Kelli Lytle, Ph.D.

The purpose of this study is to determine the differences in basal and glucse responsiveness blood flow in upperbody subuctaneous adipose tissue of older adults will be compared to younger adults. Blood flow measures will be couple with adipose tissue biopsies to understand alterations in intraceulluar tissue pathways that might regulate blood flow. 

The purpose of this study is to determine the nutrient independent role of adipocyte specific circadian rhythmicity in controlling adipocyte function in humans, to determine the impact of central obesity on adipocyte circadian clock, and to establish for the first-time adipocyte specific direct target genes of the core circadian clock transcription factors, BMAL1 and CLOCK.