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Longitudinal Changes in Islet Function During Pregnancy

Overview

Información sobre este estudio

In this study we will study 120 pregnant women with a BMI >/= 25kg/m2.

The aim is to understand the changes that occur in endocrine pancreatic function during pregnancy. We are recruiting women with an elevated BMI as they will be at higher risk for GDM and following completion of the study we will be able to compare differences in glucose metabolism between those who did and did not develop GDM.

Patients will be identified and contacted by reviewing schedules in the OB clinic and through advertisement. We will only include individuals who have an ultrasound confirmed single pregnancy with no complications and no history of diabetes.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria: 

  • Subjects will be recruited 1 year from their most recent live birth.
  • 30 with GDM in the preceding pregnancy.
  • 30 with no history of GDM.

Exclusion Criteria: 

  •  Individuals < 20 or > 40 years at the preceding pregnancy. 
  • Active systemic illness.
  • Preceding multiple gestation pregnancy.
  • Taking medication that affects glucose metabolism.
  • Upper GI surgery that alters gastric emptying.
  • Current BMI < 25kg/m^2.
  • For the GDM group, those with GDM in any pregnancy prior to the most recent pregnancy will be excluded (to reduce within group heterogeneity)
  • Currently pregnant or breastfeeding.

Eligibility last updated 4/13/23. Questions regarding updates should be directed to the study team contact.

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus Contacto

Rochester, Minn.

Investigador principal de Mayo Clinic

Aoife Egan, M.B., B.Ch., Ph.D.

Abierto para la inscripción

Contact information:

Aoife Egan M.B., B.Ch., Ph.D.

(507) 284-4080

Egan.Aoife@mayo.edu

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20558478

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