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A Study to Evaluate Breathing Muscle Training in Cardiac Rehab

Overview

Información sobre este estudio

We are currently enrolling both healthy volunteers and people who have been diagnosed with heart failure to participate in our research study.  The purpose of this study is to better understand the relationship between exercise, breathing, blood flow and blood pressure.  This study includes two study visits if you are a healthy or heart failure volunteer.    All testing will be performed at our testing center at St. Mary’s Hospital located in Rochester, MN. 

On the first study visit, the research activities will be discussed and all questions will be answered. Once written consent is provided and the participant is enrolled, lung function and exercise capacity will be measured.

The second study visit includes two separate breathing muscle workouts (a light and moderate workload) each followed by 10 min of light to moderate cycling exercise. In addition, two breathing tests will also be performed. During this visit, blood is drawn during exercise.

If you are a patient at Mayo Clinic, who is currently enrolled or will be enrolling in a cardiac rehabilitation exercise program, you will have the option to complete four study visits.  Your first two study visits as described above will be completed at the beginning of cardiac rehabilitation and then we will ask you to return to complete those same two study visits following the completion of your cardiac rehabilitation program.

Remuneration and parking reimbursement are provided.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria - Heart Failure Group:

  • Patients ≥ 18 years.
  • No history of dangerous arrhythmias.
  • Not pacemaker dependent.
  • Having a body mass index ≤ 40kg/m^2.
  • Currently non-smokers with < 15 pack year history.
  • Able to exercise (i.e., without significant orthopedic limitations or musculoskeletal disorders limiting their ability to exercise). 

Inclusion Criteria - Healthy Control Group:

  • Adults ≥ 18 years of age.
  • Absent a history of HFpEF or HFrEF, pulmonary, neurologic, orthopedic, or other diseases affecting the neuromuscular system.
  • Controls will be matched for age and sex.

Additional inclusion criteria include:

  • BMI ≤ 40kg/m^2.
  • current non-smokers with smoking history < 15 pack years.
  • Able to engage in exercise (i.e., without significant orthopedic limitations or musculoskeletal disorders limiting their ability to exercise).

Exclusion Criteria:

  • History of dangerous arrhythmias.
  • Body mass index > 40 kg/m^2.
  • Current smokers and/or smoking history > 15 pack years.
  • Pregnant women (testing will be done by research team if requested).
  • Uremia, history of allergy to iodides.
  • Impaired renal function.
  • Peripheral artery disease.
  • Creatinine value greater than or equal to 1.3 mg/dL (via clinical record within the past 6 months).
  • Diagnosis of liver disease.
  • Individuals who are not able to engage in exercise.
  • Asthmatic patients with a low symptom perception and suffer frequency, severe exacerbations or with an abnormally low perception of dyspnea.
  • Ruptured eardrum or any other condition of the ear.

Eligibility last updated 10/7/21. Questions regarding updates should be directed to the study team contact.

 

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus Contacto

Rochester, Minn.

Investigador principal de Mayo Clinic

Joshua Smith, Ph.D., M.S.

Abierto para la inscripción

Contact information:

Joshua Smith Ph.D., M.S.

(507) 266-2690

bruhn.eric@mayo.edu

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20516797

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