Ensayos clínicos

Inclusion Criteria:

- Patients referred for coronary artery cardiac CT imaging or nuclear medicine or MRI
cardiac perfusion within the Department of Radiology or Cardiology.

- Patients who are able and willing to sign the informed consent will be enrolled

- Negative pregnancy test if subject is of child-bearing age (females of child-bearing
potential will be screened for pregnancy using a urine pregnancy test, which will be
administered by the unit study coordinator at no cost to the patient).

Exclusion Criteria:

- Patients unable to provide written informed consent

- Pregnancy

- eGFR ≤ 30

- History of prior moderate or severe contrast reaction includes: unresponsiveness,
severe respiratory distress, convulsions, arrhythmia, cardiopulmonary distress,
progressive angioedema, laryngeal edema, dyspnea, bronchospasm, symptomatic
tachycardia, symptomatic bradycardia, hypotension, hypertensive crisis.

- Any history of required premedication prior to iodinated contrast administration.

- Patients that consent to participation but do not undergo their clinically-indicated,
contrast-enhanced CT, or nuclear medicine or MR perfusion scanning for any reason
(e.g., bad IV, infiltration, reaction, change in indication).

- Patients with coronary artery bypass grafts

- Patients experiencing atrial fibrillation, premature ventricular contractions or other
heart rhythm abnormalities

- Hospitalized patients or patients under care in the Emergency Department

Specific exclusion criteria only for participation in the cardiac stress test arm of this
study (requiring administration of Regadenoson):

- Anything by mouth within three hours of the examination

- Known hypersensitivity to Regadenoson, Adenosine, or Dipyridamole.

- Active ongoing wheezing or poorly controlled asthma or COPD (hospitalized within last
month or receiving treatment for flair within last month).

- Second (type I or II) or third degree atrioventricular (AV) block or sinus node
dysfunction unless patient has functioning artificial pacemaker.

- Ingested greater than 4 oz. of caffeine within the last 12 hours.

- Currently experiencing unstable coronary syndrome.

- Uncontrollable seizures within the last 3 months

Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Eligibility last updated 2/21/23. Questions regarding updates should be directed to the study team contact.