Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.
Inclusion Criteria:
Diagnosis of r/r MM with measurable disease by at least one of the following:
- Serum M-protein ≥ 1.0 g/dL
- Urine M-protein ≥ 200 mg/24 hours
- Involved serum free light chain level ≥ 10 mg/dL, with an abnormal kappa-lambda ratio
if the serum M-protein < 1.0 g/dL and/or urine M-protein < 200 mg/24 hours
- Regimens A and A1: MM relapsed or progressed after ≥ 3 prior approved therapies,
including an IMiD, proteosome inhibitor, and anti-CD38 mAb
- Regimens B and B1: MM relapsed or progressed after ≥2 prior approved therapies,
including an IMiD and proteosome inhibitor
Note: for all Regimens, prior BCMA CAR T-cell therapy and BCMA-targeted therapy (e.g.,
bi-specific engagers or antibody-drug conjugates) is allowed.
Exclusion Criteria:
Eastern Cooperative Oncology Group Performance Status (ECOG PS) ≥ 2.
Evidence of insufficient hematologic function:
- ANC <1000/µL without growth factor support ≤7 days prior to measurement.
- Platelet count < 75,000/µL without platelet transfusion ≤ 72 hours prior to measurement.
Evidence of insufficient organ function.
- CrCL <50 ml/min by Cockcroft-Gault or other institutional method.
- T bilirubin > 1.5 x ULN, except for Gilbert's syndrome.
- AST > 3 x ULN or ALT > 3 x ULN, unless directly due to underlying malignancy.
- O2 sat < 92% on room air.
Clinically significant cardiovascular disease:
- Myocardial infarction within 6 months of first treatment
- Unstable angina or CHF of NYHA Grade 2 or higher.
- Cardiac EF < 40%.
Subjects with active central nervous system (CNS) , including leptomeningeal disease.
Subjects with prior CNS involvement may be enrolled into the study if effective treatment
of their CNS disease was completed at least 3 months prior to Day 1 with no evidence of
disease clinically and at least stable findings on relevant CNS imaging.
Non-malignant CNS disease such as stroke, epilepsy, CNS vasculitis, or neurodegenerative
disease or receipt of medications for these conditions in the 2-year period leading up to
study enrollment.
Currently receiving or likely to require immunosuppressive therapy (e.g., prednisone > 5 mg
daily) for any reason during the treatment period, with the exception of corticosteroids.
Clinically significant infections, including:
- HIV positive by serology.
- HBV positive by serology or PCR
- HCV positive by serology or PCR.
Live vaccine <6 weeks prior to start of conditioning.
Receipt of an allograft organ transplant.
Ongoing requirement for systemic graft -versus-host disease therapy.
Plasma cell leukemia defined as a plasma cell count > 2000/mm^3
Prior malignancy (other than current indication including any antecedent hematologic
disorder) within the 2 years prior to enrollment except for the following: basal or
squamous cell carcinomas of the skin, carcinoma in situ of the cervix or breast treated
with curative intent, or localized prostate cancer treated with curative intent, or
malignancy that, in the opinion of the investigator and Sponsor's Medical Monitor, is
considered cured with minimal risk of recurrence within 3 years.
Washout periods from prior therapies:
- For all subjects (Regimens A, A1, B and B1), receipt of the following: Chemotherapy,
or radiation therapy, except for palliative purposes, within 14 days prior to the
first dose of FT576 (Day 1) or five half-lives, whichever is shorter; Investigational
therapy within 30 days prior to the first dose of FT576 study treatment or five
half-lives, whichever is shorter; Biologic therapy (except for anti-CD38 mAbs in
Regimen B and B1), including autologous cellular immunotherapy (e.g. CAR-T/ CAR-NK),
antibody-drug conjugates or bi-specific immune-cell engaging antibody within 30 days
prior to first dose of FT576 (Day 1) or half -lives whichever is shorter. prior
allogenic HSCT or allogenic CAR-T/CAR-NK within 6 months of first dose of FT576
(Day1).
- For subjects in Regimens B and B1 only, receipt of the following: Anti-CD38 therapy
alone or in combination within 3 months prior to the start of daratumumab.
Note: Other protocol defined Inclusion/Exclusion Criteria may apply.
Eligibility last updated 8/24/22. Questions regarding updates should be directed to the study team contact.