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Intrathecal Opioids for Pain Control After Colorectal Resection

Overview

Información sobre este estudio

Pain control is a key for successful postoperative recovery after colorectal (i.e., involving large bowel or rectum) surgery. Spinal analgesia has been shown to be safe and efficacious and commonly used in clinical practice. It involves administering pain medicine through a small needle in the lower portion of a patient's back. The pain medications most commonly used for spinal analgesia are morphine and hydromorphone. Despite their frequent use, the dose which achieves best pain control while reducing unwanted adverse effects has not been determined. We are attempting to determine the optimal dose of spinal morphine and hydromorphone in patients undergoing minimally-invasive (i.e., surgery performed through small entry sites and using cameras) colorectal surgery.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria:

  • Adult patients with an American Society of Anesthesiologists (ASA) physiological status I-III.
  • Undergoing colorectal minimally invasive surgery (MIS).
  • Age between 18 and 75 years of age.
  • Body mass index (BMI) between 18.5 and 40.
  • Ability to understand and read English.

Exclusion Criteria:

  • Not able or unwilling to sign consent.
  • Patients undergoing ileostomy closure.
  • Patients undergoing ambulatory surgery or anticipated to be discharged sooner than 24 hours after surgery
  • Patients with chronic pain, requiring daily opioid use at the time of surgery.
  • Patient intolerant or allergic to opioids, NSAIDs, or acetaminophen.
  • Patients requiring emergent surgery.
  • Any contraindication to neuraxial anesthesia (coagulopathy, localized infection at the site of injection, pre-existing spinal pathology, or peripheral neuropathy).
  • Any patients currently receiving any anticoagulation medication other than aspirin and who have not discontinued the medication per American Society of Regional Anesthesia anticoagulation guidelines22, and/or an abnormal INR.
  • Patients with hepatic or renal insufficiency in as much as the patient is not a candidate for acetaminophen or NSAIDs, respectively.

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus

Rochester, Minn.

Investigador principal de Mayo Clinic

Adam Amundson, M.D.

Cerrado para la inscripción

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20519866

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