Ensayos clínicos

Overview

Información sobre este estudio

This project is focused on understanding the risk of cognitive impairment and dementia in total hip and total knee arthroplasty patients. It involves 4 aims:

AIM 1. To determine the risk of dementia in patients with TJA. Using the REP, we will identify a population-based cohort of 9,000 TJA patients and a matched cohort of 9,000 non-TJA patients. The overall risk of dementia and subtypes will be compared between the two cohorts.

AIM 2. To determine cognitive function and neuroimaging measures in patients with TJA. Within the existing data from the MCSA cohort (IRB: 14-004401), we will identify the sub-cohort of 1,200 patients with TJA and compare their cross-sectional and longitudinal cognition and neuroimaging measures with a matched cohort of non-TJA subjects.

AIM 3. To determine the association between serum and synovial fluid metal ion levels with cognitive function and neuroimaging findings. We will prospectively recruit 100 TJA patients presenting for revision TJA and with at least 10 years of exposure to TJA implants. Serum metal ion levels will be measured and TJA patients will undergo cognitive assessments and neuroimaging, similar to the MCSA cohort.

AIM 4. To determine neuropathological features and metal ion levels in postmortem brain autopsy tissue of patients with TJA. We will use stored brain autopsy tissues of 100 patients with TJA and 100 non-TJA subjects.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Sedes participantes de Mayo Clinic

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