Ensayos clínicos

Inclusion Criteria:

• Has esophageal or gastroesophageal cancer and expected to receive systemic anticancer therapy.
• Dysphagia score of 1, 2, 3 or 4.
• Age ≥ 18 years old.
• ASA ≤ 4.
• Deemed not a candidate for esophageal cancer surgical resection.
• Female subjects must be either post-menopausal, surgically sterilized, or willing to use an acceptable method of birth control (i.e., total abstinence, birth control pills, an IUD, diaphragm, progesterone injections or implants, or condoms plus a spermicide) for the duration of the study.

Exclusion Criteria:

• ECOG performance status greater than 2.
• Patient who received radiation treatment in the prior 8 weeks.
• Known brain metastases causing cranial nerve deficits which can cause dysphagia.
• Inability to undergo an EGD.
• Pregnant or nursing.
• Surgery or anatomy where capacity of stomach is reduced making cryotherapy contraindicated.
• Patients with tracheoesophageal fistula.
• Expected survival less than 3 months.