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A Study to Analyze Fractures and Bone Disease in Living Kidney Donors

Overview

Información sobre este estudio

The purpose of this study is to to determine whether or not prior living kidney donors have an increased risk of bone fractures. The study will also determine bone structure and health in prior living donors as compared to matched controls.  

 

 

 

 

We will determine if living kidney donors are at increased risk of bone disease and fractures following kidney donation. This information will be valuable in informing future kidney donors of the risks of donation and in devising treatments, such as administration of vitamin D analogs like calcitriol, to prevent such complications.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria:

Aim 1: Survey (Donors)

  • Donated a kidney at one of the three participating sites.
  • 10 or more years have passed since donation.
  • Age ≥ 50 at time of study enrollment.

Aim 1: Survey (Controls)

  • Subjects in the REP population.
  • Medical records available for the five years preceding age at matching (age at donation).  
  • Matching will be based on: age, year of donation, sex, race/ethnicity, body mass index, comorbidity and selected risk factors (smoking, education level) status at year of donation.

Aim 2: Skeletal health assessment (Donors and Controls

  • Subjects who have completed the survey
  • Willing to come in for the in-person assessment

Exclusion Criteria:

Aim 1: Survey (Donors)

  • Deceased.
  • Not willing to return the survey.

Aim 1: Survey (Controls)

  • Deceased.
  • Not willing to return the survey.
  • History of the following conditions:
    • Diabetes mellitus, liver disease, kidney disease, nephrolithiasis, malabsorption syndrome, past history of non-traumatic fractures.

Aim 2: Skeletal health assessment (Donors and Controls)

  • Subjects who did not participate in the survey.
  • Subjects not willing to come for the in-person evaluation.
  • Women of childbearing potential. 

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus Contacto

Rochester, Minn.

Investigador principal de Mayo Clinic

Rajiv Kumar, M.D.

Cerrado para la inscripción

Contact information:

Adam Miller

(507) 266-8147

Miller.Adam@mayo.edu

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20513566

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