Ensayos clínicos

Inclusion Criteria:

• Adults, 20 - 45 years old, inclusive.
• Body mass index (BMI) of > 24 kg/m^2.
• Fasting serum glucose < 126 mg/dl.

Exclusion Criteria:

• BMI ≤ 24 kg/m^2.
• Fasting serum glucose ≥ 126 mg/dl.
• Currently taking calcium and/or vitamin D supplements and unwilling to stop for study duration.
• Serum total calcium > 10.2 mg/dL.
• Serum inorganic phosphorus > 4.5 mg/dL.
• Pregnancy or breastfeeding.
• Diagnosis of Diabetes Mellitus.
• Diagnosis of Rheumatoid Arthritis.
• Diagnosis of Chronic Obstructive Pulmonary Disease (COPD).
• Renal insufficiency/failure (serum creatinine >1.5 mg/dl men; >1.3 mg/dl women).
• Chronic active liver disease (bilirubin > 1.2 mg/dL, AST > 144 IU/L, or ALT > 165 IU/L).
• History of chronic hepatitis.
• History of depression, anxiety or psychiatric disease.
• Active coronary artery disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment).
• Oral warfarin or history of blood clotting disorders.
• Platelet count < 100,000 per uL within the last 7 days.
• Alcohol consumption greater than 2 glasses/day or other substance abuse.
• Untreated or uncontrolled thyroid disorders (outside a TSH range of 0.5 to 10 mIU/L).
• Debilitating chronic disease (at the discretion of the investigators).
• The presence of infections, highly communicable diseases (AIDS, active tuberculosis, venereal disease, hepatitis).
• Any malignancy.