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A Study of Study of Immune Tolerance Mechanisms in Kidney Transplant Patients

Overview

Información sobre este estudio

Hypothesis: we hypothesize that the abundance and functions of Breg subsets in kidney transplant patients could be associated with transplant tolerance and rejection, including DSA-mediated kidney transplant rejection. In addition, oral corticosteroid treatment significantly alters the frequency and function of Breg subsets, which could lead altered clinical outcomes.

Aims, purpose, or objectives:
1. Investigate the frequency Bregs and their ability to express IL-10 along with other immune cells in the context of tolerance/rejection in kidney transplant patients.
we hypothesize that the abundance and functions of Breg subsets in kidney transplant patients could be associated with transplant tolerance and rejection, including DSA-mediated kidney transplant rejection.

2.Investigate the frequency and functions of Bregs along with other immune cells in the setting of long term corticosteroid use.
We hypothesize that oral corticosteroid treatment significantly alters the frequency and function of Breg subsets, which could lead altered clinical outcomes.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria:

  • Subjects 18 – 64 years of age.
  • Subjects who weigh at least 110 pounds (50 kilograms).
  • Subjects who understand that participation is voluntary.
  • Subjects who are able to complete the informed consent process.

Exclusion Criteria: 

  • Subjects who are younger than 18 years of age.
  • Subjects who have a current acute viral, bacterial, or fungal infection.
  • Subjects diagnosed with the Human Immunodeficiency Virus (HIV), or who have tested positive for HIV documented by any licensed ELISA assay and confirmed by Western Blot procedures at any time prior to donation.
  • Pregnant women.
  • Simultaneous dual organ transplant.
  • ABO incompatible transplants.
  • Patients with evidence of recurrentprimary disease.
  • Ongoing BK nephropathy.

 

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus Contacto

Scottsdale/Phoenix, Ariz.

Investigador principal de Mayo Clinic

SangKon Oh, Ph.D.

Abierto para la inscripción

Contact information:

April Howard R.N.

(480) 342-5756

Howard.April@mayo.edu

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20482090

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