Publications

1. Chini CCS, Cordeiro HS, Tran NLK, Chini EN. NAD metabolism: Role in senescence regulation and aging. Aging Cell. 2024 Jan; 23 (1):e13920 Epub 2023 July 09
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2. Shi B, Amin A, Dalvi P, Wang W, Lukacs N, Kai L, Cheresh P, Peclat TR, Chini CC, Chini EN, van Schooten W, Varga J. Heavy-chain antibody targeting of CD38 NAD+ hydrolase ectoenzyme to prevent fibrosis in multiple organs. Sci Rep. 2023 Dec 12; 13(1):22085.
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3. Bisht K, Fukao T, Chiron M, Richardson P, Atanackovic D, Chini E, Chng WJ, Van De Velde H, Malavasi F. Immunomodulatory properties of CD38 antibodies and their effect on anticancer efficacy in multiple myeloma. Cancer Med. 2023 Oct; 12 (20):20332-20352 Epub 2023 Oct 15
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4. Maita KC, Garcia JP, Avila FR, Torres-Guzman RA, Ho O, Chini CCS, Chini EN, Forte AJ. Evaluation of the Aging Effect on Peripheral Nerve Regeneration: A Systematic Review. J Surg Res. 2023 Aug; 288:329-340 Epub 2023 Apr 14
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5. Abe JI, Imanishi M, Li S, Zhang A, Ko KA, Samanthapudi VSK, Lee LL, Bojorges AP, Gi YJ, Hobbs BP, Deswal A, Herrmann J, Lin SH, Chini EN, Shen YH, Schadler KL, Nguyen TH, Gupte AA, Reyes-Gibby C, Yeung SJ, Abe RJ, Olmsted-Davis EA, Krishnan S, Dantzer R, Palaskas NL, Cooke JP, Pownall HJ, Yoshimoto M, Fujiwara K, Hamilton DJ, Burks JK, Wang G, Le NT, Kotla S. An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis. Circ Res. 2023 Jun 23; 133 (1):25-44 Epub 2023 June 02
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6. Ma X, Zhang Y, Zhang Y, Zhang X, Huang Y, He K, Chen C, Hao J, Zhao D, LeBrasseur NK, Kirkland JL, Chini EN, Wei Q, Ling K, Hu J. A stress-induced cilium-to-PML-NB route drives senescence initiation. Nat Commun. 2023 Apr 3; 14 (1):1840 Epub 2023 Apr 03
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7. Shi B, Tsou PS, Ma F, Mariani MP, Mattichak MN, LeBrasseur NK, Chini EN, Lafyatis R, Khanna D, Whitfield ML, Gudjonsson JE, Varga J. Senescent Cells Accumulate in Systemic Sclerosis Skin. J Invest Dermatol 2023 Apr; 143 (4):661-664.e5 Epub 2022 Sept 30
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8. Englund DA, Jolliffe A, Aversa Z, Zhang X, Sturmlechner I, Sakamoto AE, Zeidler JD, Warner GM, McNinch C, White TA, Chini EN, Baker DJ, van Deursen JM, LeBrasseur NK. p21 induces a senescence program and skeletal muscle dysfunction. Mol Metab. 2023 Jan; 67:101652 Epub 2022 Dec 09
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9. Jain A, Casanova D, Padilla AV, Paniagua Bojorges A, Kotla S, Ko KA, Samanthapudi VSK, Chau K, Nguyen MTH, Wen J, Hernandez Gonzalez SL, Rodgers SP, Olmsted-Davis EA, Hamilton DJ, Reyes-Gibby C, Yeung SJ, Cooke JP, Herrmann J, Chini EN, Xu X, Yusuf SW, Yoshimoto M, Lorenzi PL, Hobbs B, Krishnan S, Koutroumpakis E, Palaskas NL, Wang G, Deswal A, Lin SH, Abe JI, Le NT. Premature senescence and cardiovascular disease following cancer treatments: mechanistic insights. Front Cardiovasc Med. 2023; 10:1212174 Epub 2023 Sept 14
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10. Zeidler JD, Chini CCS, Kanamori KS, Kashyap S, Espindola-Netto JM, Thompson K, Warner G, Cabral FS, Peclat TR, Gomez LS, Lopez SA, Wandersee MK, Schoon RA, Reid K, Menzies K, Beckedorff F, Reid JM, Brachs S, Meyer RG, Meyer-Ficca ML, Chini EN. Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide). iScience. 2022 Nov 18; 25(11):105431. Epub 2022 Oct 23.
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11. Garcia JP, Avila FR, Torres-Guzman RA, Maita KC, Eldaly AS, Palmieri L, Emam O, Chini CC, Chini EN, Forte AJ. Aging increases the risk of flap necrosis in murine models: A systematic review. J Clin Transl Res. 2022 Oct 31; 8 (5):382-389 Epub 2022 Sept 13
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12. Miwa S, Kashyap S, Chini E, von Zglinicki T. Mitochondrial dysfunction in cell senescence and aging. J Clin Invest. 2022 Jul 1; 132 (13)
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13. de Zelicourt A, Fayssoil A, Dakouane-Giudicelli M, De Jesus I, Karoui A, Zarrouki F, Lefebvre F, Mansart A, Launay JM, Piquereau J, Tarrago MG, Bonay M, Forand A, Moog S, Pietri-Rouxel F, Brisebard E, Chini CCS, Kashyap S, Fogarty MJ, Sieck GC, Mericskay M, Chini EN, Gomez AM, Cancela JM, de la Porte S. CD38-NADase is a new major contributor to Duchenne muscular dystrophic phenotype. EMBO Mol Med. 2022 May 9; 14 (5):e12860 Epub 2022 Mar 17
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14. Agorrody G, Peclat TR, Peluso G, Gonano LA, Santos L, van Schooten W, Chini CCS, Escande C, Chini EN, Contreras P. Benefits in cardiac function by CD38 suppression: Improvement in NAD+ levels, exercise capacity, heart rate variability and protection against catecholamine-induced ventricular arrhythmias. J Mol Cell Cardiol. 2022 May; 166:11-22. Epub 2022 Feb 01.
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15. Peclat TR, Thompson KL, Warner GM, Chini CCS, Tarragó MG, Mazdeh DZ, Zhang C, Zavala-Solorio J, Kolumam G, Liang Wong Y, Cohen RL, Chini EN. CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging. Aging Cell. 2022 Apr; 21(4):e13589. Epub 2022 Mar 08.
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16. Zeidler JD, Hogan KA, Agorrody G, Peclat TR, Kashyap S, Kanamori KS, Gomez LS, Mazdeh DZ, Warner GM, Thompson KL, Chini CCS, Chini EN. The CD38 glycohydrolase and the NAD sink: implications for pathological conditions. Am J Physiol Cell Physiol. 2022 Mar 01; 322(3):C521-C545. Epub 2022 Feb 09.
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17. Chini CCS, Peclat TR, Gomez LS, Zeidler JD, Warner GM, Kashyap S, Mazdeh DZ, Hayat F, Migaud ME, Paulus A, Chanan-Khan AA, Chini EN. Dihydronicotinamide Riboside Is a Potent NAD+ Precursor Promoting a Pro-Inflammatory Phenotype in Macrophages. Front Immunol. 2022; 13:840246. Epub 2022 Feb 25.
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18. Zeidler JD, Kashyap S, Hogan KA, Chini EN. Implications of the NADase CD38 in COVID pathophysiology. Physiol Rev. 2022 Jan 1; 102 (1):339-341 Epub 2021 Sept 08
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19. Ugamraj HS, Dang K, Ouisse LH, Buelow B, Chini EN, Castello G, Allison J, Clarke SC, Davison LM, Buelow R, Deng R, Iyer S, Schellenberger U, Manika SN, Bijpuria S, Musnier A, Poupon A, Cuturi MC, van Schooten W, Dalvi P. TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity. MAbs. 2022 Jan-Dec; 14 (1):2095949
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20. Banerjee P, Olmsted-Davis EA, Deswal A, Nguyen MT, Koutroumpakis E, Palaskas NL, Lin SH, Kotla S, Reyes-Gibby C, Yeung SJ, Yusuf SW, Yoshimoto M, Kobayashi M, Yu B, Schadler K, Herrmann J, Cooke JP, Jain A, Chini E, Le NT, Abe JI. Cancer treatment-induced NAD+ depletion in premature senescence and late cardiovascular complications. J Cardiovasc Aging. 2022; 2 Epub 2022 Apr 29
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21. Meyer-Ficca ML, Zwerdling AE, Swanson CA, Tucker AG, Lopez SA, Wandersee MK, Warner GM, Thompson KL, Chini CCS, Chen H, Chini EN, Meyer RG. Low NAD(+) Levels Are Associated With a Decline of Spermatogenesis in Transgenic ANDY and Aging Mice. Front Endocrinol (Lausanne). 2022; 13:896356 Epub 2022 May 06
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22. Imanishi M, Cheng H, Kotla S, Deswal A, Le NT, Chini E, Ko KA, Samanthapudi VSK, Lee LL, Herrmann J, Xu X, Reyes-Gibby C, Yeung SJ, Schadler KL, Yusuf SW, Liao Z, Nurieva R, Amir ED, Burks JK, Palaskas NL, Cooke JP, Lin SH, Kobayashi M, Yoshimoto M, Abe JI. Radiation therapy induces immunosenescence mediated by p90RSK. Front Cardiovasc Med. 2022; 9:988713 Epub 2022 Nov 07
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23. Langley MR, Choi CI, Peclat TR, Guo Y, Simon WL, Yoon H, Kleppe L, Lucchinetti CF, Chini CCS, Chini EN, Scarisbrick IA. Critical Role of Astrocyte NAD+ Glycohydrolase in Myelin Injury and Regeneration. J Neurosci. 2021 Oct 13; 41(41):8644-8667. Epub 2021 Sep 07.
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24. Zhang Y, Hao J, Tarrago MG, Warner GM, Giorgadze N, Wei Q, Huang Y, He K, Chen C, Peclat TR, White TA, Ling K, Tchkonia T, Kirkland JL, Chini EN, Hu J. FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue. Cell Rep. 2021 Aug 03; 36(5):109481.
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25. Kanamori KS, Tarrago MG, Jones A, Cheek EH, Warner GM, Jenkins SM, Povero D, Graham RP, Mounajjed T, Chedid MF, Sabat BD, Torbenson MS, Heimbach JK, Chini EN, Moreira RK. Surface color spectrophotometry in a murine model of steatosis: an accurate technique with potential applicability in liver procurement. Lab Invest. 2021 Aug; 101 (8):1098-1109 Epub 2021 Apr 15
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26. Kanamori KS, Tarrago MG, Jones A, Cheek EH, Warner GM, Jenkins SM, Povero D, Graham RP, Mounajjed T, Chedid MF, Sabat BD, Torbenson MS, Heimbach JK, Chini EN, Moreira RK. Surface color spectrophotometry in a murine model of steatosis: an accurate technique with potential applicability in liver procurement. Lab Invest. 2021 Aug; 101 (8):1098-1109 Epub 2023 Jan 04
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27. Chini CCS, Zeidler JD, Kashyap S, Warner G, Chini EN. Evolving concepts in NAD(+) metabolism. Cell Metab. 2021 Jun 1; 33 (6):1076-1087 Epub 2021 Apr 29
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28. Ramalingam H, Kashyap S, Cobo-Stark P, Flaten A, Chang CM, Hajarnis S, Hein KZ, Lika J, Warner GM, Espindola-Netto JM, Kumar A, Kanchwala M, Xing C, Chini EN, Patel V. A methionine-Mettl3-N(6)-methyladenosine axis promotes polycystic kidney disease. Cell Metab. 2021 Jun 1; 33 (6):1234-1247.e7 Epub 2021 Apr 13
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29. Shi B, Wang W, Korman B, Kai L, Wang Q, Wei J, Bale S, Marangoni RG, Bhattacharyya S, Miller S, Xu D, Akbarpour M, Cheresh P, Proccissi D, Gursel D, Espindola-Netto JM, Chini CCS, de Oliveira GC, Gudjonsson JE, Chini EN, Varga J. Targeting CD38-dependent NAD(+) metabolism to mitigate multiple organ fibrosis. iScience. 2021 Jan 22; 24 (1):101902 Epub 2020 Dec 07
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30. Hayashi Y, Asuzu DT, Bardsley MR, Gajdos GB, Kvasha SM, Linden DR, Nagy RA, Saravanaperumal SA, Syed SA, Toyomasu Y, Yan H, Chini EN, Gibbons SJ, Kellogg TA, Khazaie K, Kuro-O M, Machado Espindola Netto J, Singh MP, Tidball JG, Wehling-Henricks M, Farrugia G, Ordog T. Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During Aging. Cell Mol Gastroenterol Hepatol. 2021; 11 (1):117-145 Epub 2020 Aug 07
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31. Goplen NP, Wu Y, Son YM, Li C, Wang Z, Cheon IS, Jiang L, Zhu B, Ayasoufi K, Chini EN, Johnson AJ, Vassallo R, Limper AH, Zhang N, Sun J. Tissue-resident CD8(+) T cells drive age-associated chronic lung sequelae after viral pneumonia. Sci Immunol. 2020 Nov 6; 5 (53)
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32. Peclat TR, Shi B, Varga J, Chini EN. The NADase enzyme CD38: an emerging pharmacological target for systemic sclerosis, systemic lupus erythematosus and rheumatoid arthritis. Curr Opin Rheumatol. 2020 Nov; 32 (6):488-496
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33. Chini CCS, Peclat TR, Warner GM, Kashyap S, Espindola-Netto JM, de Oliveira GC, Gomez LS, Hogan KA, Tarrago MG, Puranik AS, Agorrody G, Thompson KL, Dang K, Clarke S, Childs BG, Kanamori KS, Witte MA, Vidal P, Kirkland AL, De Cecco M, Chellappa K, McReynolds MR, Jankowski C, Tchkonia T, Kirkland JL, Sedivy JM, van Deursen JM, Baker DJ, van Schooten W, Rabinowitz JD, Baur JA, Chini EN. CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD(+) and NMN levels. Nat Metab. 2020 Nov; 2 (11):1284-1304 Epub 2020 Nov 16
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34. Kashyap S, Zeidler JD, Chini CCS, Chini EN. Implications of the PAPP-A-IGFBP-IGF-1 pathway in the pathogenesis and treatment of polycystic kidney disease. Cell Signal. 2020 Sep; 73:109698 Epub 2020 June 20
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35. Chini EN. Of Mice and Men: NAD(+) Boosting with Niacin Provides Hope for Mitochondrial Myopathy Patients. Cell Metab 2020 Jun 2; 31 (6):1041-1043
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36. Manna A, Kellett T, Aulakh S, Lewis-Tuffin LJ, Dutta N, Knutson K, Chini E, Pinilla-Ibarz J, Lamanna N, Manochakian R, Malavasi F, Sher T, Chanan-Khan AA, Ailawadhi S, Paulus A. Targeting CD38 is lethal to Breg-like chronic lymphocytic leukemia cells and Tregs, but restores CD8+ T-cell responses. Blood Adv. 2020 May 26; 4 (10):2143-2157
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37. Kashyap S, Hein KZ, Chini CC, Lika J, Warner GM, Bale LK, Torres VE, Harris PC, Oxvig C, Conover CA, Chini EN. Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis. JCI Insight. 2020 Feb 27; 5 (4)
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38. Santos L, Colman L, Contreras P, Chini CC, Carlomagno A, Leyva A, Bresque M, Marmisolle I, Quijano C, Duran R, Irigoin F, Prieto-Echague V, Vendelbo MH, Sotelo-Silveira JR, Chini EN, Badano JL, Calliari AJ, Escande C. A novel form of Deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo. Sci Rep. 2019 Oct 7; 9 (1):14381 Epub 2019 Oct 07
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39. Manna A, Aulakh S, Jani P, Ahmed S, Akhtar S, Coignet M, Heckman M, Meghji Z, Bhatia K, Sharma A, Sher T, Alegria V, Malavasi F, Chini EN, Chanan-Khan A, Ailawadhi S, Paulus A. Targeting CD38 Enhances the Antileukemic Activity of Ibrutinib in Chronic Lymphocytic Leukemia. Clin Cancer Res. 2019 Jul 1; 25 (13):3974-3985 Epub 2019 Apr 02
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40. Kanamori KS, de Oliveira GC, Auxiliadora-Martins M, Schoon RA, Reid JM, Chini EN. Erratum: Correction Notice: Two Different Methods of Quantification of Oxidized Nicotinamide Adenine Dinucleotide (NAD(+)) and Reduced Nicotinamide Adenine Dinucleotide (NADH) Intracellular Levels: Enzymatic Coupled Cycling Assay and Ultra-performance Liquid Chromatography (UPLC)-Mass Spectrometry. Bio Protoc. 2019 Jun 5; 9 (11) Epub 2019 June 05
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41. Palmer AK, Xu M, Zhu Y, Pirtskhalava T, Weivoda MM, Hachfeld CM, Prata LG, van Dijk TH, Verkade E, Casaclang-Verzosa G, Johnson KO, Cubro H, Doornebal EJ, Ogrodnik M, Jurk D, Jensen MD, Chini EN, Miller JD, Matveyenko A, Stout MB, Schafer MJ, White TA, Hickson LJ, Demaria M, Garovic V, Grande J, Arriaga EA, Kuipers F, von Zglinicki T, LeBrasseur NK, Campisi J, Tchkonia T, Kirkland JL. Targeting senescent cells alleviates obesity-induced metabolic dysfunction. Aging Cell. 2019 Jun; 18 (3):e12950 Epub 2019 Mar 25
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42. Chini C, Hogan KA, Warner GM, Tarragó MG, Peclat TR, Tchkonia T, Kirkland JL, Chini E. The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline. Biochem Biophys Res Commun. 2019 May 28; 513(2):486-493. Epub 2019 Apr 08.
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43. de Oliveira GC, Kanamori KS, Auxiliadora-Martins M, Chini CCS, Chini EN. Erratum: Correction Notice: Measuring CD38 Hydrolase and Cyclase Activities: 1,N6-Ethenonicotinamide Adenine Dinucleotide (epsilon-NAD) and Nicotinamide Guanine Dinucleotide (NGD) Fluorescence-based Methods. Bio Protoc. 2019 May 5; 9 (9) Epub 2019 May 05
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44. Hogan KA, Chini CCS, Chini EN. The Multi-faceted Ecto-enzyme CD38: Roles in Immunomodulation, Cancer, Aging, and Metabolic Diseases. Front Immunol. 2019; 10:1187 Epub 2019 May 31
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45. Kanamori KS, de Oliveira GC, Auxiliadora-Martins M, Schoon RA, Reid JM, Chini EN. Two Different Methods of Quantification of Oxidized Nicotinamide Adenine Dinucleotide (NAD(+)) and Reduced Nicotinamide Adenine Dinucleotide (NADH) Intracellular Levels: Enzymatic Coupled Cycling Assay and Ultra-performance Liquid Chromatography (UPLC)-Mass Spectrometry. Bio Protoc. 2018 Jul 20; 8 (14)
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46. de Oliveira GC, Kanamori KS, Auxiliadora-Martins M, Chini CCS, Chini EN. Measuring CD38 Hydrolase and Cyclase Activities: 1,N(6)-Ethenonicotinamide Adenine Dinucleotide (epsilon-NAD) and Nicotinamide Guanine Dinucleotide (NGD) Fluorescence-based Methods. Bio Protoc. 2018 Jul 20; 8 (14)
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47. Boslett J, Helal M, Chini E, Zweier JL. Genetic deletion of CD38 confers post-ischemic myocardial protection through preserved pyridine nucleotides. J Mol Cell Cardiol. 2018 May; 118:81-94 Epub 2018 Feb 21
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48. Chini EN, Chini CCS, Espindola Netto JM, de Oliveira GC, van Schooten W. The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging. Trends Pharmacol Sci. 2018 Apr; 39 (4):424-436 Epub 2018 Feb 23
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49. Chaker M, Minden A, Chen S, Weiss RH, Chini EN, Mahipal A, Azmi AS. Rho GTPase effectors and NAD metabolism in cancer immune suppression. Expert Opin Ther Targets. 2018 Jan; 22 (1):9-17 Epub 2017 Dec 10
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50. Chini CCS, Tarrago MG, Chini EN. NAD and the aging process: Role in life, death and everything in between. Mol Cell Endocrinol. 2017 Nov 5; 455:62-74 Epub 2016 Nov 05
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51. Espindola-Netto JM, Chini CCS, Tarragó M, Wang E, Dutta S, Pal K, Mukhopadhyay D, Sola-Penna M, Chini EN. Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer. Oncotarget. 2017 Oct 17; 8(49):85054-85067. Epub 2017 Jun 29.
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52. Matalonga J, Glaria E, Bresque M, Escande C, Carbo JM, Kiefer K, Vicente R, Leon TE, Beceiro S, Pascual-Garcia M, Serret J, Sanjurjo L, Moron-Ros S, Riera A, Paytubi S, Juarez A, Sotillo F, Lindbom L, Caelles C, Sarrias MR, Sancho J, Castrillo A, Chini EN, Valledor AF. The Nuclear Receptor LXR Limits Bacterial Infection of Host Macrophages through a Mechanism that Impacts Cellular NAD Metabolism. Cell Rep. 2017 Jan 31; 18 (5):1241-1255
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53. Li F, Wang P, Liu K, Tarrago MG, Lu J, Chini EN, Ma X. A High Dose of Isoniazid Disturbs Endobiotic Homeostasis in Mouse Liver. Drug Metab Dispos. 2016 Nov; 44 (11):1742-1751 Epub 2016 Aug 16
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54. Camacho-Pereira J, Tarrago MG, Chini CCS, Nin V, Escande C, Warner GM, Puranik AS, Schoon RA, Reid JM, Galina A, Chini EN. CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. Cell Metab. 2016 Jun 14; 23 (6):1127-1139
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55. Chini CC, Espindola-Netto JM, Mondal G, Guerrico AM, Nin V, Escande C, Sola-Penna M, Zhang JS, Billadeau DD, Chini EN. SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway. Clin Cancer Res. 2016 May 15; 22 (10):2496-507 Epub 2015 Dec 11
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56. Warner G, Hein KZ, Nin V, Edwards M, Chini CC, Hopp K, Harris PC, Torres VE, Chini EN. Food Restriction Ameliorates the Development of Polycystic Kidney Disease. J Am Soc Nephrol. 2016 May; 27 (5):1437-47 Epub 2015 Nov 04
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57. Tulino R, Benjamin AC, Jolinon N, Smith DL, Chini EN, Carnemolla A, Bates GP. SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington's Disease Mice. PLoS One. 2016; 11 (1):e0145425 Epub 2016 Jan 27
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58. Mondal S, Roy D, Camacho-Pereira J, Khurana A, Chini E, Yang L, Baddour J, Stilles K, Padmabandu S, Leung S, Kalloger S, Gilks B, Lowe V, Dierks T, Hammond E, Dredge K, Nagrath D, Shridhar V. HSulf-1 deficiency dictates a metabolic reprograming of glycolysis and TCA cycle in ovarian cancer. Oncotarget. 2015 Oct 20; 6 (32):33705-19
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59. Kong S, Dong H, Song J, Thiruppathi M, Prabhakar BS, Qiu Q, Lin Z, Chini E, Zhang B, Fang D. Deleted in Breast Cancer 1 Suppresses B Cell Activation through RelB and Is Regulated by IKKalpha Phosphorylation. J Immunol. 2015 Oct 15; 195 (8):3685-93 Epub 2015 Sept 16
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60. Mathison A, Escande C, Calvo E, Seo S, White T, Salmonson A, Faubion WA Jr, Buttar N, Iovanna J, Lomberk G, Chini EN, Urrutia R. Phenotypic Characterization of Mice Carrying Homozygous Deletion of KLF11, a Gene in Which Mutations Cause Human Neonatal and MODY VII Diabetes. Endocrinology. 2015 Oct; 156 (10):3581-95 Epub 2015 Aug 06
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61. Palmer AK, Tchkonia T, LeBrasseur NK, Chini EN, Xu M, Kirkland JL. Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity. Diabetes. 2015 Jul; 64 (7):2289-98
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62. Wang Y, Cao Y, Yamada S, Thirunavukkarasu M, Nin V, Joshi M, Rishi MT, Bhattacharya S, Camacho-Pereira J, Sharma AK, Shameer K, Kocher JP, Sanchez JA, Wang E, Hoeppner LH, Dutta SK, Leof EB, Shah V, Claffey KP, Chini EN, Simons M, Terzic A, Maulik N, Mukhopadhyay D. Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-alpha Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1alpha and Mitochondrial Homeostasis. Arterioscler Thromb Vasc Biol. 2015 Jun; 35 (6):1401-12 Epub 2015 Apr 16
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63. Escande C, Nin V, Pirtskhalava T, Chini CC, Tchkonia T, Kirkland JL, Chini EN. Deleted in breast cancer 1 limits adipose tissue fat accumulation and plays a key role in the development of metabolic syndrome phenotype. Diabetes. 2015 Jan; 64 (1):12-22 Epub 2014 July 22
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64. Clasen BF, Poulsen MM, Escande C, Pedersen SB, Moller N, Chini EN, Jessen N, Jorgensen JO. Growth hormone signaling in muscle and adipose tissue of obese human subjects: associations with measures of body composition and interaction with resveratrol treatment. J Clin Endocrinol Metab. 2014 Dec; 99 (12):E2565-73
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65. Kong S, Thiruppathi M, Qiu Q, Lin Z, Dong H, Chini EN, Prabhakar BS, Fang D. DBC1 is a suppressor of B cell activation by negatively regulating alternative NF-kappaB transcriptional activity. J Immunol. 2014 Dec 1; 193 (11):5515-24 Epub 2014 Oct 31
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66. Escande C, Nin V, Pirtskhalava T, Chini CC, Thereza Barbosa M, Mathison A, Urrutia R, Tchkonia T, Kirkland JL, Chini EN. Deleted in Breast Cancer 1 regulates cellular senescence during obesity. Aging Cell. 2014 Oct; 13 (5):951-3 Epub 2014 July 03
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67. Nin V, Chini CC, Escande C, Capellini V, Chini EN. Deleted in breast cancer 1 (DBC1) protein regulates hepatic gluconeogenesis. J Biol Chem. 2014 Feb 28; 289 (9):5518-27 Epub 2014 Jan 10
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68. Roy D, Mondal S, Wang C, He X, Khurana A, Giri S, Hoffmann R, Jung DB, Kim SH, Chini EN, Periera JC, Folmes CD, Mariani A, Dowdy SC, Bakkum-Gamez JN, Riska SM, Oberg AL, Karoly ED, Bell LN, Chien J, Shridhar V. Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014; 2:24 Epub 2014 Nov 04
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69. Roy D, Mondal S, Wang C, He X, Khurana A, Giri S, Hoffmann R, Jung DB, Kim SH, Chini EN, Periera JC, Folmes CD, Mariani A, Dowdy SC, Bakkum-Gamez JN, Riska SM, Oberg AL, Karoly ED, Bell LN, Chien J, Shridhar V. Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014; 2:13 Epub 2014 Aug 18
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70. Calliari A, Bobba N, Escande C, Chini EN. Resveratrol delays Wallerian degeneration in a NAD(+) and DBC1 dependent manner. Exp Neurol. 2014 Jan; 251:91-100 Epub 2013 Nov 16
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71. Chini CC, Guerrico AM, Nin V, Camacho-Pereira J, Escande C, Barbosa MT, Chini EN. Targeting of NAD metabolism in pancreatic cancer cells: potential novel therapy for pancreatic tumors. Clin Cancer Res. 2014 Jan 1; 20 (1):120-30 Epub 2013 Sept 11
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72. Chini EN, Chini CC, Nin V, Escande C. Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer. Biosci Rep. 2013 Aug 23; 33 (4)
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73. Lomberk G, Grzenda A, Mathison A, Escande C, Zhang JS, Calvo E, Miller LJ, Iovanna J, Chini EN, Fernandez-Zapico ME, Urrutia R. Kruppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young. J Biol Chem. 2013 Jun 14; 288 (24):17745-58 Epub 2013 Apr 15
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74. Chini CC, Escande C, Nin V, Chini EN. DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbalpha. Biochem J. 2013 May 1; 451 (3):453-61
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75. Escande C, Nin V, Price NL, Capellini V, Gomes AP, Barbosa MT, O'Neil L, White TA, Sinclair DA, Chini EN. Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes. 2013 Apr; 62 (4):1084-93 Epub 2012 Nov 19
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76. Nin V, Escande C, Chini CC, Giri S, Camacho-Pereira J, Matalonga J, Lou Z, Chini EN. Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase. J Biol Chem. 2012 Jul 6; 287 (28):23489-501 Epub 2012 May 02
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77. Sahar S, Nin V, Barbosa MT, Chini EN, Sassone-Corsi P. Altered behavioral and metabolic circadian rhythms in mice with disrupted NAD+ oscillation. Aging (Albany NY). 2011 Aug; 3(8):794-802.
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78. Aksoy P, Brown MJ, Chini EN. HMG-CoA reductase inhibitors decrease hyperglycemia on animal model of Systemic inflammatory response Syndrome (SIRS). Journal of Anesthesia and Clinical Research. 2011; 2(9):165.
    
79. Chini CC, Escande C, Nin V, Chini EN. HDAC3 is negatively regulated by the nuclear protein DBC1. J Biol Chem. 2010 Dec 24; 285 (52):40830-7 Epub 2010 Oct 28
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80. Novak CM, Escande C, Burghardt PR, Zhang M, Barbosa MT, Chini EN, Britton SL, Koch LG, Akil H, Levine JA. Spontaneous activity, economy of activity, and resistance to diet-induced obesity in rats bred for high intrinsic aerobic capacity. Horm Behav. 2010 Aug; 58(3):355-67. Epub 2010 Mar 27.
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81. Hartman WR, Pelleymounter LL, Moon I, Kalari K, Liu M, Wu TY, Escande C, Nin V, Chini EN, Weinshilboum RM. CD38 expression, function, and gene resequencing in a human lymphoblastoid cell line-based model system. Leuk Lymphoma. 2010 Jul; 51 (7):1315-25
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82. Escande C, Chini CC, Nin V, Dykhouse KM, Novak CM, Levine J, van Deursen J, Gores GJ, Chen J, Lou Z, Chini EN. Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. J Clin Invest. 2010 Feb; 120 (2):545-58 Epub 2010 Jan 11
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83. Novak CM, Escande C, Gerber SM, Chini EN, Zhang M, Britton SL, Koch LG, Levine JA. Endurance capacity, not body size, determines physical activity levels: role of skeletal muscle PEPCK. PLoS One. 2009 Jun 12; 4 (6):e5869 Epub 2009 June 12
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84. Chini EN. CD38 as a regulator of cellular NAD: a novel potential pharmacological target for metabolic conditions. Curr Pharm Des. 2009; 15 (1):57-63
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85. Nagamune K, Hicks LM, Fux B, Brossier F, Chini EN, Sibley LD. Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii. Nature. 2008 Jan 10; 451(7175):207-10.
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86. Nagamune K, Moreno SN, Chini EN, Sibley LD. Calcium regulation and signaling in apicomplexan parasites. Subcell Biochem. 2008; 47:70-81.
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87. Barbosa MT, Soares SM, Novak CM, Sinclair D, Levine JA, Aksoy P, Chini EN. The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity. FASEB J. 2007 Nov; 21(13):3629-39. Epub 2007 Jun 21.
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88. Perkins WJ, Taniguchi M, Warner DO, Chini EN, Jones KA. Reduction in soluble guanylyl cyclase-specific activity following prolonged treatment of porcine pulmonary artery with nitric oxide. Am J Physiol Lung Cell Mol Physiol. 2007 Jul; 293 (1):L84-95 Epub 2007 Mar 23
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89. Soares S, Thompson M, White T, Isbell A, Yamasaki M, Prakash Y, Lund FE, Galione A, Chini EN. NAADP as a second messenger: neither CD38 nor base-exchange reaction are necessary for in vivo generation of NAADP in myometrial cells. Am J Physiol Cell Physiol. 2007 Jan; 292 (1):C227-39 Epub 2006 June 21
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90. Umesh A, Thompson MA, Chini EN, Yip KP, Sham JS. Integrin ligands mobilize Ca2+ from ryanodine receptor-gated stores and lysosome-related acidic organelles in pulmonary arterial smooth muscle cells. J Biol Chem. 2006 Nov 10; 281(45):34312-23. Epub 2006 Sep 09.
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91. Aksoy P, Escande C, White TA, Thompson M, Soares S, Benech JC, Chini EN. Regulation of SIRT 1 mediated NAD dependent deacetylation: a novel role for the multifunctional enzyme CD38. Biochem Biophys Res Commun. 2006 Oct 13; 349 (1):353-9 Epub 2006 Aug 22
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92. Kip SN, Smelter M, Iyanoye A, Chini EN, Prakash YS, Pabelick CM, Sieck GC. Agonist-induced cyclic ADP ribose production in airway smooth muscle. Arch Biochem Biophys. 2006 Aug 15; 452(2):102-7. Epub 2006 Jun 30.
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93. Nakayama T, Penheiter AR, Penheiter SG, Chini EN, Thompson M, Warner DO, Jones KA. Differential effects of volatile anesthetics on M3 muscarinic receptor coupling to the Galphaq heterotrimeric G protein. Anesthesiology. 2006 Aug; 105 (2):313-24
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94. White TA, Xue A, Chini EN, Thompson M, Sieck GC, Wylam ME. Role of transient receptor potential C3 in TNF-alpha-enhanced calcium influx in human airway myocytes. Am J Respir Cell Mol Biol. 2006 Aug; 35 (2):243-51 Epub 2006 Mar 30
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95. Aksoy P, White TA, Thompson M, Chini EN. Regulation of intracellular levels of NAD: a novel role for CD38. Biochem Biophys Res Commun. 2006 Jul 14; 345 (4):1386-92 Epub 2006 May 15
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96. Thompson M, White T, Chini EN. Modulation of store-operated Ca2+ entry by cyclic-ADP-ribose. Braz J Med Biol Res. 2006 Jun; 39 (6):739-48 Epub 2006 June 02
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97. Chini EN, Nagamune K, Wetzel DM, Sibley LD. Evidence that the cADPR signalling pathway controls calcium-mediated microneme secretion in Toxoplasma gondii. Biochem J. 2005 Jul 15; 389 (Pt 2):269-77
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98. Sen S, Chini EN, Brown MJ. Complications after unintentional intra-arterial injection of drugs: risks, outcomes, and management strategies. Mayo Clin Proc. 2005 Jun; 80 (6):783-95
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99. Soares SM, Thompson M, Chini EN. Role of the second-messenger cyclic-adenosine 5'-diphosphate-ribose on adrenocorticotropin secretion from pituitary cells. Endocrinology. 2005 May; 146 (5):2186-92 Epub 2005 Feb 17
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100. Burrow B, Burkle C, Warner DO, Chini EN. Postoperative outcome of patients with narcolepsy. A retrospective analysis. J Clin Anesth. 2005 Feb; 17(1):21-5.
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101. Thompson M, Barata da Silva H, Zielinska W, White TA, Bailey JP, Lund FE, Sieck GC, Chini EN. Role of CD38 in myometrial Ca2+ transients: modulation by progesterone. Am J Physiol Endocrinol Metab. 2004 Dec; 287 (6):E1142-8 Epub 2004 Aug 31
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102. Chini EN, Brown MJ, Farrell MA, Charboneau JW. Hypertensive crisis in a patient undergoing percutaneous radiofrequency ablation of an adrenal mass under general anesthesia. Anesth Analg. 2004 Dec; 99 (6):1867-1869
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103. Zielinska W, Barata H, Chini EN. Metabolism of cyclic ADP-ribose: Zinc is an endogenous modulator of the cyclase/NAD glycohydrolase ratio of a CD38-like enzyme from human seminal fluid. Life Sci. 2004 Feb 20; 74 (14):1781-90
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104. Barata H, Thompson M, Zielinska W, Han YS, Mantilla CB, Prakash YS, Feitoza S, Sieck G, Chini EN. The role of cyclic-ADP-ribose-signaling pathway in oxytocin-induced Ca2+ transients in human myometrium cells. Endocrinology. 2004 Feb; 145 (2):881-9 Epub 2003 Oct 16
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105. Chini EN. To be or not to be ... nicotinic acid adenine dinucleotide phosphate (NAADP): a new intracellular second messenger? Biol Res. 2004; 37 (4):559-63
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106. Chini EN, Chini CC, Barata da Silva H, Zielinska W. The cyclic-ADP-ribose signaling pathway in human myometrium. Arch Biochem Biophys. 2002 Nov 15; 407 (2):152-9
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107. Chini EN, Keller TF, Prakash YS, Pabelick CM, Sieck G. Effect of halothane on cADP-ribose-induced Ca(2+) release system in tracheal smooth muscle. Anesthesiology. 2002 Oct; 97 (4):1022-4
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108. Chini EN, De Toledo FG. Nicotinic acid adenine dinucleotide phosphate: a new intracellular second messenger? Am J Physiol Cell Physiol. 2002 Jun; 282 (6):C1191-8
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109. Chini EN. Interactions between intracellular Ca2+ stores: Ca2+ released from the NAADP pool potentiates cADPR-induced Ca2+ release. Braz J Med Biol Res. 2002 May; 35 (5):543-7
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110. Chini EN, Chini CC, Kato I, Takasawa S, Okamoto H. CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues. Biochem J. 2002 Feb 15; 362 (Pt 1):125-30
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111. Chini EN. Selected contribution: effect of volatile anesthetics on cADP-ribose-induced Ca(2+) release system. J Appl Physiol (1985). 2001 Jul; 91 (1):516-21; discussion 504-5
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112. Yusufi AN, Cheng J, Thompson MA, Chini EN, Grande JP. Nicotinic acid-adenine dinucleotide phosphate (NAADP) elicits specific microsomal Ca2+ release from mammalian cells. Biochem J. 2001 Feb 1; 353 (Pt 3):531-6
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113. Cheng J, Yusufi ANK, Thompson MA, Chini EN, Grande JP. Nicotinic acid adenine dinucleotide phosphate: a new Ca2+ releasing agent in kidney. J Am Soc Nephrol. 2001 Jan; 12 (1):54-60
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114. de Toledo FG, Cheng J, Liang M, Chini EN, Dousa TP. ADP-Ribosyl cyclase in rat vascular smooth muscle cells: properties and regulation. Circ Res. 2000 Jun 9; 86 (11):1153-9
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115. Chini EN, Walker H. FK506 (tacrolimus) increases halothane-induced Ca2+ release from skeletal muscle sarcoplasmic reticulum. Anesthesiology. 2000 May; 92 (5):1361-5
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116. Liang M, Chini EN, Cheng J, Dousa TP. Synthesis of NAADP and cADPR in mitochondria. Arch Biochem Biophys. 1999 Nov 15; 371 (2):317-25
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117. Caride AJ, Chini EN, Penniston JT, Dousa TP. Selective decrease of mRNAs encoding plasma membrane calcium pump isoforms 2 and 3 in rat kidney. Kidney Int. 1999 Nov; 56 (5):1818-25
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118. Chini EN, Dousa TP. Differential effect of glycolytic intermediaries upon cyclic ADP-ribose-, inositol 1',4',5'-trisphosphate-, and nicotinate adenine dinucleotide phosphate-induced Ca(2+) release systems. Arch Biochem Biophys. 1999 Oct 15; 370(2):294-9.
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119. Chini EN, Liang M, Dousa TP. Differential effect of pH upon cyclic-ADP-ribose and nicotinate-adenine dinucleotide phosphate-induced Ca2+ release systems. Biochem J. 1998 Nov 1; 335 ( Pt 3):499-504
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120. Caride AJ, Chini EN, Homma S, Penniston JT, Dousa TP. mRNA encoding four isoforms of the plasma membrane calcium pump and their variants in rat kidney and nephron segments. J Lab Clin Med. 1998 Aug; 132 (2):149-56
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121. Caride AJ, Chini EN, Homma S, Dousa TP, Penniston JT. mRNAs coding for the calcium-sensing receptor along the rat nephron: effect of a low-phosphate diet. Kidney Blood Press Res. 1998; 21 (5):305-9
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122. Chini EN, Chini CC, Bolliger C, Jougasaki M, Grande JP, Burnett JC Jr, Dousa TP. Cytoprotective effects of adrenomedullin in glomerular cell injury: central role of cAMP signaling pathway. Kidney Int. 1997 Oct; 52 (4):917-25
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123. Chini EN, de Toledo FG, Thompson MA, Dousa TP. Effect of estrogen upon cyclic ADP ribose metabolism: beta-estradiol stimulates ADP ribosyl cyclase in rat uterus. Proc Natl Acad Sci U S A. 1997 May 27; 94 (11):5872-6
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124. Chini EN, Klener P Jr, Beers KW, Chini CC, Grande JP, Dousa TP. Cyclic ADP-ribose metabolism in rat kidney: high capacity for synthesis in glomeruli. Kidney Int. 1997 May; 51 (5):1500-6
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125. Chini CC, Grande JP, Chini EN, Dousa TP. Compartmentalization of cAMP signaling in mesangial cells by phosphodiesterase isozymes PDE3 and PDE4. Regulation of superoxidation and mitogenesis. J Biol Chem. 1997 Apr 11; 272(15):9854-9.
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126. Chini EN, Thompson MA, Chini CC, Dousa TP. Cyclic ADP-ribose signaling in sea urchin gametes: metabolism in spermatozoa. Am J Physiol. 1997 Feb; 272 (2 Pt 1):C416-20
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127. Dousa TP, Chini EN, Beers KW. Adenine nucleotide diphosphates: emerging second messengers acting via intracellular Ca2+ release. Am J Physiol. 1996 Oct; 271 (4 Pt 1):C1007-24
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128. Chini EN, Dousa TP. Nicotinate-adenine dinucleotide phosphate-induced Ca(2+)-release does not behave as a Ca(2+)-induced Ca(2+)-release system. Biochem J. 1996 Jun 15; 316 ( Pt 3):709-11
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129. Beers KW, Thompson MA, Chini EN, Dousa TP. beta-Estradiol inhibits Na+-P(i) cotransport across renal brush border membranes from ovariectomized rats. Biochem Biophys Res Commun. 1996 Apr 16; 221(2):442-5.
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130. Chini EN, Dousa TP. Palmitoyl-CoA potentiates the Ca2+ release elicited by cyclic ADP-ribose. Am J Physiol. 1996 Feb; 270 (2 Pt 1):C530-7
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131. Perez-Terzic CM, Chini EN, Shen SS, Dousa TP, Clapham DE. Ca2+ release triggered by nicotinate adenine dinucleotide phosphate in intact sea urchin eggs. Biochem J. 1995 Dec 15; 312 ( Pt 3):955-9
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132. Caride AJ, Chini EN, Yamaki M, Dousa TP, Penniston JT. Unique localization of mRNA encoding plasma membrane Ca2+ pump isoform 3 in rat thin descending loop of Henle. Am J Physiol. 1995 Nov; 269 (5 Pt 2):F681-5
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133. Chini EN, Choi E, Grande JP, Burnett JC, Dousa TP. Adrenomedullin suppresses mitogenesis in rat mesangial cells via cAMP pathway. Biochem Biophys Res Commun. 1995 Oct 24; 215(3):868-73.
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134. Chini EN, Beers KW, Chini CC, Dousa TP. Specific modulation of cyclic ADP-ribose-induced Ca2+ release by polyamines. Am J Physiol. 1995 Oct; 269 (4 Pt 1):C1042-7
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135. Matousovic K, Grande JP, Chini CC, Chini EN, Dousa TP. Inhibitors of cyclic nucleotide phosphodiesterase isozymes type-III and type-IV suppress mitogenesis of rat mesangial cells. J Clin Invest. 1995 Jul; 96 (1):401-10
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136. Beers KW, Chini EN, Dousa TP. All-trans-retinoic acid stimulates synthesis of cyclic ADP-ribose in renal LLC-PK1 cells. J Clin Invest. 1995 May; 95 (5):2385-90
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137. de Toledo FG, Albuquerque MC, Goulart BH, Chini EN. Different thermostabilities of sarcoplasmic reticulum (Ca2+ + Mg2+)-ATPases from rabbit and trout muscles. Comparative Biochemistry & Physiology. Part C Pharmacology, Toxicology, Endocrinology. 1995 May; 111(1):93-8.
     
138. Chini EN, Dousa TP. Enzymatic synthesis and degradation of nicotinate adenine dinucleotide phosphate (NAADP), a Ca(2+)-releasing agonist, in rat tissues. Biochem Biophys Res Commun. 1995 Apr 6; 209(1):167-74.
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139. Beers KW, Chini EN, Lee HC, Dousa TP. Metabolism of cyclic ADP-ribose in opossum kidney renal epithelial cells. Am J Physiol. 1995 Mar; 268 (3 Pt 1):C741-6
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140. Chini EN, Beers KW, Dousa TP. Nicotinate adenine dinucleotide phosphate (NAADP) triggers a specific calcium release system in sea urchin eggs. J Biol Chem. 1995 Feb 17; 270 (7):3216-23
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141. Chini CC, Chini EN, Williams JM, Matousovic K, Dousa TP. Formation of reactive oxygen metabolites in glomeruli is suppressed by inhibition of cAMP phosphodiesterase isozyme type IV. Kidney Int. 1994 Jul; 46 (1):28-36
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142. Chini EN, de Toledo FG, Albuquerque MC, de Meis L. The Ca(2+)-transporting ATPases of rabbit and trout exhibit different pH- and temperature-dependences. Biochem J. 1993 Jul 15; 293 ( Pt 2):469-73.
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143. Chini EN, de Faria FO, Cardoso CM, de Meis L. The enhancement of Ca2+ efflux from sarcoplasmic reticulum vesicles by urea. Arch Biochem Biophys. 1992 Nov 15; 299(1):73-6.
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144. Chini EN, Meyer-Fernandes JR, Sola-Penna M. Monosaccharides and disaccharides decrease the Km for phosphorylation of a membrane-bound enzyme ATPase. Z Naturforsch [C] 1991 Jul-Aug; 46(7-8):644-6.
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145. Chini EN, Montero-Lomeli M, de Meis L. K(+)- and Mg2(+)-dependent hydrolysis of acetyl phosphate catalyzed by the (Ca2+ + Mg2+)-ATPase of sarcoplasmic reticulum. Biochim Biophys Acta. 1990 Nov 30; 1030(1):152-6.
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