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Families Genetic Determinants for High Penetrance of Type 1 Diabetes

Overview

Información sobre este estudio

The purpose of this study is to collect genetic material from individuals belonging to families with high prevalence of Type 1 Diabetes and perform whole exome sequencing to identify genetic risk determinants associated with this high prevalence. In addition, antibody panels from enrolled individuals will be reviewed to determine any correlation to identified genetic determinates.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria:

  • Individuals aged 3-80 years with a clinical diagnosis of Diabetes Mellitus, Type I (T1D) with at least one (1) sibling also clinically diagnosed with Diabetes Mellitus, Type I (T1D) (*these individuals to be referred to as “Case Subjects”).
  • Individuals aged > 18 years who are biologically related to a case subject (to include biological siblings, direct line ancestors (parents, grandparents) or descendants (children, grandchildren)).
  • Individuals aged < 18 years of age who are biologically related to a case subject and do not have a diagnosis of T1D (necessary to determine the genetic basis of T1D occurrence in related family members).

Exclusion Criteria: 

  • Individuals aged < 18 years of age who are not biologically related to a case subject and do not have a diagnosis of T1D (pediatric normal donors will not be prospectively recruited).

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 11/10/23. Questions regarding updates should be directed to the study team contact.

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus Contacto

Rochester, Minn.

Investigador principal de Mayo Clinic

Quinn Peterson, Ph.D.

Abierto para la inscripción

Contact information:

CRM Biotrust

MAYOCLINICBIOTRUST@mayo.edu

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20563665

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