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KM3D Multicenter Cancer Consortium: Predicting Patient Response Using 3D Cell Culture Models

Overview

Información sobre este estudio

This study will assess the ability of the Pathos platform to predict which patients will respond to certain colorectal cancer drug treatments. To demonstrate that for patients with advanced colorectal cancer, prediction scores based on in vitro tumor organoid drug response are positively associated with the rate of first line response.    

To demonstrate that for patients with advanced colorectal cancer, prediction scores based on in vitro tumor organoid drug response are positively associated with progression free survival.

To demonstrate that for patients with advanced colorectal cancer who meet the endpoint of first line response, prediction scores based on in vitro tumor organoid drug response are positively associated with duration of first line response.

 

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria:

- A demonstrated primary solid cancer for which it is medically indicated and planned to
be surgically resected, biopsied, or drained (via malignant pleural effusion).

- The ability to ship the tissue sample within 24 hours of removal from the patient.

- Signed and dated consent to giving tissue as well as allowing for de-identified
medical history information regarding administered treatments and treatment outcomes
to be shared.

- over 18 years of age

Exclusion Criteria:

- Presence of a condition(s) or diagnosis, either physical or psychological, or physical
exam finding that precludes participation in the opinion of the Investigator.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 2/9/23. Questions regarding updates should be directed to the study team contact.

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus Contacto

Rochester, Minn.

Investigador principal de Mayo Clinic

David Larson, M.D., M.B.A.

Comunícate con nosotros para obtener el estatus más reciente

Contact information:

Yulia Potter Nichols

(507) 422-9029

PotterNichols.Yulia@mayo.edu

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20566569

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