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Digital Biomarkers for Objectively and Remotely Monitoring Migraine

Overview

Información sobre este estudio

Changes in vision are commonly reported by patients during migraine attacks. Even in patients that do not report changes in vision, we have noted objective changes as demonstrated by changes in the King-Devick Test (KDT), a quantitative measure of rapid eye movement; which was 6.5 seconds slower (SD 7.6 seconds, p<0.001) during a migraine attack compared to between migraine attacks. This study aims to evaluate changes in timed rapid number naming using the KDT during the twelve hours prior to a migraine attack (“pre-attack” phase) and during the migraine attack compared to the between attack phase. Accurate prediction of an impending migraine attack based on changes in the KDT would allow for future studies that determine the effectiveness of proactively treating migraine attacks during the very early “pre-symptomatic” stage, a strategy that would likely provide superior outcomes compared to current standard-of-care.

Elegibilidad para la participación

Los requisitos de elegibilidad de los participantes incluyen la edad, el sexo, el tipo y el estadio de la enfermedad, y los problemas de salud o tratamientos previos. Las pautas difieren de un estudio a otro e identifican quiénes pueden o no pueden participar. No hay garantía de que cada persona elegible que desee participar en un ensayo se inscribirá. Comunícate con el equipo del estudio para analizar la elegibilidad del estudio y la posible participación.

Inclusion Criteria:

  1. 18 years of age or older
  2. Migraine with or without aura diagnosed according to ICHD3 diagnostic criteria
  3. 4-10 migraine attacks per month (average over the prior 3 months)
  4. Fewer than 15 headache days per month (average over the prior 3 months)
  5. Willing to provide KDT samples 3 times per day
  6. Willing to maintain a daily headache diary

 

Exclusion Criteria:

  1. Greater than 10 migraine attacks per month (average over the prior 3 months)
  2. 15 or greater headache days per month (average over the prior 3 months)
  3. Baseline ocular conditions
  4. Other neurologic diseases or history of intracranial surgery
  5. History of concussion within past 2 years

Sedes participantes de Mayo Clinic

Los estatus de los estudios cambian con frecuencia. Comunícate con el equipo del estudio para obtener la información más actualizada acerca de la posibilidad de participar.

Sede de Mayo Clinic Estatus Contacto

Scottsdale/Phoenix, Ariz.

Investigador principal de Mayo Clinic

Juliana VanderPluym, M.D.

Cerrado para la inscripción

Contact information:

Juliana VanderPluym M.D.

(480)301-9443

VanderPluym.Juliana@mayo.edu

More information

Publicaciones

Publications are currently not available

Otros temas en investigación

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CLS-20445070

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