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An Integrated Metagenomics and Immunoproteomics Study of the Role of Microbiome in Pouchitis Development

Overview

Información sobre este estudio

The primary purpose of this study is to establish an Arizona-based patient recruitment and sample collection infrastructure with a wide network of gastroenterologists in Maricopa County, including both academic and community gastroenterologists.  Secondarily, they will analyze the pouch microbiota and anti-microbial antibodies in longitudinal samples collected from patients undergoing RPC with IPAA.  We will compare data from patients who develop pouchitis and those who do not develop pouchitis to eventually identify antibody markers that can prognosticate pouchitis and understand the role of bacteria or immune response to them in pouchitis development. 

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria:

  • Age greater than or equal to 18 years.
  • Confirmed diagnosis of ulcerative colitis and/or dysplasia.
  • Subjects who are undergoing or have undergone a proctocolectomy with ileal pouch anal anastomosis and are scheduled for, or have had takedown of ileostomy at any time.
  • The patient is willing and able to sign the written, informed consent document.

Exclusion Criteria:

  • Female patients who are pregnant.
  • Patients that are unable to adhere to the protocol guidelines and/or schedule.
  • Patients unable to give informed consent.

Eligibility last updated 9/22/21. Questions regarding updates should be directed to the study team contact.

 

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus Contacto

Scottsdale/Phoenix, Ariz.

Investigador principal de Mayo Clinic

Jonathan Leighton, M.D.

Cerrado para la inscripción

Contact information:

Brooke Brown

(480) 301-4735

Brown.Brooke@mayo.edu

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20502613

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