Ensayos clínicos

Inclusion Criteria - COVID-19 Cohort:

• Patient age: 60-85 years old.
• SARS-CoV-2 infection confirmed by PCR.
• Need for hospitalization due to COVID-19 pneumonia.
• Need for ≥ 2L supplemental oxygen at any point during hospitalization.

Inclusion Criteria - CONTROL Cohort:

• Patient age: 60-85 years old.
• No pre-existing history of interstitial lung disease or chronic lung disease, except for mild COPD with FEV1 > 80% predicted and FEV1/FVC < 0.7.
• Absence of lung infiltrate, fever or any signs or infection.
• Undergoing bronchoscopy for evaluation of lung nodule or adenopathy.

Exclusion Criteria - COVID-19 and CONTROL Cohorts:

• Unable to provide consent to participate in the study.
• Patient under guardianship or curatorship.
• Pre-existing interstitial lung disease, pulmonary fibrosis or chronic lung disease, except for mild COPD as outlined in “inclusion criteria.”
• Active cigarette smoking, vaping or other inhalation use (former smoker providing quit > 90 days prior to admission acceptable).
• > 20 pack years.
• Immunocompromised host status due to ongoing therapy with methotrexate, cellcept, azathioprine, prednisone dose > 15 mg daily, rituximab, cyclophosphamide or other biologic agents.
• Chemotherapy or Radiation therapy in last 2 years.