Ensayos clínicos

Inclusion Criteria:

• Adult patients, men and women ages 18-75.
• Symptoms of dyspepsia thought to represent FD.
• Meeting Rome IV criteria.
• Patients will be identified as direct referrals to the general GI clinic or the motility clinic. 
  Referring providers will be notified of active research in the Division of Gastroenterology, and this study will be highlighted. 
• Symptoms will be assessed and patients will be categorized into either the postprandial distress syndrome (PDS), epigastric pain syndrome (EPS), or mixed subtype, using Rome IV criteria.

Exclusion Criteria: 

• Patients will be excluded from the study if symptoms are thought to represent an organic disorder (e.g., peptic ulcer disease, hepatitis, pancreatitis, inflammatory bowel disease, type I diabetes, a known malignancy, radiation-induced injury, an active infection, vasculitis, celiac disease).
• Patients have known uncontrolled GERD, esophagitis, eosinophilic esophagitis or H. pylori.
• Patients with prior surgery to the esophagus, stomach or duodenum will be excluded. 
• Patients taking opioids will also be excluded.  
• Alcohol and tobacco use will be assessed.
• Presence of psychiatric conditions, such as anxiety, depression, post-traumatic stress disorder, bipolar disorders, and eating disorders, such as anorexia nervosa and bulimia. 
• No patients will be excluded based on reported substance use or presence of a psychiatric comorbidity.  
• Patients with co-existing IBS will be allowed to enter the study as long as IBS symptoms are not predominant.