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A Study to Evaluate the Surgical Removal of Residual Brain Tumors Prior to Recurrence

Overview

Información sobre este estudio

The purpose of this study is to evaluate the safety and feasibility of surgical resection for pre-recurrent brain tumors. Eligible patients with surgically accessible latent tumors desiring surgical resection will be enrolled to prospectively track short- and long-term outcomes. Safety will be evaluated by quantifying rates of surgical morbidity as compared to patients undergoing RT after surgery, or no surgery for similar latent disease. Variables evaluated will include postoperative complications including death within 30 days, wound infection, length of hospital stay, and readmission rates.

 

 

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria:

  • Age ≥ 18 years.
  • Histological or cytological confirmation of brain tumor and/or suspected brain tumor based on clinical and radiologic findings.
  • Prior chemotherapy and/or radiation treatment directed to the known/suspected tumor.
  • Radiographic evidence of residual or previously unresected tumor.
  • Willingness to undergo surgery and sign informed consent.
  • Patients not currently eligible for an alternate competing interventional clinical trial.
  • Enrollment in the Mayo Clinic Cancer Center Neuro-Oncology Program Registry for the study of Nervous System Tumors (IRB#12-003458)

Exclusion Criteria:

  • Age < 18 years.
  • Prior gross total resection of brain tumor leading to absence of visible latent disease (exemption available for post-operative enrollment).
  • Any contraindication to surgery, including anyone who in the opinion of the surgeon is at unreasonably elevated risk of wound complications.
  • Avastin within the past 6 months for any reason.
  • Patients who have not yet undergone surgery or radiation, but who would be appropriate candidates for an alternate interventional clinical trial (e.g., post-operative fractionated vs. single fraction radiation to the surgical cavity for surgical brain mets).

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus Contacto

Rochester, Minn.

Investigador principal de Mayo Clinic

Terence Burns, M.D., Ph.D.

Abierto para la inscripción

Contact information:

RST Neurologic Surgery Research Team

(507) 293-1963

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20509903

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