinol Metab. 2012 Nov; 97 (11):4219-27 Epub 2012 Sept 04
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Khosla S, Oursler MJ, Monroe DG. Estrogen and the skeleton. Trends Endocrinol Metab. 2012 Nov; 23 (11):576-81 Epub 2012 May 16
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Lebrasseur NK, Achenbach SJ, Melton LJ 3rd, Amin S, Khosla S. Skeletal muscle mass is associated with bone geometry and microstructure and serum insulin-like growth factor binding protein-2 levels in adult women and men. J Bone Miner Res. 2012 Oct; 27 (10):2159-69
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Drake MT, Khosla S. Male osteoporosis. Endocrinol Metab Clin North Am. 2012 Sep; 41 (3):629-41 Epub 2012 June 17
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Modder UI, Rudnik V, Liu G, Khosla S, Monroe DG. A DNA binding mutation in estrogen receptor-alpha leads to suppression of Wnt signaling via beta-catenin destabilization in osteoblasts. J Cell Biochem. 2012 Jul; 113 (7):2248-55
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Khosla S, Bilezikian JP, Dempster DW, Lewiecki EM, Miller PD, Neer RM, Recker RR, Shane E, Shoback D, Potts JT. Benefits and risks of bisphosphonate therapy for osteoporosis. J Clin Endocrinol Metab. 2012 Jul; 97 (7):2272-82 Epub 2012 Apr 20
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Fadini GP, Rattazzi M, Matsumoto T, Asahara T, Khosla S. Emerging role of circulating calcifying cells in the bone-vascular axis. Circulation. 2012 Jun 5; 125(22):2772-81.
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Melton LJ 3rd, Hartmann LC, Achenbach SJ, Atkinson EJ, Therneau TM, Khosla S. Fracture risk in women with breast cancer: a population-based study. J Bone Miner Res. 2012 May; 27 (5):1196-205
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Urbieta-Caceres VH, Syed FA, Lin J, Zhu XY, Jordan KL, Bell CC, Bentley MD, Lerman A, Khosla S, Lerman LO. Age-dependent renal cortical microvascular loss in female mice. Am J Physiol Endocrinol Metab. 2012 Apr 15; 302 (8):E979-86 Epub 2012 Feb 07
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Roforth MM, Liu G, Khosla S, Monroe DG. Examination of nuclear receptor expression in osteoblasts reveals Rorbeta as an important regulator of osteogenesis. J Bone Miner Res. 2012 Apr; 27 (4):891-901
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Nicks KM, Amin S, Atkinson EJ, Riggs BL, Melton LJ 3rd, Khosla S. Relationship of age to bone microstructure independent of areal bone mineral density. J Bone Miner Res. 2012 Mar; 27 (3):637-44
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Cheung AM, Tile L, Cardew S, Pruthi S, Robbins J, Tomlinson G, Kapral MK, Khosla S, Majumdar S, Erlandson M, Scher J, Hu H, Demaras A, Lickley L, Bordeleau L, Elser C, Ingle J, Richardson H, Goss PE. Bone density and structure in healthy postmenopausal women treated with exemestane for the primary prevention of breast cancer: a nested substudy of the MAP.3 randomised controlled trial. Lancet Oncol. 2012 Mar; 13(3):275-84. Epub 2012 Feb 07.
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Modder UI, Roforth MM, Nicks KM, Peterson JM, McCready LK, Monroe DG, Khosla S. Characterization of mesenchymal progenitor cells isolated from human bone marrow by negative selection. Bone. 2012 Mar; 50 (3):804-10 Epub 2011 Dec 28
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Kirmani S, Amin S, McCready LK, Atkinson EJ, Melton LJ 3rd, Muller R, Khosla S. Sclerostin levels during growth in children. Osteoporos Int. 2012 Mar; 23 (3):1123-30 Epub 2011 May 27
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Gossl M, Khosla S, Zhang X, Higano N, Jordan KL, Loeffler D, Enriquez-Sarano M, Lennon RJ, McGregor U, Lerman LO, Lerman A. Erratum: Role of circulating osteogenic progenitor cells in calcific aortic stenosis (Journal of the American College of Cardiology (2012) 60 (194553)). J Am Coll Cardiol. 2012; 60(24):2606.
Melton LJ 3rd, Atkinson EJ, Achenbach SJ, Kanis JA, Therneau TM, Johansson H, Khosla S, Amin S. Potential Extensions of the US FRAX Algorithm. J Osteoporos. 2012; 2012:528790 Epub 2012 Aug 15
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Amin S, Khosla S. Sex- and age-related differences in bone microarchitecture in men relative to women assessed by high-resolution peripheral quantitative computed tomography. J Osteoporos. 2012; 2012:129760 Epub 2012 Feb 16
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Kumar A, Ruan M, Clifton K, Syed F, Khosla S, Oursler MJ. TGF-beta mediates suppression of adipogenesis by estradiol through connective tissue growth factor induction. Endocrinology. 2012 Jan; 153 (1):254-63 Epub 2011 Nov 08
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Ng AC, Khosla S, Charatcharoenwitthaya N, Kumar SK, Achenbach SJ, Holets MF, McCready LK, Melton LJ 3rd, Kyle RA, Rajkumar SV, Drake MT. Bone microstructural changes revealed by high-resolution peripheral quantitative computed tomography imaging and elevated DKK1 and MIP-1alpha levels in patients with MGUS. Blood. 2011 Dec 15; 118 (25):6529-34 Epub 2011 Oct 31
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Nelson ER, DuSell CD, Wang X, Howe MK, Evans G, Michalek RD, Umetani M, Rathmell JC, Khosla S, Gesty-Palmer D, McDonnell DP. The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. Endocrinology. 2011 Dec; 152(12):4691-705. Epub 2011 Sep 20.
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Marantes I, Achenbach SJ, Atkinson EJ, Khosla S, Melton LJ 3rd, Amin S. Is vitamin D a determinant of muscle mass and strength? J Bone Miner Res. 2011 Dec; 26 (12):2860-71
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Undale A, Fraser D, Hefferan T, Kopher RA, Herrick J, Evans GL, Li X, Kakar S, Hayes M, Atkinson E, Yaszemski MJ, Kaufman DS, Westendorf JJ, Khosla S. Induction of fracture repair by mesenchymal cells derived from human embryonic stem cells or bone marrow. J Orthop Res. 2011 Dec; 29 (12):1804-11 Epub 2011 June 14
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Melton LJ 3rd, Riggs BL, Muller R, Achenbach SJ, Christen D, Atkinson EJ, Amin S, Khosla S. Determinants of forearm strength in postmenopausal women. Osteoporos Int. 2011 Dec; 22 (12):3047-54 Epub 2011 Feb 10
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Kanis JA, Bianchi G, Bilezikian JP, Kaufman JM, Khosla S, Orwoll E, Seeman E. Towards a diagnostic and therapeutic consensus in male osteoporosis. Osteoporos Int. 2011 Nov; 22(11):2789-98. Epub 2011 Apr 21.
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Khosla S, Bellido TM, Drezner MK, Gordon CM, Harris TB, Kiel DP, Kream BE, LeBoff MS, Lian JB, Peterson CA, Rosen CJ, Williams JP, Winer KK, Sherman SS. Forum on aging and skeletal health: summary of the proceedings of an ASBMR workshop. J Bone Miner Res. 2011 Nov; 26 (11):2565-78 Epub 2011 Sept 13
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Abdallah BM, Bay-Jensen AC, Srinivasan B, Tabassi NC, Garnero P, Delaisse JM, Khosla S, Kassem M. Estrogen inhibits Dlk1/FA1 production: a potential mechanism for estrogen effects on bone turnover. J Bone Miner Res. 2011 Oct; 26(10):2548-51.
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Drake MT, Srinivasan B, Modder UI, Ng AC, Undale AH, Roforth MM, Peterson JM, McCready LK, Riggs BL, Khosla S. Effects of intermittent parathyroid hormone treatment on osteoprogenitor cells in postmenopausal women. Bone. 2011 Sep; 49 (3):349-55 Epub 2011 May 11
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Kirmani S, Atkinson EJ, Melton LJ 3rd, Riggs BL, Amin S, Khosla S. Relationship of testosterone and osteocalcin levels during growth. J Bone Miner Res. 2011 Sep; 26 (9):2212-6
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Modder UI, Roforth MM, Hoey K, McCready LK, Peterson JM, Monroe DG, Oursler MJ, Khosla S. Effects of estrogen on osteoprogenitor cells and cytokines/bone-regulatory factors in postmenopausal women. Bone. 2011 Aug; 49 (2):202-7 Epub 2011 Apr 29
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Syed FA, Fraser DG, Monroe DG, Khosla S. Distinct effects of loss of classical estrogen receptor signaling versus complete deletion of estrogen receptor alpha on bone. Bone. 2011 Aug; 49 (2):208-16 Epub 2011 Mar 31
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Melton LJ 3rd, Lieber MM, Atkinson EJ, Achenbach SJ, Zincke H, Therneau TM, Khosla S. Fracture risk in men with prostate cancer: a population-based study. J Bone Miner Res. 2011 Aug; 26 (8):1808-15
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Amin S, Kopperdhal DL, Melton LJ 3rd, Achenbach SJ, Therneau TM, Riggs BL, Keaveny TM, Khosla S. Association of hip strength estimates by finite-element analysis with fractures in women and men. J Bone Miner Res. 2011 Jul; 26 (7):1593-600
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Basu R, Peterson J, Rizza R, Khosla S. Effects of physiological variations in circulating insulin levels on bone turnover in humans. J Clin Endocrinol Metab. 2011 May; 96 (5):1450-5 Epub 2011 Feb 16
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Modder UI, Oursler MJ, Khosla S, Monroe DG. Wnt10b activates the Wnt, notch, and NFkappaB pathways in U2OS osteosarcoma cells. J Cell Biochem. 2011 May; 112 (5):1392-402
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Melton LJ 3rd, Marquez MA, McCready LK, Achenbach SJ, Riggs BL, Amin S, Khosla S. Trabecular bone deficits among Vietnamese immigrants. Osteoporos Int. 2011 May; 22 (5):1627-31 Epub 2010 July 24
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Rachner TD, Khosla S, Hofbauer LC. Osteoporosis: now and the future. Lancet. 2011 Apr 9; 377(9773):1276-87. Epub 2011 Mar 28.
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Khosla S. The bone and beyond: a shift in calcium. Nat Med. 2011 Apr; 17 (4):430-1
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Khosla S, Melton LJ 3rd, Riggs BL. The unitary model for estrogen deficiency and the pathogenesis of osteoporosis: is a revision needed? J Bone Miner Res. 2011 Mar; 26 (3):441-51
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Koutsari C, Basu R, Rizza RA, Nair KS, Khosla S, Jensen MD. Nonoxidative free fatty acid disposal is greater in young women than men. J Clin Endocrinol Metab. 2011 Feb; 96 (2):541-7 Epub 2010 Dec 01
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Dragomir-Daescu D, Op Den Buijs J, McEligot S, Dai Y, Entwistle RC, Salas C, Melton LJ 3rd, Bennet KE, Khosla S, Amin S. Robust QCT/FEA models of proximal femur stiffness and fracture load during a sideways fall on the hip. Ann Biomed Eng. 2011 Feb; 39 (2):742-55 Epub 2010 Oct 29
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Kawai M, Modder UI, Khosla S, Rosen CJ. Emerging therapeutic opportunities for skeletal restoration. Nat Rev Drug Discov. 2011 Feb; 10(2):141-56.
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Modder UI, Hoey KA, Amin S, McCready LK, Achenbach SJ, Riggs BL, Melton LJ 3rd, Khosla S. Relation of age, gender, and bone mass to circulating sclerostin levels in women and men. J Bone Miner Res. 2011 Feb; 26 (2):373-9
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Cummins NW, Klicpera A, Sainski AM, Bren GD, Khosla S, Westendorf JJ, Badley AD. Human immunodeficiency virus envelope protein Gp120 induces proliferation but not apoptosis in osteoblasts at physiologic concentrations. PLoS One. 2011; 6 (9):e24876 Epub 2011 Sept 12
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Wuermser LA, Achenbach SJ, Amin S, Khosla S, Melton LJ 3rd. What accounts for rib fractures in older adults? J Osteoporos. 2011; 2011:457591 Epub 2011 Oct 19
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Modder UI, Clowes JA, Hoey K, Peterson JM, McCready L, Oursler MJ, Riggs BL, Khosla S. Regulation of circulating sclerostin levels by sex steroids in women and in men. J Bone Miner Res. 2011 Jan; 26 (1):27-34
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Lewiecki EM, Bilezikian JP, Khosla S, Marcus R, McClung MR, Miller PD, Watts NB, Maricic M. Osteoporosis update from the 2010 santa fe bone symposium. J Clin Densitom. 2011 Jan-Mar; 14(1):1-21.
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Undale A, Srinivasan B, Drake M, McCready L, Atkinson E, Peterson J, Riggs BL, Amin S, Modder UI, Khosla S. Corrigendum to "Circulating osteogenic cells: Characterization and relationship to rates of bone loss in postmenopausal women" [Bone 47 (2010) 83-92]. Bone. 2011; 48(3):671.
Khosla S, Modder UI, Syed FA. Corrigendum to "Letter to the Editor" [Bone 38 (2006) 289]. Bone. 2011; 48(3):670.
Gossl M, Modder UI, Gulati R, Rihal CS, Prasad A, Loeffler D, Lerman LO, Khosla S, Lerman A. Coronary endothelial dysfunction in humans is associated with coronary retention of osteogenic endothelial progenitor cells. Eur Heart J. 2010 Dec; 31 (23):2909-14 Epub 2010 Oct 08
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Khosla S, Westendorf JJ, Modder UI. Concise review: Insights from normal bone remodeling and stem cell-based therapies for bone repair. Stem Cells. 2010 Dec; 28 (12):2124-8
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Santosa S, Khosla S, McCready LK, Jensen MD. Effects of estrogen and testosterone on resting energy expenditure in older men. Obesity (Silver Spring). 2010 Dec; 18 (12):2392-4 Epub 2010 May 06
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Clarke BL, Khosla S. Female reproductive system and bone. Arch Biochem Biophys. 2010 Nov 1; 503 (1):118-28 Epub 2010 July 14
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Drake MT, Srinivasan B, Modder UI, Peterson JM, McCready LK, Riggs BL, Dwyer D, Stolina M, Kostenuik P, Khosla S. Effects of parathyroid hormone treatment on circulating sclerostin levels in postmenopausal women. J Clin Endocrinol Metab. 2010 Nov; 95 (11):5056-62 Epub 2010 July 14
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Drake MT, McCready LK, Hoey KA, Atkinson EJ, Khosla S. Effects of suppression of follicle-stimulating hormone secretion on bone resorption markers in postmenopausal women. J Clin Endocrinol Metab. 2010 Nov; 95 (11):5063-8 Epub 2010 July 07
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Syed FA, Modder UI, Roforth M, Hensen I, Fraser DG, Peterson JM, Oursler MJ, Khosla S. Effects of chronic estrogen treatment on modulating age-related bone loss in female mice. J Bone Miner Res. 2010 Nov; 25 (11):2438-46
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Tchkonia T, Morbeck DE, Von Zglinicki T, Van Deursen J, Lustgarten J, Scrable H, Khosla S, Jensen MD, Kirkland JL. Fat tissue, aging, and cellular senescence. Aging Cell. 2010 Oct; 9 (5):667-84 Epub 2010 Aug 15
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Rosen CJ, Khosla S. Placebo-controlled trials in osteoporosis--proceeding with caution. N Engl J Med. 2010 Sep 30; 363(14):1365-7; discussion e22.
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Melton LJ 3rd, Riggs BL, Keaveny TM, Achenbach SJ, Kopperdahl D, Camp JJ, Rouleau PA, Amin S, Atkinson EJ, Robb RA, Therneau TM, Khosla S. Relation of vertebral deformities to bone density, structure, and strength. J Bone Miner Res. 2010 Sep; 25 (9):1922-30
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Khosla S. Update on estrogens and the skeleton. J Clin Endocrinol Metab. 2010 Aug; 95 (8):3569-77
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DuSell CD, Nelson ER, Wang X, Abdo J, Modder UI, Umetani M, Gesty-Palmer D, Javitt NB, Khosla S, McDonnell DP. The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis. Endocrinology. 2010 Aug; 151(8):3675-85. Epub 2010 May 25.
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Undale A, Srinivasan B, Drake M, McCready L, Atkinson E, Peterson J, Riggs BL, Amin S, Modder UI, Khosla S. Circulating osteogenic cells: characterization and relationship to rates of bone loss in postmenopausal women. Bone. 2010 Jul; 47 (1):83-92 Epub 2010 Mar 31
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Melton LJ 3rd, Christen D, Riggs BL, Achenbach SJ, Muller R, van Lenthe GH, Amin S, Atkinson EJ, Khosla S. Assessing forearm fracture risk in postmenopausal women. Osteoporos Int. 2010 Jul; 21 (7):1161-9 Epub 2009 Aug 28
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Clarke BL, Khosla S. Physiology of bone loss. Radiol Clin North Am. 2010 May; 48 (3):483-95
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Keaveny TM, Kopperdahl DL, Melton LJ III, Hoffmann PF, Amin S, Riggs BL, Khosla S. Age-dependence of femoral strength in white women and men. J Bone Miner Res. 2010 May; 25(5):994-1001.
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Khosla S. Pathogenesis of Osteoporosis. Transl Endocrinol Metab. 2010 Apr; 1 (1):55-86
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Modder UI, Achenbach SJ, Amin S, Riggs BL, Melton LJ 3rd, Khosla S. Relation of serum serotonin levels to bone density and structural parameters in women. J Bone Miner Res. 2010 Feb; 25 (2):415-22
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Kopher RA, Penchev VR, Islam MS, Hill KL, Khosla S, Kaufman DS. Human embryonic stem cell-derived CD34+ cells function as MSC progenitor cells. Bone. 2010; 47(4):718-28.
Khosla S. Update in male osteoporosis. J Clin Endocrinol Metab. 2010 Jan; 95 (1):3-10
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Clarke BL, Khosla S. Modulators of androgen and estrogen receptor activity. Crit Rev Eukaryot Gene Expr. 2010; 20 (4):275-94
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Undale AH, Westendorf JJ, Yaszemski MJ, Khosla S. Mesenchymal stem cells for bone repair and metabolic bone diseases. Mayo Clin Proc. 2009 Oct; 84 (10):893-902
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Clarke BL, Khosla S. Assessing the true impact of recurrent fractures on fracture risk. J Bone Miner Res. 2009 Sep; 24 (9):1512-4
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Koutsari C, Ali AH, Nair KS, Rizza RA, O'Brien P, Khosla S, Jensen MD. Fatty acid metabolism in the elderly: effects of dehydroepiandrosterone and testosterone replacement in hormonally deficient men and women. J Clin Endocrinol Metab. 2009 Sep; 94 (9):3414-23 Epub 2009 June 30
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Modder UI, Monroe DG, Fraser DG, Spelsberg TC, Rosen CJ, Gehin M, Chambon P, O'Malley BW, Khosla S. Skeletal consequences of deletion of steroid receptor coactivator-2/transcription intermediary factor-2. J Biol Chem. 2009 Jul 10; 284 (28):18767-77 Epub 2009 May 07
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Clarke BL, Khosla S. New selective estrogen and androgen receptor modulators. Curr Opin Rheumatol. 2009 Jul; 21 (4):374-9
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Kirmani S, Christen D, van Lenthe GH, Fischer PR, Bouxsein ML, McCready LK, Melton LJ 3rd, Riggs BL, Amin S, Muller R, Khosla S. Bone structure at the distal radius during adolescent growth. J Bone Miner Res. 2009 Jun; 24 (6):1033-42
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Rule AD, Bailey KR, Schwartz GL, Khosla S, Lieske JC, Melton LJ 3rd. For estimating creatinine clearance measuring muscle mass gives better results than those based on demographics. Kidney Int. 2009 May; 75 (10):1071-8 Epub 2009 Jan 28
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Clowes JA, Eghbali-Fatourechi GZ, McCready L, Oursler MJ, Khosla S, Riggs BL. Estrogen action on bone marrow osteoclast lineage cells of postmenopausal women in vivo. Osteoporos Int. 2009 May; 20 (5):761-9 Epub 2008 Sept 04
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Clarke BL, Khosla S. Androgens and bone. Steroids. 2009 Mar; 74 (3):296-305 Epub 2008 Oct 17
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Henderson GC, Dhatariya K, Ford GC, Klaus KA, Basu R, Rizza RA, Jensen MD, Khosla S, O'Brien P, Nair KS. Higher muscle protein synthesis in women than men across the lifespan, and failure of androgen administration to amend age-related decrements. FASEB J. 2009 Feb; 23(2):631-41. Epub 2008 Sep 30.
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Pederson L, Ruan M, Westendorf JJ, Khosla S, Oursler MJ. Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate. Proc Natl Acad Sci U S A. 2008 Dec 30; 105 (52):20764-9 Epub 2008 Dec 15
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Melton LJ 3rd, Riggs BL, Leibson CL, Achenbach SJ, Camp JJ, Bouxsein ML, Atkinson EJ, Robb RA, Khosla S. A bone structural basis for fracture risk in diabetes. J Clin Endocrinol Metab. 2008 Dec; 93 (12):4804-9 Epub 2008 Sept 16
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McCarthy JT, Rule AD, Achenbach SJ, Bergstralh EJ, Khosla S, Melton LJ 3rd. Use of renal function measurements for assessing fracture risk in postmenopausal women. Mayo Clin Proc. 2008 Nov; 83 (11):1231-9
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Gossl M, Modder UI, Atkinson EJ, Lerman A, Khosla S. Osteocalcin expression by circulating endothelial progenitor cells in patients with coronary atherosclerosis. J Am Coll Cardiol. 2008 Oct 14; 52 (16):1314-25
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Khosla S, Amin S, Singh RJ, Atkinson EJ, Melton LJ 3rd, Riggs BL. Comparison of sex steroid measurements in men by immunoassay versus mass spectroscopy and relationships with cortical and trabecular volumetric bone mineral density. Osteoporos Int. 2008 Oct; 19 (10):1465-71 Epub 2008 Mar 13
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Chow JT, Khosla S, Melton LJ 3rd, Atkinson EJ, Camp JJ, Kearns AE. Abdominal aortic calcification, BMD, and bone microstructure: a population-based study. J Bone Miner Res. 2008 Oct; 23 (10):1601-12
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Syed FA, Oursler MJ, Hefferanm TE, Peterson JM, Riggs BL, Khosla S. Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women. Osteoporos Int. 2008 Sep; 19 (9):1323-30 Epub 2008 Feb 15
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Drake MT, Clarke BL, Khosla S. Bisphosphonates: mechanism of action and role in clinical practice. Mayo Clin Proc. 2008 Sep; 83 (9):1032-45
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Melton LJ 3rd, Leibson CL, Achenbach SJ, Therneau TM, Khosla S. Fracture risk in type 2 diabetes: update of a population-based study. J Bone Miner Res. 2008 Aug; 23 (8):1334-42
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Hawse JR, Subramaniam M, Monroe DG, Hemmingsen AH, Ingle JN, Khosla S, Oursler MJ, Spelsberg TC. Estrogen receptor beta isoform-specific induction of transforming growth factor beta-inducible early gene-1 in human osteoblast cells: an essential role for the activation function 1 domain. Mol Endocrinol. 2008 Jul; 22 (7):1579-95 Epub 2008 May 15
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Bhattacharyya S, Siegel ER, Achenbach SJ, Khosla S, Suva LJ. Serum biomarker profile associated with high bone turnover and BMD in postmenopausal women. J Bone Miner Res. 2008 Jul; 23(7):1106-17.
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Khosla S, Amin S, Orwoll E. Osteoporosis in men. Endocr Rev. 2008 Jun; 29 (4):441-64 Epub 2008 May 01
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Sanyal A, Hoey KA, Modder UI, Lamsam JL, McCready LK, Peterson JM, Achenbach SJ, Oursler MJ, Khosla S. Regulation of bone turnover by sex steroids in men. J Bone Miner Res. 2008 May; 23 (5):705-14
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Rickard DJ, Iwaniec UT, Evans G, Hefferan TE, Hunter JC, Waters KM, Lydon JP, O'Malley BW, Khosla S, Spelsberg TC, Turner RT. Bone growth and turnover in progesterone receptor knockout mice. Endocrinology. 2008 May; 149 (5):2383-90 Epub 2008 Feb 14
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Kearns AE, Khosla S, Kostenuik PJ. Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease. Endocr Rev. 2008 Apr; 29 (2):155-92 Epub 2007 Dec 05
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Tosteson AN, Melton LJ 3rd, Dawson-Hughes B, Baim S, Favus MJ, Khosla S, Lindsay RL, National Osteoporosis Foundation Guide Committee. Cost-effective osteoporosis treatment thresholds: the United States perspective. Osteoporos Int. 2008 Apr; 19(4):437-47. Epub 2008 Feb 22.
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Dawson-Hughes B, Tosteson AN, Melton LJ 3rd, Baim S, Favus MJ, Khosla S, Lindsay RL, National Osteoporosis Foundation Guide Committee. Implications of absolute fracture risk assessment for osteoporosis practice guidelines in the USA. Osteoporos Int. 2008 Apr; 19(4):449-58. Epub 2008 Feb 22.
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Rudnik V, Sanyal A, Syed FA, Monroe DG, Spelsberg TC, Oursler MJ, Khosla S. Loss of ERE binding activity by estrogen receptor-alpha alters basal and estrogen-stimulated bone-related gene expression by osteoblastic cells. J Cell Biochem. 2008 Feb 15; 103 (3):896-907
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Modder UI, Sanyal A, Xu J, O'Malley BW, Spelsberg TC, Khosla S. The skeletal response to estrogen is impaired in female but not in male steroid receptor coactivator (SRC)-1 knock out mice. Bone. 2008 Feb; 42 (2):414-21 Epub 2007 Nov 04
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Riggs BL, Melton LJ, Robb RA, Camp JJ, Atkinson EJ, McDaniel L, Amin S, Rouleau PA, Khosla S. A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men. J Bone Miner Res. 2008 Feb; 23 (2):205-14
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Modder UI, Khosla S. Skeletal stem/osteoprogenitor cells: current concepts, alternate hypotheses, and relationship to the bone remodeling compartment. J Cell Biochem. 2008 Feb 1; 103 (2):393-400
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Khosla S, Westendorf JJ, Oursler MJ. Building bone to reverse osteoporosis and repair fractures. J Clin Invest. 2008 Feb; 118 (2):421-8
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Melton LJ 3rd, Riggs BL, Keaveny TM, Achenbach SJ, Hoffmann PF, Camp JJ, Rouleau PA, Bouxsein ML, Amin S, Atkinson EJ, Robb RA, Khosla S. Structural determinants of vertebral fracture risk. J Bone Miner Res. 2007 Dec; 22 (12):1885-92
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Sokolnicki LA, Khosla S, Charkoudian N. Effects of testosterone and estradiol on cutaneous vasodilation during local warming in older men. Am J Physiol Endocrinol Metab. 2007 Nov; 293(5):E1426-9. Epub 2007 Sep 25.
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Melton LJ 3rd, Riggs BL, van Lenthe GH, Achenbach SJ, Muller R, Bouxsein ML, Amin S, Atkinson EJ, Khosla S. Contribution of in vivo structural measurements and load/strength ratios to the determination of forearm fracture risk in postmenopausal women. J Bone Miner Res. 2007 Sep; 22(9):1442-8.
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Basu R, Dalla Man C, Campioni M, Basu A, Nair KS, Jensen MD, Khosla S, Klee G, Toffolo G, Cobelli C, Rizza RA. Effect of 2 years of testosterone replacement on insulin secretion, insulin action, glucose effectiveness, hepatic insulin clearance, and postprandial glucose turnover in elderly men. Diabetes Care. 2007 Aug; 30 (8):1972-8 Epub 2007 May 11
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Amin S, Riggs BL, Melton LJ 3rd, Achenbach SJ, Atkinson EJ, Khosla S. High serum IGFBP-2 is predictive of increased bone turnover in aging men and women. J Bone Miner Res. 2007 Jun; 22(6):799-807.
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Khosla S, Melton LJ 3rd. Clinical practice. Osteopenia. N Engl J Med. 2007 May 31; 356(22):2293-300.
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Eghbali-Fatourechi GZ, Modder UI, Charatcharoenwitthaya N, Sanyal A, Undale AH, Clowes JA, Tarara JE, Khosla S. Characterization of circulating osteoblast lineage cells in humans. Bone. 2007 May; 40 (5):1370-7 Epub 2007 Jan 04
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Charatcharoenwitthaya N, Khosla S, Atkinson EJ, McCready LK, Riggs BL. Effect of blockade of TNF-alpha and interleukin-1 action on bone resorption in early postmenopausal women. J Bone Miner Res. 2007 May; 22 (5):724-9
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Syed FA, Fraser DG, Spelsberg TC, Rosen CJ, Krust A, Chambon P, Jameson JL, Khosla S. Effects of loss of classical estrogen response element signaling on bone in male mice. Endocrinology. 2007 Apr; 148(4):1902-10.
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Basu R, Dalla Man C, Campioni M, Basu A, Nair KS, Jensen MD, Khosla S, Klee G, Toffolo G, Cobelli C, Rizza RA. Two years of treatment with dehydroepiandrosterone does not improve insulin secretion, insulin action, or postprandial glucose turnover in elderly men or women. Diabetes. 2007 Mar; 56 (3):753-66
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Eriksen EF, Eghbali-Fatourechi GZ, Khosla S. Remodeling and vascular spaces in bone. J Bone Miner Res. 2007 Jan; 22(1):1-6.
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Melton LJ 3rd, Leibson CL, Good AE, Achenbach SJ, Oberg AL, Khosla S. Long-term fracture risk among women with proven endometriosis. Fertil Steril. 2006 Dec; 86(6):1576-83. Epub 2006 Oct 24.
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Melton LJ 3rd, Riggs BL, Achenbach SJ, Amin S, Camp JJ, Rouleau PA, Robb RA, Oberg AL, Khosla S. Does reduced skeletal loading account for age-related bone loss? J Bone Miner Res. 2006 Dec; 21(12):1847-55.
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Nair KS, Rizza RA, O'Brien P, Dhatariya K, Short KR, Nehra A, Vittone JL, Klee GG, Basu A, Basu R, Cobelli C, Toffolo G, Dalla Man C, Tindall DJ, Melton LJ 3rd, Smith GE, Khosla S, Jensen MD. DHEA in elderly women and DHEA or testosterone in elderly men. N Engl J Med. 2006 Oct 19; 355 (16):1647-59
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Wierman ME, Basson R, Davis SR, Khosla S, Miller KK, Rosner W, Santoro N. Androgen therapy in women: an Endocrine Society Clinical Practice guideline. J Clin Endocrinol Metab. 2006 Oct; 91(10):3697-710. Epub 2006 Oct 03.
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Monroe DG, Secreto FJ, Hawse JR, Subramaniam M, Khosla S, Spelsberg TC. Estrogen receptor isoform-specific regulation of the retinoblastoma-binding protein 1 (RBBP1) gene: roles of AF1 and enhancer elements. J Biol Chem. 2006 Sep 29; 281 (39):28596-604 Epub 2006 July 26
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Bouxsein ML, Melton LJ 3rd, Riggs BL, Muller J, Atkinson EJ, Oberg AL, Robb RA, Camp JJ, Rouleau PA, McCollough CH, Khosla S. Age- and sex-specific differences in the factor of risk for vertebral fracture: a population-based study using QCT. J Bone Miner Res. 2006 Sep; 21(9):1475-82.
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Perrien DS, Achenbach SJ, Bledsoe SE, Walser B, Suva LJ, Khosla S, Gaddy D. Bone turnover across the menopause transition: correlations with inhibins and follicle-stimulating hormone. J Clin Endocrinol Metab. 2006 May; 91(5):1848-54. Epub 2006 Jan 31.
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Khosla S, Eghbali-Fatourechi GZ. Circulating cells with osteogenic potential. Ann N Y Acad Sci. 2006 Apr; 1068:489-97.
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Khosla S, Melton LJ 3rd, Achenbach SJ, Oberg AL, Riggs BL. Hormonal and biochemical determinants of trabecular microstructure at the ultradistal radius in women and men. J Clin Endocrinol Metab. 2006 Mar; 91(3):885-91. Epub 2005 Dec 20.
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Riggs BL, Melton LJ 3rd, Robb RA, Camp JJ, Atkinson EJ, Oberg AL, Rouleau PA, McCollough CH, Khosla S, Bouxsein ML. Population-based analysis of the relationship of whole bone strength indices and fall-related loads to age- and sex-specific patterns of hip and wrist fractures. J Bone Miner Res. 2006 Feb; 21: (2)315-23.
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Khosla S, Riggs BL, Atkinson EJ, Oberg AL, McDaniel LJ, Holets M, Peterson JM, Melton LJ 3rd. Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment. J Bone Miner Res. 2006 Jan; 21 (1):124-31 Epub 2005 Oct 03
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Seeman E, Bianchi G, Khosla S, Kanis JA, Orwoll E. Bone fragility in men--where are we? Osteoporos Int. 2006; 17(11):1577-83. Epub 2006 Aug 01.
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Monroe DG, Secreto FJ, Khosla S, Spelsberg TC. The classical estrogen receptor transcriptional pathway: Implications in human osteoblasts. Clinical Reviews in Bone & Mineral Metabolism. 2006; 4(2):129-40.
Koka S, Forde MD, Khosla S. Systemic assessments utilizing saliva: part 2 osteoporosis and use of saliva to measure bone turnover. Int J Prosthodont. 2006 Jan-Feb; 19(1):53-60.
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Wermers RA, Khosla S, Atkinson EJ, Achenbach SJ, Oberg AL, Grant CS, Melton LJ 3rd. Incidence of primary hyperparathyroidism in Rochester, Minnesota, 1993-2001: an update on the changing epidemiology of the disease. J Bone Miner Res. 2006 Jan; 21 (1):171-7 Epub 2005 Sept 19
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Clowes JA, Riggs BL, Khosla S. The role of the immune system in the pathophysiology of osteoporosis. Immunol Rev. 2005 Dec; 208:207-27
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Melton LJ 3rd, Looker AC, Shepherd JA, O'Connor MK, Achenbach SJ, Riggs BL, Khosla S. Osteoporosis assessment by whole body region vs. site-specific DXA. Osteoporos Int. 2005 Dec; 16 (12):1558-64 Epub 2005 Apr 06
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Khosla S, Riggs BL. Pathophysiology of age-related bone loss and osteoporosis. Endocrinol Metab Clin North Am. 2005 Dec; 34 (4):1015-30, xi
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Syed FA, Modder UI, Fraser DG, Spelsberg TC, Rosen CJ, Krust A, Chambon P, Jameson JL, Khosla S. Skeletal effects of estrogen are mediated by opposing actions of classical and nonclassical estrogen receptor pathways. J Bone Miner Res. 2005 Nov; 20 (11):1992-2001 Epub 2005 July 18
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Khosla S, Riggs BL, Robb RA, Camp JJ, Achenbach SJ, Oberg AL, Rouleau PA, Melton LJ 3rd. Relationship of volumetric bone density and structural parameters at different skeletal sites to sex steroid levels in women. J Clin Endocrinol Metab. 2005 Sep; 90 (9):5096-103 Epub 2005 July 05
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Clowes JA, Khosla S, Eastell R. Potential role of pancreatic and enteric hormones in regulating bone turnover. J Bone Miner Res. 2005 Sep; 20 (9):1497-506 Epub 2005 May 31
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Monroe DG, Secreto FJ, Subramaniam M, Getz BJ, Khosla S, Spelsberg TC. Estrogen receptor alpha and beta heterodimers exert unique effects on estrogen- and tamoxifen-dependent gene expression in human U2OS osteosarcoma cells. Mol Endocrinol. 2005 Jun; 19(6):1555-68. Epub 2005 Mar 31.
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Eghbali-Fatourechi GZ, Lamsam J, Fraser D, Nagel D, Riggs BL, Khosla S. Circulating osteoblast-lineage cells in humans. N Engl J Med. 2005 May 12; 352(19):1959-66.
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Khosla S, Melton LJ 3rd, Robb RA, Camp JJ, Atkinson EJ, Oberg AL, Rouleau PA, Riggs BL. Relationship of volumetric BMD and structural parameters at different skeletal sites to sex steroid levels in men. J Bone Miner Res. 2005 May; 20 (5):730-40 Epub 2004 Dec 20
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Melton LJ 3rd, Beck TJ, Amin S, Khosla S, Achenbach SJ, Oberg AL, Riggs BL. Contributions of bone density and structure to fracture risk assessment in men and women. Osteoporos Int. 2005 May; 16 (5):460-7 Epub 2005 Feb 02
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Melton LJ 3rd, Atkinson EJ, Khosla S, Oberg AL, Riggs BL. Evaluation of a prediction model for long-term fracture risk. J Bone Miner Res. 2005 Apr; 20: (4)551-6.
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Liu PY, Hoey KA, Mielke KL, Veldhuis JD, Khosla S. A randomized placebo-controlled trial of short-term graded transdermal estradiol in healthy gonadotropin-releasing hormone agonist-suppressed pre- and postmenopausal women: effects on serum markers of bone turnover, insulin-like growth factor-I, and osteoclastogenic mediators. J Clin Endocrinol Metab. 2005 Apr; 90: (4)1953-60.
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Syed F, Khosla S. Mechanisms of sex steroid effects on bone. Biochem Biophys Res Commun 2005 Mar 18; 328(3):688-96.
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Sanyal A, Riggs BL, Spelsberg TC, Khosla S. Bone marrow stromal cells express two distinct splice variants of ER-alpha that are regulated by estrogen. J Cell Biochem. 2005 Jan 1; 94(1):88-97.
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Nagel DE, Khosla S, Sanyal A, Rosen DM, Kumagai Y, Riggs BL. A fragment of the hypophosphatemic factor, MEPE, requires inducible cyclooxygenase-2 to exert potent anabolic effects on normal human marrow osteoblast precursors. J Cell Biochem. 2004 Dec 15; 93(6):1107-14.
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Riggs BL, Melton LJ, Melton Iii LJ 3rd, Robb RA, Camp JJ, Atkinson EJ, Peterson JM, Rouleau PA, McCollough CH, Bouxsein ML, Khosla S. Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites. J Bone Miner Res. 2004 Dec; 19 (12):1945-54 Epub 2004 Sept 20
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Razminia M, Trivedi A, Molnar J, Elbzour M, Guerrero M, Salem Y, Ahmed A, Khosla S, Lubell DL. Validation of a new formula for mean arterial pressure calculation: the new formula is superior to the standard formula. Catheter Cardiovasc Interv. 2004 Dec; 63 (4):419-25
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Guerrero M, Ahmed A, Siddiqui M, Khosla S. Stabilization of renal function following renal artery stent revascularization. J Invasive Cardiol. 2004 Dec; 16 (12):703-6
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Modder UI, Riggs BL, Spelsberg TC, Fraser DG, Atkinson EJ, Arnold R, Khosla S. Dose-response of estrogen on bone versus the uterus in ovariectomized mice. Eur J Endocrinol. 2004 Oct; 151 (4):503-10
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Khosla S. Role of hormonal changes in the pathogenesis of osteoporosis in men. Calcif Tissue Int. 2004 Aug; 75(2):110-3.
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Amin S, Riggs BL, Atkinson EJ, Oberg AL, Melton LJ 3rd, Khosla S. A potentially deleterious role of IGFBP-2 on bone density in aging men and women. J Bone Miner Res. 2004 Jul; 19(7):1075-83. Epub 2004 Mar 22.
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Guerrero M, Syed A, Khosla S. Survival following renal artery stent revascularization: four-year follow-up. J Invasive Cardiol. 2004 Jul; 16 (7):368-71
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Kearns AE, Khosla S. Potential anabolic effects of androgens on bone. Mayo Clin Proc. 2004 Apr; 79 (4 Suppl):S14-8
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Khosla S, Riggs BL, Atkinson EJ, Oberg AL, Mavilia C, Del Monte F, Melton LJ 3rd, Brandi ML. Relationship of estrogen receptor genotypes to bone mineral density and to rates of bone loss in men. J Clin Endocrinol Metab. 2004 Apr; 89(4):1808-16.
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Doran PM, Turner RT, Chen D, Facteau SM, Ludvigson JM, Khosla S, Riggs BL, Russell SJ. Native osteoprotegerin gene transfer inhibits the development of murine osteolytic bone disease induced by tumor xenografts. Exp Hematol. 2004 Apr; 32: (4)351-9.
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Modder UI, Sanyal A, Kearns AE, Sibonga JD, Nishihara E, Xu J, O'Malley BW, Ritman EL, Riggs BL, Spelsberg TC, Khosla S. Effects of loss of steroid receptor coactivator-1 on the skeletal response to estrogen in mice. Endocrinology. 2004 Feb; 145: (2)913-21.
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Melton LJ 3rd, Rajkumar SV, Khosla S, Achenbach SJ, Oberg AL, Kyle RA. Fracture risk in monoclonal gammopathy of undetermined significance. J Bone Miner Res. 2004 Jan; 19(1):25-30.
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Conover CA, Khosla S. Role of extracellular matrix in insulin-like growth factor (IGF) binding protein-2 regulation of IGF-II action in normal human osteoblasts. Growth Horm IGF Res. 2003 Dec; 13 (6):328-35
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Monroe DG, Getz BJ, Johnsen SA, Riggs BL, Khosla S, Spelsberg TC. Estrogen receptor isoform-specific regulation of endogenous gene expression in human osteoblastic cell lines expressing either ERalpha or ERbeta. J Cell Biochem. 2003 Oct 1; 90 (2):315-26
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Khosla S, Melton LJ 3rd, Dekutoski MB, Achenbach SJ, Oberg AL, Riggs BL. Incidence of childhood distal forearm fractures over 30 years: a population-based study. JAMA. 2003 Sep 17; 290 (11):1479-85
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Riggs BL, Khosla S, Atkinson EJ, Dunstan CR, Melton LJ 3rd. Evidence that type I osteoporosis results from enhanced responsiveness of bone to estrogen deficiency. Osteoporos Int. 2003 Sep; 14 (9):728-33 Epub 2003 July 18
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Kennel KA, Riggs BL, Achenbach SJ, Oberg AL, Khosla S. Role of parathyroid hormone in mediating age-related changes in bone resorption in men. Osteoporos Int. 2003 Aug; 14 (8):631-6 Epub 2003 July 08
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Khosla S. Estrogen, selective estrogen receptor modulators and now mechanism-specific ligands of the estrogen or androgen receptor? Trends Pharmacol Sci. 2003 Jun; 24(6):261-3.
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Rickard DJ, Monroe DG, Ruesink TJ, Khosla S, Riggs BL, Spelsberg TC. Phytoestrogen genistein acts as an estrogen agonist on human osteoblastic cells through estrogen receptors alpha and beta. J Cell Biochem. 2003 Jun 1; 89(3):633-46.
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Khosla S. Surrogates for fracture endpoints in clinical trials. J Bone Miner Res. 2003 Jun; 18(6):1146-9.
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Melton LJ 3rd, Khosla S, Malkasian GD, Achenbach SJ, Oberg AL, Riggs BL. Fracture risk after bilateral oophorectomy in elderly women. J Bone Miner Res. 2003 May; 18 (5):900-5
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Locklin RM, Khosla S, Turner RT, Riggs BL. Mediators of the biphasic responses of bone to intermittent and continuously administered parathyroid hormone. J Cell Biochem. 2003 May 1; 89 (1):180-90
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Melton LJ 3rd, Alothman KI, Khosla S, Achenbach SJ, Oberg AL, Zincke H. Fracture risk following bilateral orchiectomy. J Urol. 2003 May; 169(5):1747-50.
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Eghbali-Fatourechi G, Khosla S, Sanyal A, Boyle WJ, Lacey DL, Riggs BL. Role of RANK ligand in mediating increased bone resorption in early postmenopausal women. J Clin Invest. 2003 Apr; 111 (8):1221-30
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Vincent A, Riggs BL, Riggs BL, Atkinson EJ, Oberg AL, Khosla S. Effect of estrogen replacement therapy on parathyroid hormone secretion in elderly postmenopausal women. Menopause. 2003 Mar-Apr; 10 (2):165-71
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Monroe DG, Johnsen SA, Subramaniam M, Getz BJ, Khosla S, Riggs BL, Riggs BL, Spelsberg TC. Mutual antagonism of estrogen receptors alpha and beta and their preferred interactions with steroid receptor coactivators in human osteoblastic cell lines. J Endocrinol. 2003 Mar; 176 (3):349-57
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Khosla S, Bilezikian JP. The role of estrogens in men and androgens in women. Endocrinol Metab Clin North Am. 2003 Mar; 32 (1):195-218
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Maran A, Khosla S, Riggs BL, Zhang M, Ritman EL, Turner RT. Measurement of gene expression following cryogenic micro-CT scanning of human iliac crest biopsies. J Musculoskelet Neuronal Interact. 2003 Mar; 3(1):83-8.
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Khosla S, Kunjummen B, Manda R, Khaleel R, Kular R, Gladson M, Razminia M, Guerrero M, Trivedi A, Vidyarthi V, Elbzour M, Ahmed A. Prevalence of renal artery stenosis requiring revascularization in patients initially referred for coronary angiography. Catheter Cardiovasc Interv. 2003 Mar; 58 (3):400-3
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Shui C, Spelsberg TC, Riggs BL, Khosla S. Changes in Runx2/Cbfa1 expression and activity during osteoblastic differentiation of human bone marrow stromal cells. J Bone Miner Res. 2003 Feb; 18 (2):213-21
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Khosla S, Jain P, Manda R, Razminia M, Guerrero M, Trivedi A, Vidyarthi V, Elbazour M, Kunjummen B, Ahmed A, Lubell D. Acute and long-term results after intra-arterial thrombolysis of occluded lower extremity bypass grafts using recombinant tissue plasminogen activator for acute limb-threatening ischemia. Am J Ther. 2003 Jan-Feb; 10 (1):3-6
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Khosla S, Kunjummen B, Khaleel R, Kular R, Gladson M, Razminia M, Guerrero M, Trivedi A, Vidyarthi V, Manda R, Elbazour M, Ahmed A, Lubell D. Safety of therapeutic beta-blockade in patients with coexisting bronchospastic airway disease and coronary artery disease. Am J Ther. 2003 Jan-Feb; 10 (1):48-50
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Khosla S, Kunjummen B, Guerrero M, Manda R, Razminia M, Ahmed A. Suture-mediated closure of antegrade femoral arteriotomy following infrainguinal intervention. Catheter Cardiovasc Interv. 2002 Dec; 57 (4):504-7
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Shui C, Riggs BL, Khosla S. The immunosuppressant rapamycin, alone or with transforming growth factor-beta, enhances osteoclast differentiation of RAW264.7 monocyte-macrophage cells in the presence of RANK-ligand. Calcif Tissue Int. 2002 Nov; 71: (5)437-46.
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Khosla S, Kunjummen B, Guerrero M, Manda R, Razminia M, Trivedi A, Vidyarthi V, Elbazour M, Ahmed A, Lubell D. Safety and efficacy of combined use of low molecular weight heparin (enoxaparin, lovenox) and glycoprotein IIb/IIIa receptor antagonist (eptifibatide, integrelin) during nonemergent coronary and peripheral vascular intervention. Am J Ther. 2002 Nov-Dec; 9 (6):488-91
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Hofbauer LC, Hicok KC, Chen D, Khosla S. Regulation of osteoprotegerin production by androgens and anti-androgens in human osteoblastic lineage cells. European Journal of Endocrinology. 2002 Aug; 147(2):269-73.
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Khosla S, Ballard FJ, Conover CA. Use of site-speciftic antibodies to characterize the circulating form of big insulin-like growth factor II in patients with hepatitis C-associated osteosclerosis. Journal of Clinical Endocrinology & Metabolism. 2002 Aug; 87(8):3867-70.
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Melton LJ 3rd, Achenbach SJ, Melton LJ, O'fallon WM, Khosla S. Secondary osteoporosis and the risk of distal forearm fractures in men and women. Bone. 2002 Jul; 31 (1):119-25
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Riggs BL, Khosla S, Melton LJ. Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev. 2002 Jun; 23 (3):279-302
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Conover CA, Johnstone EW, Turner RT, Evans GL, John Ballard FJ, Doran PM, Khosla S. Subcutaneous administration of insulin-like growth factor (IGF)-II/IGF binding protein-2 complex stimulates bone formation and prevents loss of bone mineral density in a rat model of disuse osteoporosis. Growth Horm IGF Res. 2002 Jun; 12 (3):178-83
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French AR, Mason T, Nelson AM, Crowson CS, O'Fallon WM, Khosla S, Gabriel SE. Osteopenia in adults with a history of juvenile rheumatoid arthritis. A population based study. J Rheumatol. 2002 May; 29(5):1065-70.
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Khosla S, Arrighi HM, Melton LJ 3rd, Melton LJ 3rd, Atkinson EJ, O'Fallon WM, Dunstan C, Riggs BL, Riggs BL. Correlates of osteoprotegerin levels in women and men. Osteoporos Int. 2002 May; 13 (5):394-9
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Rickard DJ, Waters KM, Ruesink TJ, Khosla S, Katzenellenbogen JA, Katzenellenbogen BS, Riggs BL, Spelsberg TC. Estrogen receptor isoform-specific induction of progesterone receptors in human osteoblasts. J Bone Miner Res. 2002 Apr; 17 (4):580-92
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Khosla S, Atkinson EJ, Dunstan CR, O'Fallon WM. Effect of estrogen versus testosterone on circulating osteoprotegerin and other cytokine levels in normal elderly men. J Clin Endocrinol Metab. 2002 Apr; 87 (4):1550-4
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Khosla S, Melton LJ, Riggs BL. Clinical review 144: Estrogen and the male skeleton. J Clin Endocrinol Metab. 2002 Apr; 87 (4):1443-50
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Khosla S. Oestrogen, bones and men: when testosterone just isn't enough. Clin Endocrinol (Oxf). 2002 Mar; 56 (3):291-3
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Heshmati HM, Khosla S, Robins SP, O'Fallon WM, Melton LJ 3rd, Riggs BL. Role of low levels of endogenous estrogen in regulation of bone resorption in late postmenopausal women. J Bone Miner Res. 2002 Jan; 17 (1):172-8
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Khosla S. Minireview: the OPG/RANKL/RANK system. Endocrinology. 2001 Dec; 142 (12):5050-5
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Locklin RM, Riggs BL, Hicok KC, Horton HF, Byrne MC, Khosla S. Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology. J Bone Miner Res. 2001 Dec; 16 (12):2192-204
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Doran PM, Riggs BL, Atkinson EJ, Khosla S. Effects of raloxifene, a selective estrogen receptor modulator, on bone turnover markers and serum sex steroid and lipid levels in elderly men. J Bone Miner Res. 2001 Nov; 16(11):2118-25.
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Khosla S, Melton LJ 3rd, Riggs BL, Melton LJ 3rd, Riggs BL. Estrogens and bone health in men. Calcif Tissue Int. 2001 Oct; 69 (4):189-92
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Waters KM, Rickard DJ, Riggs BL, Riggs BL, Khosla S, Katzenellenbogen JA, Katzenellenbogen BS, Moore J, Moore J, Spelsberg TC. Estrogen regulation of human osteoblast function is determined by the stage of differentiation and the estrogen receptor isoform. J Cell Biochem. 2001 Aug 21-Sep 5; 83 (3):448-62
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Luyer MD, Khosla S, Owen WG, Miller VM. Prospective randomized study of effects of unopposed estrogen replacement therapy on markers of coagulation and inflammation in postmenopausal women. J Clin Endocrinol Metab. 2001 Aug; 86(8):3629-34.
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Burguera B, Hofbauer LC, Thomas T, Gori F, Evans GL, Khosla S, Riggs BL, Turner RT. Leptin reduces ovariectomy-induced bone loss in rats. Endocrinology. 2001 Aug; 142(8):3546-53.
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Yan T, Riggs BL, Boyle WJ, Khosla S. Regulation of osteoclastogenesis and RANK expression by TGF-beta1. J Cell Biochem. 2001 Aug 1-9; 83 (2):320-5
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Khosla S, Melton LJ 3rd, Atkinson EJ, O'Fallon WM. Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men. J Clin Endocrinol Metab. 2001 Aug; 86 (8):3555-61
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Thomas T, Burguera B, Melton LJ 3rd, Melton LJ 3rd, Atkinson EJ, O'Fallon WM, Riggs BL, Riggs BL, Khosla S. Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women. Bone. 2001 Aug; 29 (2):114-20
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Hofbauer LC, Shui C, Riggs BL, Dunstan CR, Spelsberg TC, O'Brien T, Khosla S. Effects of immunosuppressants on receptor activator of NF-kappaB ligand and osteoprotegerin production by human osteoblastic and coronary artery smooth muscle cells. Biochem Biophys Res Commun. 2001 Jan 12; 280(1):334-9.
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Lindor KD, Jorgensen RA, Tiegs RD, Khosla S, Dickson ER. Etidronate for osteoporosis in primary biliary cirrhosis: a randomized trial. J Hepatol. 2000 Dec; 33 (6):878-82
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Gori F, Hofbauer LC, Dunstan CR, Spelsberg TC, Khosla S, Riggs BL. The expression of osteoprotegerin and RANK ligand and the support of osteoclast formation by stromal-osteoblast lineage cells is developmentally regulated. Endocrinology. 2000 Dec; 141 (12):4768-76
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Falahati-Nini A, Riggs BL, Atkinson EJ, O'Fallon WM, Eastell R, Khosla S. Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men. J Clin Invest. 2000 Dec; 106 (12):1553-60
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Melton LJ 3rd, Ardila E, Melton LJ 3rd, Crowson CS, O'Fallon WM, Khosla S. Fractures following thyroidectomy in women: a population-based cohort study. Bone. 2000 Nov; 27 (5):695-700
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Pattanaungkul S, Riggs BL, Yergey AL, Vieira NE, O'Fallon WM, Khosla S. Relationship of intestinal calcium absorption to 1,25-dihydroxyvitamin D [1,25(OH)2D] levels in young versus elderly women: evidence for age-related intestinal resistance to 1,25(OH)2D action. J Clin Endocrinol Metab. 2000 Nov; 85 (11):4023-7
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Thomas T, Burguera B, Melton LJ 3rd, Atkinson EJ, O'Fallon WM, Riggs BL, Khosla S. Relationship of serum leptin levels with body composition and sex steroid and insulin levels in men and women. Metabolism. 2000 Oct; 49(10):1278-84.
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Hefferan TE, Subramaniam M, Khosla S, Riggs BL, Riggs BL, Spelsberg TC. Cytokine-specific induction of the TGF-beta inducible early gene (TIEG): regulation by specific members of the TGF-beta family. J Cell Biochem. 2000 Jun 6; 78 (3):380-90
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Melton LJ 3rd, Khosla S, Crowson CS, O'Connor MK, O'Fallon WM, Riggs BL. Epidemiology of sarcopenia. J Am Geriatr Soc. 2000 Jun; 48(6):625-30.
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Hofbauer LC, Khosla S, Dunstan CR, Lacey DL, Boyle WJ, Riggs BL. The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J Bone Miner Res. 2000 Jan; 15 (1):2-12
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Khosla S. The effects of androgens on osteoblast function in vitro. Mayo Clin Proc. 2000 Jan; 75 Suppl:S51-4.
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Melton LJ 3rd, Khosla S, Riggs BL. Epidemiology of sarcopenia. Mayo Clin Proc. 2000 Jan; 75 Suppl:S10-2; discussion S12-3.
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Riggs BL, Khosla S, Melton LJ 3rd. Primary osteoporosis in men: role of sex steroid deficiency. Mayo Clin Proc. 2000 Jan; 75 Suppl:S46-50.
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Melton LJ 3rd, Melton LJ 3rd, Khosla S, Atkinson EJ, Oconnor MK, Ofallon WM, Oconnor MK, Ofallon WM, Riggs BL, Riggs BL. Cross-sectional versus longitudinal evaluation of bone loss in men and women. Osteoporos Int. 2000; 11 (7):592-9
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Proctor DN, Melton LJ, Melton LJ, Khosla S, Crowson CS, O'Connor MK, Riggs BL, Riggs BL. Relative influence of physical activity, muscle mass and strength on bone density. Osteoporos Int. 2000; 11 (11):944-52
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Melton LJ 3rd, Melton LJ 3rd, Khosla S, Achenbach SJ, O'Connor MK, O'Fallon WM, Riggs BL, Riggs BL. Effects of body size and skeletal site on the estimated prevalence of osteoporosis in women and men. Osteoporos Int. 2000; 11 (11):977-83
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Gori F, Hofbauer LC, Conover CA, Khosla S. Effects of androgens on the insulin-like growth factor system in an androgen-responsive human osteoblastic cell line. Endocrinology. 1999 Dec; 140(12):5579-86.
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Thomas T, Gori F, Spelsberg TC, Khosla S, Riggs BL, Conover CA. Response of bipotential human marrow stromal cells to insulin-like growth factors: effect on binding protein production, proliferation, and commitment to osteoblasts and adipocytes. Endocrinology. 1999 Nov; 140 (11):5036-44
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Hofbauer LC, Gori F, Riggs BL, Lacey DL, Dunstan CR, Spelsberg TC, Khosla S. Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis. Endocrinology. 1999 Oct; 140 (10):4382-9
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Khosla S, Melton LJ 3rd, Wermers RA, Crowson CS, O'Fallon Wm, Riggs BL. Primary hyperparathyroidism and the risk of fracture: a population-based study. J Bone Miner Res. 1999 Oct; 14 (10):1700-7
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Hofbauer LC, Lacey DL, Dunstan CR, Spelsberg TC, Riggs BL, Riggs BL, Khosla S. Interleukin-1beta and tumor necrosis factor-alpha, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells. Bone. 1999 Sep; 25 (3):255-9
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Hofbauer LC, Khosla S, Dunstan CR, Lacey DL, Spelsberg TC, Riggs BL. Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells. Endocrinology. 1999 Sep; 140 (9):4367-70
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Hofbauer LC, Ten RM, Khosla S. The anti-androgen hydroxyflutamide and androgens inhibit interleukin-6 production by an androgen-responsive human osteoblastic cell line. J Bone Miner Res. 1999 Aug; 14(8):1330-7.
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Melton LJ 3rd, Melton LJ 3rd, Crowson CS, Khosla S, O'Fallon WM. Fracture risk after surgery for peptic ulcer disease: a population-based cohort study. Bone. 1999 Jul; 25 (1):61-7
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Spelsberg TC, Subramaniam M, Riggs BL, Khosla S. The actions and interactions of sex steroids and growth factors/cytokines on the skeleton. Mol Endocrinol. 1999 Jun; 13 (6):819-28
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Hofbauer LC, Khosla S. Androgen effects on bone metabolism: recent progress and controversies. Eur J Endocrinol. 1999 Apr; 140 (4):271-86
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Thomas T, Gori F, Khosla S, Jensen MD, Burguera B, Riggs BL. Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes. Endocrinology. 1999 Apr; 140 (4):1630-8
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Colford JW, Lueddecke BA, Salvati M, Hanna D, Sailer D, Khosla S, Riggs BL, Langman CB. Immunoradiometric assay for intact human osteocalcin(1-49) without cross-reactivity to breakdown products. Clin Chem. 1999 Apr; 45(4):526-31.
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Melton LJ 3rd, Atkinson EJ, Khosla S, O'Fallon WM, Riggs BL. Secondary osteoporosis and the risk of vertebral deformities in women. Bone. 1999 Jan; 24 (1):49-55
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Khosla S, Melton LJ 3rd, Riggs BL. Osteoporosis: gender differences and similarities. Lupus. 1999; 8: (5)393-6.
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Hofbauer LC, Hicok KC, Khosla S. Effects of gonadal and adrenal androgens in a novel androgen-responsive human osteoblastic cell line. J Cell Biochem. 1998 Oct 1; 71 (1):96-108
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Hofbauer LC, Dunstan CR, Spelsberg TC, Riggs BL, Khosla S. Osteoprotegerin production by human osteoblast lineage cells is stimulated by vitamin D, bone morphogenetic protein-2, and cytokines. Biochem Biophys Res Commun. 1998 Sep 29; 250(3):776-81.
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Khosla S, Melton LJ 3rd, Atkinson EJ, O'Fallon WM, Klee GG, Riggs BL. Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen. J Clin Endocrinol Metab. 1998 Jul; 83 (7):2266-74
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Heshmati HM, Khosla S, Burritt MF, O'Fallon WM, Riggs BL. A defect in renal calcium conservation may contribute to the pathogenesis of postmenopausal osteoporosis. J Clin Endocrinol Metab. 1998 Jun; 83 (6):1916-20
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Miller P, Lukert B, Broy S, Civitelli R, Fleischmann R, Gagel R, Khosla S, Lucas M, Maricic M, Pacifici R, Recker R, Sarran HS, Short B, Short MJ. Management of postmenopausal osteoporosis for primary care. Menopause. 1998 Summer; 5(2):123-31.
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Khosla S, Hassoun AA, Baker BK, Liu F, Zein NN, Whyte MP, Reasner CA, Nippoldt TB, Tiegs RD, Hintz RL, Conover CA. Insulin-like growth factor system abnormalities in hepatitis C-associated osteosclerosis. Potential insights into increasing bone mass in adults. J Clin Invest. 1998 May 15; 101 (10):2165-73
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Riggs BL, Khosla S, Melton LJ 3rd. A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J Bone Miner Res. 1998 May; 13 (5):763-73
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Heshmati HM, Khosla S. Idiopathic osteoporosis: a heterogeneous entity. Ann Med Interne (Paris). 1998 Mar; 149 (2):77-81
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Heshmati HM, Riggs BL, Burritt MF, McAlister CA, Wollan PC, Khosla S. Effects of the circadian variation in serum cortisol on markers of bone turnover and calcium homeostasis in normal postmenopausal women. J Clin Endocrinol Metab. 1998 Mar; 83(3):751-6.
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Melton LJ 3rd, Crowson CS, Khosla S, Wilson DM, O'Fallon WM. Fracture risk among patients with urolithiasis: a population-based cohort study. Kidney Int. 1998 Feb; 53(2):459-64.
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Wermers RA, Khosla S, Atkinson EJ, Grant CS, Hodgson SF, O'Fallon WM, Melton LJ 3rd, Melton LJ 3rd. Survival after the diagnosis of hyperparathyroidism: a population-based study. Am J Med. 1998 Feb; 104 (2):115-22
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Barry MK, van Heerden JA, Grant CS, Thompson GB, Khosla S. Is familial hyperparathyroidism a unique disease? Surgery. 1997 Dec; 122 (6):1028-33
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Hurley DL, Khosla S. Update on primary osteoporosis. Mayo Clin Proc. 1997 Oct; 72(10):943-9.
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Hofbauer LC, Hicok KC, Schroeder MJ, Harris SA, Robinson JA, Khosla S. Development and characterization of a conditionally immortalized human osteoblastic cell line stably transfected with the human androgen receptor gene. J Cell Biochem. 1997 Sep 15; 66 (4):542-51
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Melton LJ 3rd, Khosla S, Atkinson EJ, O'Fallon WM, Riggs BL. Relationship of bone turnover to bone density and fractures. J Bone Miner Res. 1997 Jul; 12 (7):1083-91
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Hassoun AA, Nippoldt TB, Tiegs RD, Khosla S. Hepatitis C-associated osteosclerosis: an unusual syndrome of acquired osteosclerosis in adults. Am J Med. 1997 Jul; 103 (1):70-3
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McKane WR, Khosla S, Ristela J, Robins SP, Muhs JM, Riggs BL. Role of estrogen deficiency in pathogenesis of secondary hyperparathyroidism and increased bone resorption in elderly women. Obstet Gynecol Surv. 1997 Jul; 52(7):429-431.
Heshmati HM, Gharib H, Khosla S, Abu-Lebdeh HS, Lindor NM, Thibodeau SN. Genetic testing in medullary thyroid carcinoma syndromes: mutation types and clinical significance. Mayo Clin Proc. 1997 May; 72 (5):430-6
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Khosla S, Atkinson EJ, Melton LJ 3rd, Riggs BL. Effects of age and estrogen status on serum parathyroid hormone levels and biochemical markers of bone turnover in women: a population-based study. J Clin Endocrinol Metab. 1997 May; 82 (5):1522-7
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Wermers RA, Khosla S, Atkinson EJ, Hodgson SF, O'Fallon WM, Melton LJ 3rd, Melton LJ 3rd. The rise and fall of primary hyperparathyroidism: a population-based study in Rochester, Minnesota, 1965-1992. Ann Intern Med. 1997 Mar 15; 126 (6):433-40
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McKane WR, Khosla S, Risteli J, Robins SP, Muhs JM, Riggs BL. Role of estrogen deficiency in pathogenesis of secondary hyperparathyroidism and increased bone resorption in elderly women. Proc Assoc Am Physicians. 1997 Mar; 109(2):174-80.
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Khosla S, Atkinson EJ, Riggs BL, Melton LJ 3rd. Relationship between body composition and bone mass in women. J Bone Miner Res. 1996 Jun; 11 (6):857-63
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McKane WR, Khosla S, Egan KS, Robins SP, Burritt MF, Riggs BL. Role of calcium intake in modulating age-related increases in parathyroid function and bone resorption. J Clin Endocrinol Metab. 1996 May; 81(5):1699-703.
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Kassem M, Khosla S, Spelsberg TC, Riggs BL. Cytokine production in the bone marrow microenvironment: failure to demonstrate estrogen regulation in early postmenopausal women. J Clin Endocrinol Metab. 1996 Feb; 81(2):513-8.
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McKane WR, Khosla S, Egan KS, Robins S, Burritt MF, Riggs BL. A high calcium intake reverses the secondary hyperparathyroidism and increased bone resorption of elderly women J Clinical Endocrinol Metab. 1996; 81:1699-703.
Indridason OS, Heath H 3rd, Khosla S, Yohay DA, Quarles LD. Non-suppressible parathyroid hormone secretion is related to gland size in uremia secondary to hyperparathyroidism Kidney International. 1996; 50:1663-71.
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McKane WR, Khosla S, Burritt MF, Kao PC, Wilson DM, Ory SJ, Riggs BL. Mechanism of renal calcium conservation with estrogen replacement therapy in women in early postmenopause--a clinical research center study. J Clin Endocrinol Metab. 1995 Dec; 80(12):3458-64.
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Ledger GA, Burritt MF, Kao PC, O'Fallon WM, Riggs BL, Khosla S. Role of parathyroid hormone in mediating nocturnal and age-related increases in bone resorption. J Clin Endocrinol Metab. 1995 Nov; 80(11):3304-10.
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Khosla S, Riggs BL, Riggs BL. Treatment options for osteoporosis. Mayo Clin Proc. 1995 Oct; 70 (10):978-82
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Riggs BL, Khosla S. Role of biochemical markers in assessment of osteoporosis. Acta Orthop Scand Suppl. 1995 Oct; 266:14-8.
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Khosla S, Hassoun A, Heath H. Osteosclerosis in intravenous drug abusers. Endocrinologist. 1995 Sep; 5:339-343.
Lindor NM, Honchel R, Khosla S, Thibodeau SN. Mutations in the RET protooncogene in sporadic pheochromocytomas. J Clin Endocrinol Metab. 1995 Feb; 80 (2):627-9
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Ledger GA, Khosla S, Lindor NM, Thibodeau SN, Gharib H. Genetic testing in the diagnosis and management of multiple endocrine neoplasia type II. Ann Intern Med. 1995 Jan 15; 122 (2):118-24
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Kane LA, Tsai MS, Gharib H, Khosla S, Robertson DM, Schaid DJ, Honchel R, Thibodeau SN. Familial medullary thyroid cancer and prominent corneal nerves: clinical and genetic analysis. J Clin Endocrinol Metab. 1995 Jan; 80(1):289-93.
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Khosla S, Oursler MJ, Schroeder MJ, Eberhardt NL. Transforming growth factor-beta 1 induces growth inhibition of a human medullary thyroid carcinoma cell line despite an increase in steady state c-myc messenger ribonucleic acid levels. Endocrinology. 1994 Nov; 135(5):1887-93.
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Khosla S, Peterson JM, Egan K, Jones JD, Riggs BL. Circulating cytokine levels in osteoporotic and normal women. J Clin Endocrinol Metab. 1994 Sep; 79(3):707-11.
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Khosla S, Lufkin EG, Hodgson SF, Fitzpatrick LA, Melton LJ 3rd. Epidemiology and clinical features of osteoporosis in young individuals. Bone. 1994 Sep-Oct; 15 (5):551-5
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McKane WR, Khosla S, Peterson JM, Egan K, Riggs BL. Circulating levels of cytokines that modulate bone resorption: effects of age and menopause in women. J Bone Miner Res. 1994 Aug; 9 (8):1313-8
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Ledger GA, Burritt MF, Kao PC, O'Fallon WM, Riggs BL, Khosla S. Abnormalities of parathyroid hormone secretion in elderly women that are reversible by short term therapy with 1,25-dihydroxyvitamin D3. J Clin Endocrinol Metab. 1994 Jul; 79 (1):211-6
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Tsai MS, Ledger GA, Khosla S, Gharib H, Thibodeau SN. Identification of multiple endocrine neoplasia, type 2 gene carriers using linkage analysis and analysis of the RET proto-oncogene. J Clin Endocrinol Metab. 1994 May; 78 (5):1261-4
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McKane WR, Khosla S, Peterson JM, Egan K, Riggs BL. Assessment of circulating levels of cytokines modulating bone resorption: effects of age and menopause in women J Bone Mineral Res. 1994; 9:1313-8.
Khosla S, Oursler MJ, Schroeder MJ, Eberhardt NL. Growth inhibition of a human medullary thyroid carcinoma cell line by transforming growth factor-B1 despite a relative increase in steady state c-myc mRNA levels Endrocrinology. 1994; 135:1887-93.
Farley DR, Eberhardt NL, Grant CS, Schaid DJ, van Heerden JA, Hay ID, Khosla S. Expression of a potential metastasis suppressor gene (nm23) in thyroid neoplasms. World J Surg. 1993 Sep-Oct; 17 (5):615-20; discussion 620-1
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Khosla S, Ebeling PR, Firek AF, Burritt MM, Kao PC, Heath H 3rd. Calcium infusion suggests a "set-point" abnormality of parathyroid gland function in familial benign hypercalcemia and more complex disturbances in primary hyperparathyroidism. J Clin Endocrinol Metab. 1993 Mar; 76(3):715-20.
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Sinaki M, Khosla S, Limburg PJ, Rogers JW, Murtaugh PA. Muscle strength in osteoporotic versus normal women. Osteoporos Int. 1993 Jan; 3 (1):8-12
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Kao PC, van Heerden JA, Grant CS, Klee GG, Khosla S. Clinical performance of parathyroid hormone immunometric assays. Mayo Clin Proc. 1992 Jul; 67 (7):637-45
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Reubi JC, Waser B, Khosla S, Kvols L, Goellner JR, Krenning E, Lamberts S. In vitro and in vivo detection of somatostatin receptors in pheochromocytomas and paragangliomas. J Clin Endocrinol Metab. 1992 May; 74(5):1082-9.
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Khosla S, Patel VM, Hay ID, Schaid DJ, Grant CS, van Heerden JA, Thibodeau SN. Loss of heterozygosity suggests multiple genetic alterations in pheochromocytomas and medullary thyroid carcinomas. J Clin Invest. 1991 May; 87 (5):1691-9
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Khosla S, Johansen KL, Ory SJ, O'Brien PC, Kao PC. Parathyroid hormone-related peptide in lactation and in umbilical cord blood. Mayo Clin Proc. 1990 Nov; 65 (11):1408-14
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Khosla S, Wolfson JS, Demerjian Z, Godine JE. Adrenal crisis in the setting of high-dose ketoconazole therapy. Arch Intern Med. 1989 Apr; 149(4):802-4.
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Khosla S, Demay M, Pines M, Hurwitz S, Potts JT Jr, Kronenberg HM. Nucleotide sequence of cloned cDNAs encoding chicken preproparathyroid hormone. J Bone Miner Res. 1988 Dec; 3(6):689-98.
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Khosla S, Kinter LB, Zusman RM, Beeuwkes R. ACTH and indomethacin induced antidiuresis in low salt Brattleboro rats: induction and escape. Ann N Y Acad Sci. 1982; 394:265-269.
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Fisher J, Belasco JG, Khosla S, Knowles JR. beta-Lactamase proceeds via an acyl-enzyme intermediate. Interaction of the Escherichia coli RTEM enzyme with cefoxitin. Biochemistry. 1980 Jun 24; 19(13):2895-901.
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Fisher J, Belasco JG, Charnas RL, Khosla S, Knowles JR. Beta-lactamase inactivation by mechanism-based reagents. Philos Trans R Soc Lond B Biol Sci. 1980 May 16; 289(1036):309-19.
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Sundeep Khosla, M.D.

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