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The research focus of Eduardo N. Chini, M.D., Ph.D., is in the fields of metabolism, nutrition, obesity, pharmacology, cancer and aging, and kidney disease. In particular, Dr. Chini is interested in nicotinamide adenine dinucleotide (NAD) metabolism and functions. He and his colleagues are exploring the nonoxidative and oxidative roles of NAD (as a signaling molecule and energy coin in cells). Dr. Chini's laboratory has done seminal work on NAD catabolism, including the description of the main enzyme responsible for the degradation of this molecule in mammalian tissues.
SIRT1 function and regulation. The NAD-dependent deacetylase sirtuin-1 (SIRT1) is an enzyme that is involved in several signaling pathways. SIRT1 appears to be a master regulator of aging, metabolism and circadian cycle. SIRT1 has also been implicated as the target for the polyphenolic compound resveratrol and may be implicated in the physiological effects of caloric restriction.
Dr. Chini's team has described for the first time a new crucial enzymatic system, the CD38 pathway, as the main regulator of intracellular NAD levels and SIRT1 activity in vivo. Current work is focusing on this pathway as a possible drug target for the treatment of obesity and metabolic diseases.
The ultimate goal of Dr. Chini's research is to provide new avenues for the development of novel and effective pharmacological therapeutic approaches for human diseases such as obesity, metabolic syndrome, aging-related disease and kidney disease, and their complications, such as autosomal dominant polycystic kidney disease (ADPKD) premature labor.
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