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Head-to-Head Harmonization of Tau Tracers in Alzheimer's Disease (HEAD)

Overview

Información sobre este estudio

The purpose of this study is to compare different ways of measuring tau both in the brain and in the blood over time in healthy controls and individuals with cognitive impairment. We will collect images in healthy elderly people, individuals with mild cognitive impairment and those diagnosed with Alzheimer’s disease to help us learn how the buildup of amyloid and tau proteins may contribute to developing the disease and in normal aging. Healthy young individuals will be used as controls.

This study is composed of 2 timepoints, separated by approximately 18 months. Each timepoint will require visits to the research institution over multiple days.  During these visits, you will receive 3 PET scans, 1 MRI scan, blood draws, and undergo clinical assessments and cognitive testing.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria:

Inclusion Criteria for young healthy subjects:

  • 18-28 (inclusive) years of age.

Inclusion Criteria for cognitively unimpaired (CU) elderly subjects:

  • 50-90 (inclusive) years of age;
  • Have a study partner able to provide an independent evaluation of functioning.

Inclusion Criteria for mild cognitive impairment (MCI) subjects:

  • 50-90 (inclusive) years of age;
  • MCI;
  • Have a study partner able to provide an independent evaluation of functioning.

Inclusion Criteria for ADdementia (AD) subjects:

  • 50-90 (inclusive) years of age;
  • Mild to moderate AD dementia;
  • Have a study partner able to provide an independent evaluation of functioning.

Exclusion Criteria:

  • Inability to complete the PET scans (e.g., claustrophobia, inability to lie still for duration of scans).
  • Pregnancy.
  • Breastfeeding.
  • Inability to complete the MRI scan (e.g., claustrophobia, pacemaker, artificial heart valve, select aneurismal clip, select ear implants,select stents incompatible with 3T MRI, metal fragments or foreign objects in the skin, eyes, or body [dental fillings do not present a risk for MRI]).

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 1/3/24. Questions regarding updates should be directed to the study team contact.

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus Contacto

Rochester, Minn.

Investigador principal de Mayo Clinic

Val Lowe, M.D.

Cerrado; inscripción por invitación

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El estudio no está abierto para todos los que cumplen con los criterios de elegibilidad, sino solamente para las personas que el equipo del estudio ha invitado a participar.

Contact information:

Amber Stephan M.P.A.

(507) 266-2927

Stephan.Amber@mayo.edu

More information

Publicaciones

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Otros temas en investigación

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CLS-20535314

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